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Primary Malignant Melanoma of the Uvea: Radioactive Plaque Therapy and Other Treatment Modalities

  • Chapter
Radiotherapy of Intraocular and Orbital Tumors

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Primary tumors of the eye are rare but important malignant lesions. In the United States, they represent less than 0.2% of all cancers (American Cancer Society 1990). Primary malignant melanoma of the uvea (MMU) is the most common primary tumor of the eye in adults. It constitutes 80% of primary eye tumors and about 6% of cutaneous melanomas (American Cancer Society 1990; Chalkely 1980). This tumor is seen in older patients, with nearly equal frequency in males and females. MMU has been reported to be from 8 to 20 times more common among American whites than among blacks (Callender et al. 1942; Campbell Wilder and Paul 1951; Chalkely 1980).

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References

  • Affeldt JC, Minckler DS, Azen SP et al. (1980) Prognosis in uveal melanoma with extrascleral extension. Arch Ophthalmol 98:1975–1979

    Article  PubMed  CAS  Google Scholar 

  • American Cancer Society (1990) Cancer Statistics 1990. CA 4:9–26

    Google Scholar 

  • American Joint Committee on Cancer (1988) Melanoma of the uvea. In: Behrs OH (ed) Manual for staging of cancer. JB Lippincott, Philadelphia, pp231–233

    Google Scholar 

  • Astrahan MA, Liggett PE, Luxton G et al. (1987) A 500 kHz localized current field hyperthermia system for use with ophthalmic plaque radiotherapy. Int J Hyperthermia 3:423–432

    Article  PubMed  CAS  Google Scholar 

  • Astrahan MA, Luxton G, Jozsef G et al. (1990a) An interactive treatment planning system for ophthalmic plaque brachytherapy. Int J Radiat Oncol Biol Phys 18:679–687

    Article  PubMed  CAS  Google Scholar 

  • Astrahan MA, Luxton G, Jozsef G et al. (1990b) Optimization of I-125 ophthalmic plaque brachytherapy. Med Phys 17:1053–1057

    Article  PubMed  CAS  Google Scholar 

  • Augsburger JJ, Gamel JW, Sardi VF et al. (1986) Enucleation vs. cobalt plaque radiotherapy for malignant melanomas of the choroid and ciliary body. Arch Ophthalmol 104:655–661

    Article  PubMed  CAS  Google Scholar 

  • Austin-Seymour M, Munzenrider JE, Goitein M et al. (1985) Progress in Low-LET heavy particle therapy: intracranial and paracranial tumors and uveal melanomas. Radiat Res 104:S219–S226

    Article  Google Scholar 

  • Beddoe AH (1975) Isoexposure curves for Co-60 ophthalmic applicators. Aust Radiol 19:145–151

    Article  CAS  Google Scholar 

  • Boniuk M, Girard LJ (1965) Malignant melanoma of the choroid treated with photocoagulation, trans-scleral diathermy and implanted radon seeds. Am J Ophthalmol 59:212–216

    PubMed  CAS  Google Scholar 

  • Brady LW, Shields JA, Augsburger JJ et al. (1982) Malignant intraocular tumors. Cancer 49:578–585

    Article  PubMed  CAS  Google Scholar 

  • Brady LW, Markoe AM, Amendola BE et al. (1988) The treatment of primary intraocular malignancy. Int J Radiat Oncol Biol Phys 15:1355–1361

    Article  PubMed  CAS  Google Scholar 

  • Brady LW, Shields J, Augsburger J et al. (1989) Complications from radiation therapy to the eye. Front Radiat Ther Oncol 23:238–250

    PubMed  CAS  Google Scholar 

  • Burns RP, Fraunfelderr FT, Klass AM (1962) A laboratory evaluation of nucleation in the treatment of intraocular malignant melanoma. Arch Ophthalmol 67:490–500

    Article  PubMed  CAS  Google Scholar 

  • Callender GR, Wilder HC, Ash JE (1942) Five hundred melanomas of the choroid and ciliary body followed five years or longer. Am J Ophthalmol 25:962–967

