Conjunctival Tumors and Their Radiotherapy

  • Peter K. Lommatzsch
Part of the Medical Radiology book series (MEDRAD)


The conjunctiva is often affected by neoplasms and by lesions that may simulate neoplasms, especially in elderly patients. This discussion of conjunctival tumors and their radiotherapy will follow the nomenclature, definition, and classification suggested by Zimmerman and Sobin (1980) in volume 24 of the World Health Organization International Classification of Tumors. Most of the conditions listed in this outline, such as Pinguecula, corneal celloid, dermoid, dermolipoma, episcleral osseous choristoma, complex choristoma, benign epithelial tumors, and the inflammatory tumor-like lesions should not be treated by radiotherapy, and are mentioned briefly for systematic reasons. However, lesions such as recurrent pterygium, malignant epithelial tumors, tumors and tumor-like lesions of the melanogenic system, and tumors and tumor-like lesions of the hematopoietic and lymphoid tissues are worthwhile targets for radiotherapy.


Local Excision Pleomorphic Adenoma Invasive Squamous Cell Carcinoma Conjunctival Epithelium Adnexal Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Brownstein S (1980) Mucoepidermoid carcinoma of the conjunctiva with intraocular invasion. Ophthalmology 88:1226–1230Google Scholar
  2. Cameron ME (1972) Preventable complications of pterygium excision with beta-irradiation. Br J Ophthalmol 56:52–56PubMedCrossRefGoogle Scholar
  3. Cerezo L, Otero J, Aragón G, Polo E, de la Torre A, Valcárcel F, Magallón R (1989) Conjunctival intraepithelial and invasive squamous cell carcinoma treated with strontium-90. Radiother Oncol 17:191–197CrossRefGoogle Scholar
  4. Char DH (1989) Clinical ocular oncology. Churchill Livingstone, New York, pp 63–87Google Scholar
  5. Clark WH, Folberg AM (1979) Tumor Progression in primary human cutaneous malignant melanomas. In: Clark WH Jr (ed) Human malignant melanoma. Grune & Stratton, New York, pp 15–31Google Scholar
  6. Cooper JS, Fried PR (1988) Treatment of aggressive epidemic Kaposi’s sarcoma of the conjunctiva by radiotherapy. Arch Ophthalmol 106:20–21PubMedCrossRefGoogle Scholar
  7. David E, Constable WC (1979) The use of strontium-90 in the treatment of carcinoma in situ of the conjunctiva. Am J Ophthalmol 87:84–86Google Scholar
  8. Dutton JJ, Anderson RL, Tse DT (1984) Combined surgery and cryotherapy for scleral invasion of epithelial malignancies. Ophthalmic Surg 15:289–294PubMedGoogle Scholar
  9. Elkon D, Constable WC (1979) The use of strontium-90 in the treatment of carcinoma in situ of the conjunctiva. Am J Ophthalmol 87:84–86PubMedGoogle Scholar
  10. Farrell PLR, Smith RE (1989) Bacterial corneoscleritis complicating pterygium excision. Am J Ophthalmol 107:515–517PubMedGoogle Scholar
  11. Folberg R, McLean IW, Zimmerman LE (1985) Malignant melanoma of the conjunctiva. Human Pathol 16:136–143CrossRefGoogle Scholar
  12. Fraunfelder FT, Wingfield D (1983) Management of intraepithelial conjunctival tumors and squameous cell carcinomas. Am J Ophthalmol 95:359–363PubMedGoogle Scholar
  13. Henkind P (1978) Conjunctival melanocytic lesions: natural history. In: Jakobiec FA (ed) Ocular and adnexal tumors. Aesculapius, Birmingham, Alabama, pp 572–582Google Scholar
  14. Hilgers JM (1960) Prevention of recurrent pterygium by beta-radiation. Ophthalmologica 140:369–379PubMedCrossRefGoogle Scholar
