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Radiotherapy of Intraocular and Orbital Tumors pp 387–398Cite as

Morphologic Changes After Iodine-125 Plaque Irradiation of Rabbit Eyes

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Radiation damage to the retina and optic nerve can result in significant impairment of visual acuity and compromise the outcome following radiation therapy of tumors within and around the eye. Radiation retinopathy is characterized by abnormalities of the retinal circulation, including capillary nonperfusion, macular edema, vessel leakage, microaneurysms, and telangiectasia (overview by Alberti 1991). It is assumed that radiation optic neuropathy (RON) is a consequence of damage to the retinal vessels. This assumption is supported by fluorescein angiographic studies. RON can cause acute bilateral or unilateral loss of visual acuity ranging from mild to severe. Radiation retinopathy and RON usually occur within 3 years after treatment; however, latency up to 15 years has been reported (Chaudhuri et al. 1981).

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References

  • Alberti W (1991) Effects of radiation on the eye and ocular adnexa. In: Scherer E, Streffer C, Trott KR (eds) Radiopathology of organs and tissues. Springer, Berlin Heidelberg New York, pp 269–282

    Chapter  Google Scholar 

  • Alberti W, Pothmann B, Tabor P et al. (1991) Dosimetry and physical treatment planning for iodine eye plaque therapy. Int J Radiat Oncol Biol Phys 20:1087–1092

    Article  PubMed  CAS  Google Scholar 

  • Bedford MA, Bedotto C, MacFaul PA (1970) Radiation retinopathy after the application of a cobalt plaque. Br J Ophthalmol 54:505–509

    Article  PubMed  CAS  Google Scholar 

  • Boniuk M, Girard LJ (1965) Malignant melanoma of the choroid. Am J Ophthalmol 59:212–216

    PubMed  CAS  Google Scholar 

  • Brady LW, Shields IA, Augsburger JJ et al. (1990) Choroidal melanoma: role of brachytherapy in management. In: Sauer R (ed) Interventional radiation therapy. Techniques — brachytherapy. Springer, Berlin Heidelberg New York, pp 113–122

    Google Scholar 

  • Char DH, Castro JR, Quivey JM et al. (1989) Uveal melanoma radiation. 125I brachytherapy versus helium ion irradiation. Ophthalmology 96:1708–1715

    PubMed  CAS  Google Scholar 

  • Chaudhuri PR, Austin DJ, Rosenthal AR (1981) Treatment of radiation retinopathy. Br J Ophthalmol 65: 623–625

    Article  PubMed  CAS  Google Scholar 

  • Cruess AF, Augsburger JJ, Shields JA et al. (1984) Visual results following cobalt plaque radiotherapy for posterior uveal melanomas. Ophthalmology 91: 131–136

    PubMed  CAS  Google Scholar 

  • El-Hifnawi ES (1985) Pathomorphologische Untersuchungen zum Verlauf der hereditären Netzhautdystrophie bei R.C.S.-Ratten. Enke, Stuttgart

    Google Scholar 

  • Foerster MH, Bornfeld N, Schulz U et al. (1986) Complications of local beta radiation of uveal melanomas. Graefes Arch Clin Exp Ophthalmol 224:336–340

    Article  PubMed  CAS  Google Scholar 

  • Lommatzsch P, Weise B, Ballin R (1986) Ein Beitrag zur Optimierung der Bestrahlungszeit bei der Behandlung des malignen Melanoms der Aderhaut mit β-Applikatoren (106Ru/106Rh). Klin Monatsbl Augenheilkd 189:133–140

    Article  PubMed  CAS  Google Scholar 

  • McFaul PA, Morgan G (1977) Histopathological changes in malignant melanomas of the choroid after cobalt plaque therapy. Br J Ophthalmol 61:221–228

    Article  Google Scholar 

  • Packer S (1987) Iodine-125 radiation of posterior uveal melanoma. Ophthalmology 12:1621–1626

    Google Scholar 

  • Packer S, Rotman M, Salanitro P (1984) Iodine-125 irradiation of choroidal melanoma. Clinical experience. Ophthalmology 12:1700–1708

    Google Scholar 

  • Prince JH, Diesem CD, Eglitis I et al. (1960) Anatomy and histology of the eye and orbit in domestic animals. Charles C. Thomas, Springfield, Ill, pp 260–297

    Google Scholar 

  • Reynolds ES (1963) The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol 17:208–212

    Article  PubMed  CAS  Google Scholar 

  • Richardson KC, Jarett L, Finke BH (1960) Embedding in epoxy resins for ultrathin sectioning in electron misroscopy. Stain Technol 35:313–323

    PubMed  CAS  Google Scholar 

  • Shields JA, Augsburger JJ, Brady LW, Day IL (1982) Cobalt plaque theapy for posterior uveal melanomas. Ophthalmology 89:1201–1207

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Clinic for Radiation Therapy and Nuclear Medicine, Alfried Krupp Hospital, Alfried Krupp-Strasse 21, W-4300, Essen 1, Germany

    Winfried E. Alberti M.D., Priv.-Doz.

  2. Eye Clinic, University of Lübeck, Ratzeburger Allee 160, W-2400, Lübeck 1, Germany

    El-Sayed El-Hifnawi M.D. (Professor)

Authors
  1. Winfried E. Alberti M.D., Priv.-Doz.
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  2. El-Sayed El-Hifnawi M.D.
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Editor information

Editors and Affiliations

  1. Klinik für Strahlentherapie und Nuklearmedizin, Alfried Krupp Krankenhaus, Alfried Krupp-Straße 21, W-4300, Essen 1, Germany

    Winfried E. Alberti

  2. Radiation Oncology Division, Health Science Center, State University of New York, 750 East Adams Street, Syracuse, NY, 13210, USA

    Robert H. Sagerman M.D., F.A.C.R. (Professor and Director) (Professor and Director)

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© 1993 Springer-Verlag Berlin Heidelberg

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Alberti, W.E., El-Hifnawi, ES. (1993). Morphologic Changes After Iodine-125 Plaque Irradiation of Rabbit Eyes. In: Alberti, W.E., Sagerman, R.H. (eds) Radiotherapy of Intraocular and Orbital Tumors. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97011-5_39

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  • DOI: https://doi.org/10.1007/978-3-642-97011-5_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-97013-9

  • Online ISBN: 978-3-642-97011-5

  • eBook Packages: Springer Book Archive

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