    Google Scholar 

  • Campbell Wilder H, Paul EV (1951) Malignant melanoma of the choroid and ciliary body: a study of 2535 cases. Milit Surg 109:370–378

    Google Scholar 

  • Cappin JM (1973) Radiation scleral necrosis simulating early scleromalacia perforans. Br J Ophthalmol 57:425–428

    Article  PubMed  CAS  Google Scholar 

  • Casebow MP (1971) The calculation and measurement of exposure distributions from Co-60 ophthalmic applicators. Br J Radiol 44:618–624

    Article  PubMed  CAS  Google Scholar 

  • Chalkely T (1980) Ocular Melanoma Task Force report. Am J Ophthalmol 90:728–733

    Google Scholar 

  • Chan B, Rotman M, Randall GJ (1972) Computerized dosimetry of Co-60 ophthalmic applicators. Radiology 103:705–707

    PubMed  CAS  Google Scholar 

  • Chan RC, Shukovsky LJ (1976) Effects of irradiation on the eye. Radiology 120:673–675

    PubMed  CAS  Google Scholar 

  • Char DH (1978) Metastatic choroid melanoma. Am J Ophthalmol 86:76–80

    PubMed  CAS  Google Scholar 

  • Char DH, Castro JR (1982) Helium ion therapy for choroidal melanoma. Arch Ophthalmol 100:935–938

    Article  PubMed  CAS  Google Scholar 

  • Char DH, Castro JR, Quivey JM et al. (1980) Helium ion charged particle therapy for choroidal melanoma. Ophthalmology 87:565–570

    PubMed  CAS  Google Scholar 

  • Char DH, Phillips TL, Andejewski Y et al. (1988) Failure of pre-enucleation radiation to decrease uveal melanoma mortality. Am J Ophthalmol 106:21–26

    Article  PubMed  CAS  Google Scholar 

  • Char DH, Castro JR, Quivey JM et al. (1989) Uveal melanoma radiation I-125 brachytherapy versus helium ion irradiation. Ophthalmology 96:1708–1715

    PubMed  CAS  Google Scholar 

  • Chenery SAG, Galbraith DM, Leung PMK (1977) Application of small Co-60 beams in the treatment of malignant melanoma at the optic disc. Int J Radiat Oncol Biol Phys 2:1021–1026

    Article  PubMed  CAS  Google Scholar 

  • Chenery SAG, Japp N, Fitzpatrick PJ (1983) Dosimetry of radioactive gold grains for the treatment of choroidal melanoma. Br J Radiol 56:415–420

    Article  PubMed  CAS  Google Scholar 

  • Chiu-Tsao ST, Anderson LL, O’Brien K et al. (1990) Dose determination for I-125 seeds. Med Phys 17:815–825

    Article  PubMed  CAS  Google Scholar 

  • Cogan DG, Donaldson DD, Reese AB (1952) Clinical and pathological characteristics of radiation cataract. Arch Ophthalmol 47:55–70

    Article  CAS  Google Scholar 

  • Collaborative Ocular Melanoma Study Group (1990) Accuracy of diagnosis of choroidal melanomas in the Collaborative Ocular Melanoma Study. COMS Report No. 1. Arch Ophthalmol 108:1268–1273

    Article  Google Scholar 

  • Coleman KJ, Lizzi FL, Burgess SEP et al. (1986) Ultrasonic hyperthermia and radiation in the management of intraocular malignant melanoma. Am J Ophthalmol 101:635–642

    PubMed  CAS  Google Scholar 

  • Cruess AF, Augsberger JJ, Shields JA et al. (1984) Regression of posterior uveal melanomas following cobalt-60 plaque radiotherapy. Ophthalmology 91:1716–1719

    PubMed  CAS  Google Scholar 

  • Davidorf FH, Pajka JT, Makley TA et al. (1987) Radiotherapy for choroidal melanoma. An 18 year experience with radon. Arch Ophthalmol 105:352–355

