Abstract
Introduction. The nine components1 that comprise the classical pathway constitute a family of proteins whose functions can be divided into three phases: recognition, activation, and attack. Most early work in the field focused on defining the functional activities of the various components, leading to our present concept of their reaction sequence. More recently, as modern biochemical techniques have been used to study these proteins, the physicochemical basis for their activities has begun to be elucidated.
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References
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Berger, M. et al. (1988). Complement and Complement Reactions. In: Rother, K., Till, G.O. (eds) The Complement System. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97038-2_2
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