    Article  PubMed  CAS  Google Scholar 

  • Donoso LA, Augsburger JJ, Shields JA et al. (1986) Metastatic uveal melanoma. Correlation between survival time and cytomorphometry of primary tumors. Arch Ophthalmol 104:76–78

    Article  PubMed  CAS  Google Scholar 

  • Earle J, Kline RW, Robertson DM (1987) Selection of iodine-125 for the Collaborative Ocular Melanoma Study. Arch Ophthalmol 105:763–764

    Article  PubMed  CAS  Google Scholar 

  • Einhorn LH, Burgess MA, Gottlieb JA (1974a) Metastatic patterns of choroidal melanoma. Cancer 34:1001–1004

    Article  PubMed  CAS  Google Scholar 

  • Einhorn LH, Burgess MA, Vallejos C et al. (1974b) Advanced metastatic melanoma — prognostic correlations and response to treatment in 26 patients. Cancer Res 34:1994–2004

    Google Scholar 

  • Ferry AP (1964) Lesions mistaken for malignant melanoma of the posterior uvea. Arch Ophthalmol 72:463–469

    Article  PubMed  CAS  Google Scholar 

  • Finger PT, Packer S, Svitra PP et al. (1985) Thermoradiotherapy for intraocular tumors. Arch Ophthalmol 103:1574–1620

    Article  PubMed  CAS  Google Scholar 

  • Finger PT, Packer S, Paglione RW et al. (1989) Thermoradiotherapy of choroidal melanoma. Clinical experience. Ophthalmology 96:1384–1388

    PubMed  CAS  Google Scholar 

  • Finger PT, Moshfeghi DM, Ho TK (1991) Palladium-103 ophthalmic plaque radiotherapy. Arch Ophthalmol 109:1610–1613

    Article  PubMed  CAS  Google Scholar 

  • Fitterman HN, McLean JA (1963) Malignant melanoma: a fifteen year review. Am J Ophthalmol 56:90–97

    Google Scholar 

  • Flocks M, Gerende JH, Zimmerman LE (1955) The size and shape of malignant melanomas of the choroid and ciliary body in relation to prognosis and histologic characteristics. A statistical study of 210 tumors, trans Am Acad Ophthalmol 55:740–758

    Google Scholar 

  • Fraunfelder FT, Boozman FW, Wilson RS et al. (1977) No-touch technique for intraocular malignant melanomas. Arch Ophthalmol 95:1616–1620

    Article  PubMed  CAS  Google Scholar 

  • Gomer CJ, Doiran DR, Jester JV et al. (1983) Hematoporphyrin derivative photoradiation therapy for the treatment of intraocular tumors: examination of acute normal ocular toxicity. Cancer Res 43:721–727

    PubMed  CAS  Google Scholar 

  • Gomer CJ, Hayashi N, Liu G et al. (1987) Yag laser induced hyperthermia as an adjunctive treatment for ocular melanoma (abstr). Invest Ophthalmol Vis Sci 28:117

    Google Scholar 

  • Gomori JM, Grossman RI, Shields JA et al. (1986) Choroidal melanomas: correlation of NMR spectroscopy and MR imaging. Radiology 158:443–445

    PubMed  CAS  Google Scholar 

  • Gragoudas ES, Goitein M, Verhey L et al. (1980) Proton beam irradiation: an alternative to enucleation for intraocular melanomas. Ophthalmology 87:571–581

    PubMed  CAS  Google Scholar 

  • Gragoudas ES, Goitein M, Verhey L et al. (1982) Proton beam irradiation of nveal melanomas: results of a 51/2 year study. Arch Ophthalmol 100:928–934

    Article  PubMed  CAS  Google Scholar 

  • Ham WT (1953) Radiation cataract. Arch Ophthalmol 50:618–643

    Article  Google Scholar 

  • Jensen OA (1982) Malignant melanomas of the human uvea in Denmark 1943–1952. Acta Ophthalmol 60:161–182

    CAS  Google Scholar 

  • Karlsson UL, Augsburger JJ, Shields JA et al. (1989) Recurrence of posterior uveal melanoma after Co-60 episcleral plaque therapy. Ophthalmology 96:382–388

    PubMed  CAS  Google Scholar 

  • Karolis C, Frost RB, Billson FA (1990) A thin I-125 eye plaque to treat intraocular tumors using an acrylic insert to precisely position the sources. Int J Radiat Oncol Biol Phys 18:1209–1213

    Article  PubMed  CAS  Google Scholar 

  • Krishnaswamy V (1978) Dose distribution around an I-125 seed source in tissue. Radiology 126:489–491

    PubMed  CAS  Google Scholar 

  • Lagendijk JJW (1982) A microwave heating technique for the hyperthermic treatment of tumors of the eye, especially retinoblastoma. Phys Med Biol 27:1313–1324

    Article  PubMed  CAS  Google Scholar 

  • Lean EK, Cohen D, Liggett PE et al. (1990) Episcleral radioactive plaque therapy: initial clinical experience with 56 patients. Am J Clin Oncol 13:185–190

    Article  PubMed  CAS  Google Scholar 

  • Lederman M (1956) Radiotherapy in the treatment of orbital tumors. Br Ophthalmol 40:592–610

    Article  CAS  Google Scholar 

  • Liggett PE, Pince KJ, Astrahan MA et al. (1990) Localized current field hyperthermia: effects on normal ocular tissue. Int J Hyperthermia 6:517–527

    Article  PubMed  CAS  Google Scholar 

  • Lincoff H, McLean J, Long R (1967) The cryosurgical treatment of intraocular tumors. Am J Ophthalmol 63:389–398

    PubMed  CAS  Google Scholar 

  • Ling CC, Yorke ED, Spiro IJ et al. (1983) Physical dosimetry of I-125 seeds of a new design for interstitial implant. Int J Radiat Oncol Biol Phys 9:1747–1752

    PubMed  CAS  Google Scholar 

  • Ling CC, Schell MC, Yorke ED et al. (1985) Two-dimensional dose distribution of I-125 seeds. Med Phys 12:652–655

    Article  PubMed  CAS  Google Scholar 

  • Ling CC, Chen GTY, Boothby JW et al. (1989) Computer assisted treatment planning for I-125 ophthalmic plaque radiotherapy. Int J Radiat Oncol Biol Phys 17:405–410

    Article  PubMed  CAS  Google Scholar 

  • Lommatzsch PK (1983) ß-Irradiation of choroidal melanoma with 106Ru/106Rh applicators: 16 years experience. Arch Ophthalmol 101:713–717

    Article  PubMed  CAS  Google Scholar 

  • Lommatzsch PK (1986) Results after ß-irradiation (106Ru/ 106Rh) of choroidal melanomas: 20 years experience. Br J Ophthalmol 70:844–851

    Article  PubMed  CAS  Google Scholar 

  • Luxton G, Astrahan MA, Liggett PE et al. (1988a) Dosimetric calculations and measurements of gold plaque ophthalmic irradiators using iridium-192 and iodine-125 seeds. Int J Radiat Oncol Biol Phys 15:167–176

    Article  PubMed  CAS  Google Scholar 

  • Luxton G, Astrahan MA, Petrovich Z (1988b) Measurements of backscatter from a single seed of I-125 for ophthalmic plaque dosimetry. Med Phys 15:397–400

    Article  PubMed  CAS  Google Scholar 

  • Luxton G, Astrahan MA, Findley DO et al. (1990) Measurement of dose rate from exposure — calibrated I-125 seeds. Int J Radiat Oncol Biol Phys 18:1199–1207

    Article  PubMed  CAS  Google Scholar 

  • MacFaul PA, Bedford MA (1970) Ocular complications after therapeutic irradiation. Br J Ophthalmol 54:237–247

    Article  PubMed  CAS  Google Scholar 

  • MacFaul PA, Morgan GL (1977) Histological changes in malignant melanomas of the choroid after cobalt plaque therapy. Br J Ophthalmol 61:221–228

    Article  PubMed  CAS  Google Scholar 

  • Magnus L (1967) Tiefendosisberechnung für die Co-60 Augenapplikatoren CKA 1–4 (nach Stallard). Strahlentherapie 132:379–386

    PubMed  CAS  Google Scholar 

  • Markoe AM, Brady LW, Shields JA et al. (1985) Malignant melanoma of the eye: treatment of posterior uveal lesions by Co-60 plaque, radiotherapy versus enucleation. Radiology 156:801–803

    PubMed  CAS  Google Scholar 

  • McLean IW, Foster WD, Zimmerman LE (1977) Prognostic factors in small malignant melanomas of the choroid and ciliary body. Arch Ophthalmol 95:48–58

    Article  PubMed  CAS  Google Scholar 

  • McLean IW, Foster WD, Zimmerman LE et al. (1983) Modifications of Callender’s classification of uveal melanoma at the Armed Forces Institute of Pathology. Am J Ophthalmol 96:502–509

    PubMed  CAS  Google Scholar 

  • Merriam GR, Focht E (1957) A clinical study of radiation cataracts and their relationship to dose. Am J Roentgenol Radiat Ther 77:759–785

    Google Scholar 

  • Nakissa N, Rubin P, Strohl R et al. (1983) Ocular and orbital complications following radiation therapy of paranasal sinus malignancies and review of literature. Cancer 51:980–986

    Article  PubMed  CAS  Google Scholar 

  • Naquin HA (1954) Exenteration of the orbit. Arch Ophthalmol 51:850–862

    Article  CAS  Google Scholar 

  • Nath R, Meigooni AS, Meli JA (1990) Dosimetry on the transverse axes of I-125 and Ir-192 interstitial brachy-therapy sources. Med Phys 17:1032–1040

    Article  PubMed  CAS  Google Scholar 

  • Newman GH, Davidorf FH, Havener WH et al. (1970) Conservative management of malignant melanoma. Arch Ophthalmol 83:21–26

    Article  PubMed  CAS  Google Scholar 

  • Packer S (1987) Iodine-125 radiation of posterior uveal melanoma. Ophthalmology 94:1621–1626

    PubMed  CAS  Google Scholar 

  • Packer S, Rotman M (1980) Radiotherapy of choroidal melanoma with Iodine-125. Ophthalmology 87:582–590

    PubMed  CAS  Google Scholar 

  • Packer S, Rotman M, Salanitro P (1984) Iodine-125 irradiation of choroidal melanoma: clinical experience. Ophthalmology 91:1700–1708

    PubMed  CAS  Google Scholar 

  • Parsons JT, Fitzgerald Cr, Hood CI et al. (1983) The effects of irradiation on the eye and optic nerve. Int J Radiat Oncol Biol Phys 9:609–622

    Article  PubMed  CAS  Google Scholar 

  • Petrovich Z, Liggett PE, Lean E et al (1990a) Treatment of T3 primary malignant melanoma of the choroid with episcleral radioactive plaque. Endocuriether Hyperthermia Oncol 6:11–17

    Google Scholar 

  • Petrovich Z, Liggett PE, Luxton G et al. (1990b) Radioactive plaque therapy in the management of primary malignant ocular melanoma: an overview. Endocuriether Hyperthermia Oncol 6:131–141

    Google Scholar 

  • Petrovich Z, Luxton G, Langholz B et al. (1992) Episcleral plaque radiotherapy in the treatment of uveal melanomas. Int J Radiat Oncol Biol Phys 24:247–251

    PubMed  CAS  Google Scholar 

  • Petrovich Z, Astrahan MA, Jozsef G et al. (1992) Episcleral plaque thermoradiotherapy in patients with choroidal melanoma. Int J Radiat Oncol Biol Phys 23:599–603

    Article  PubMed  CAS  Google Scholar 

  • Peyman G A, Apple DJ (1974) Local excision of choroidal malignant melanoma. Arch Ophthalmol 92:216–218

    Article  PubMed  CAS  Google Scholar 

  • Rajpal S, Moore R, Karakousis CP (1983) Survival in metastatic ocular melanoma. Cancer 52:334–336

    Article  PubMed  CAS  Google Scholar 

  • Rand RW, Khonsary A, Brown WJ (1989) Leksell stereotactic radiosurgery in the treatment of eye melanoma. Neurol Res 9:142–146

    Google Scholar 

  • Riedel KG, Svitra PP, Seddon JM et al. (1985) Proton beam irradiation and hyperthermia. Effects on experimental choroidal melanoma. Arch Ophthalmol 103:1862–1869

    Article  PubMed  CAS  Google Scholar 

  • Saunders WM, Char DH, Quivey JM et al. (1985) Precision, high dose radiotherapy: helium ion treatment of uveal melanoma. Int J Radiat Oncol Biol Phys 11:227–233

    Article  PubMed  CAS  Google Scholar 

  • Scarborough EC, Koro NC, Antich UT (1988) Substitution of Pd-103 for I-125 in the treatment of choroidal melanomas (abstr). Phys Med Biol 33:128

    Google Scholar 

  • Sealy R, Le Roux PLM, Rapley F et al. (1976) The treatment of ophthalmic tumors with low-energy sources. Br J Radiol 49:551–554

    Article  PubMed  CAS  Google Scholar 

  • Seddon JM, Albert DM, Lavin PT et al. (1983) A prognostic factor study of disease-free interval and survival following enucleation for uveal melanoma. Arch Ophthalmol 101:1894–1899

    Article  PubMed  CAS  Google Scholar 

  • Seigel D, Myers M, Ferris F et al. (1979) Survival rates after enucleation of eyes with malignant melanoma. Am J Ophthalmol 87:761–765

    PubMed  CAS  Google Scholar 

  • Shammas HF, Blodi FC (1977a) Prognostic factors in choroidal and ciliary body melanomas. Arch Ophthalmol 95:63–69

    Article  PubMed  CAS  Google Scholar 

  • Shammas HF, Blodi FC (1977b) Orbital extension of choroidal and ciliary melanomas. Arch Ophthalmol 95:2002–2005

    Article  PubMed  CAS  Google Scholar 

  • Shields JA, McDonald PR (1974) Improvements in the diagnosis of posterior uveal melanomas. Arch Ophthalmol 91:259–264

    Article  PubMed  CAS  Google Scholar 

  • Shields JA, Shields CL (eds) (1992) Management of posterior uveal melanoma in intraocular tumors. WB Saunders, Philadelphia, pp 171–194

    Google Scholar 

  • Shields JA, Zimmerman LE (1973) Lesions simulating malignant melanoma of the posterior uvea. Arch Ophthalmol 89:466–471

    Article  PubMed  CAS  Google Scholar 

  • Shields JA, Augsburger JJ, Brady LW et al. (1982) Cobalt plaque therapy of posterior uveal melanomas. Ophthalmology 89:1201–1207

    PubMed  CAS  Google Scholar 

  • Sinclair WK, Trott NG (1956) The construction and measurement of beta-ray applicators for use in ophthalmology. Br J Surg 29:15–23

    CAS  Google Scholar 

  • Sobanski J, Zeydler-Gredzielewska L, Szusterowska-Martinowa E (1972) Decreased mortality of patients with intraocular malignant melanoma after enucleation of the eyeball followed by orbit x-ray irradiation. Pol Med J 11:1512–1516

    PubMed  CAS  Google Scholar 

  • Spencer WH (1975) Optic nerve extension of intraocular neoplasms. Am J Ophthalmol 80:465–471

    PubMed  CAS  Google Scholar 

  • Stallard HB (1961) Malignant melanoma of the choroid treated with radioactive applicators. Ann R Coll Surg Engl 29:170–182

    PubMed  CAS  Google Scholar 

  • Stallard HB (1966) Radiotherapy for malignant melanoma of the choroid. Br J Ophthalmol 50:147–155

    Article  PubMed  CAS  Google Scholar 

  • Thomas JV, Green WR, Maumenee AE (1979) Small choroidal melanomas: a long term follow-up study. Arch Ophthalmol 97:861–864

    Article  PubMed  CAS  Google Scholar 

  • Vogel MH (1972) Treatment of malignant choroidal melanomas with photocoagulation. Evaluation of 10-year follow-up data. Am J Ophthalmol 74:1–11

    PubMed  CAS  Google Scholar 

  • Weaver KA (1986) The dosimetry of I-125 seed eye plaques. Med Phys 13:78–83

    Article  PubMed  CAS  Google Scholar 

  • Weaver KA, Smith V, Huang D et al. (1989) Dose parameters of I-125 and Ir-192 seed sources. Med Phys 16:636–643

    Article  PubMed  CAS  Google Scholar 

  • Weinhaus RS, Seddon JM, Albert DM et al. (1985) Prognostic factors: study of survival after enucleation for juxtapapillary melanomas. Arch Ophthalmol 103:1673–1677

    Article  PubMed  CAS  Google Scholar 

  • Wright CJE (1949) Prognosis in cutaneous and ocular malignant melanoma: a study of 222 cases. J Pathol Bacteriol 61:507–525

    Article  Google Scholar 

  • Zimmerman LE, McLean IW (1979) An evaluation of enucleation in the management of uveal melanomas. Am J Ophthalmol 87:741–760

    PubMed  CAS  Google Scholar 

  • Zimmerman LE, McLean IW, Foster WD (1978) Does enucleation of the eye containing a malignant melanoma prevent or accelerate the dissemination of tumor cells? Br J Ophthalmol 62:420–425

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Oncology, Kenneth Norris Jr. Cancer Hospital and Research Institute, University of Southern California School of Medicine, 1441 Eastlake Avenue, P.O. Box 33804, Los Angeles, CA, 90033-0804, USA

    Zbigniew Petrovich M.D. (Professor, Chairman), Melvin Astrahan Ph.D. (Assistant Professor) & Gary Luxton Ph.D. (Associate Professor, Director Radiation Physics)

  2. Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Ninth & Walnut Streets, Philadelphia, PA, 19107, USA

    Jerry A. Shields M.D. (Professor, Director) & Carol L. Shields M.D. (Assistant Professor)

  3. Department of Radiation Oncology and Nuclear Medicine, Hahnemann University, Broad & Vine Streets, Mail Stop 200, Philadelphia, PA, 19102-1192, USA

    Luther W. Brady M.D. (Professor, Chairman)

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  1. Zbigniew Petrovich M.D.
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  2. Melvin Astrahan Ph.D.
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  3. Gary Luxton Ph.D.
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  4. Jerry A. Shields M.D.
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  5. Carol L. Shields M.D.
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  6. Luther W. Brady M.D.
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  1. Klinik für Strahlentherapie und Nuklearmedizin, Alfried Krupp Krankenhaus, Alfried Krupp-Straße 21, W-4300, Essen 1, Germany

    Winfried E. Alberti

  2. Radiation Oncology Division, Health Science Center, State University of New York, 750 East Adams Street, Syracuse, NY, 13210, USA

    Robert H. Sagerman M.D., F.A.C.R. (Professor and Director) (Professor and Director)

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Petrovich, Z., Astrahan, M., Luxton, G., Shields, J.A., Shields, C.L., Brady, L.W. (1993). Primary Malignant Melanoma of the Uvea: Radioactive Plaque Therapy and Other Treatment Modalities. In: Alberti, W.E., Sagerman, R.H. (eds) Radiotherapy of Intraocular and Orbital Tumors. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97011-5_5

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