  15. Howard GM, Jakobiec FA, De Voe A (1975) Kaposi’s sarcoma of the conjunctiva. Am J Ophthalmol 79:420–423PubMedGoogle Scholar
  16. Iliff WJ, Marback R, Green WR (1975) Invasive squamous cell carcinoma of the conjunctiva. Arch Ophthalmol 93:119–122PubMedCrossRefGoogle Scholar
  17. Jakobiec FA (1981) Conjunctival melanoma: unfinished business. Arch Ophthalmol 98:1378–1384CrossRefGoogle Scholar
  18. Kleis W, Pico G (1973) Thio-TEPA therapy to prevent postoperative pterygium occurrence and neovascularization. Am J Ophthalmol 76:371–374PubMedGoogle Scholar
  19. Lederman M (1972) Radiotherapy. In: Sorsby A (ed) Modern ophthalmology, 2nd edn, vol 4. Butterworth, London, pp 887–900Google Scholar
  20. Lommatzsch P (1976) Beta-ray treatment of malignant epithelial tumors of the conjunctiva. Am J Ophthalmol 81:198–206PubMedGoogle Scholar
  21. Lommatzsch P (1978) Beta-ray treatment of malignant epibulbar melanoma. Albrecht v. Graefes Arch Klin Exp Ophthalmol 209:111–124CrossRefGoogle Scholar
  22. Lommatzsch P, Fürst G, Vollmar R, Schmidt H (1977) Die therapeutische Anwendung von ionisierenden Strahlen in der Augenheilkunde. In: Velhagen K (ed) Der Augenarzt, 1st edn, vol 4. VEB Georg Thieme, LeipzigGoogle Scholar
  23. Lommatzsch PK, Welker KE, Hüttner J, Bauke G (1982) Die Anwendung von hochenergetischen Elektronen bei der Behandlung von malignen Orbitatumoren. Klin Monatsbl Augenheilkd 180:198–202PubMedCrossRefGoogle Scholar
  24. Lommatzsch PK, Lommatzsch RE, Kirsch I, Fuhrmann P (1990) Therapeutic outcome of patients suffering from malignant melanomas of the conjunctiva. Br J Ophthalmol 74:615–619PubMedCrossRefGoogle Scholar
  25. Morgan G, Harry J (1978) Lymphocytic tumours of indeterminate nature. A 5-year follow-up of 98 conjunctival and orbital lesions. Br J Ophthalmol 62:381–383PubMedCrossRefGoogle Scholar
  26. Pizarello LD, Jakobiec FA (1978) Bowen’s disease of the conjunctiva: a misnomer. In: Jakobiec FA (ed) Ocular and adnexal tumors. Aesculapius, Birmingham, Alabama, p 553Google Scholar
  27. Reese AB (1976) Tumors of the eye, 3rd edn. Harper & Row, HagerstownGoogle Scholar
  28. Reich H, Hollwich F, Uthoff D (1985) Kaposi-Sarkom und AIDS. Klin Monatsbl Augenheilkd 187:1–8PubMedCrossRefGoogle Scholar
  29. Spencer WH, Zimmerman LE (1985) Conjunctiva. In: Spencer WH (ed) Ophthalmic pathology. An atlas and textbook, vol 1. WB Saunders, Philadelphia, pp 192–220Google Scholar
  30. Sundmacher R, Mackensen G (1988) Chirurgie der Konjunktiva und der Sklera. In: Mackensen G, Neubauer H (eds) Augenärztliche Operation 1. Springer, Berlin Heidelberg New York, pp 333–382Google Scholar
  31. Tarr KH, Constable IJ (1980) Late complications of pterygium treatment. Br J Ophthalmol 64:496–505PubMedCrossRefGoogle Scholar
  32. Thiel HJ (1979) Die Anwendung von Beta-Strahlern bei nichttumorösen Prozessen des vorderen Augenabschnittes. Ber Dtsch Ophthalmol Ges 76:283–288Google Scholar
  33. Zimmerman LE (1978) The histogenesis of conjunctival melanomas. In: Jakobiec FA (ed) Ocular and adnexal tumors. Aesculapius, Birmingham, Alabama, pp 572–582Google Scholar
  34. Zimmerman LE, Sobin LH (1980) International histological classification of tumours Nr. 24. Histological typing of tumours of the eye and its adnexa. World Health Organization, GenevaGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Peter K. Lommatzsch
    • 1
  1. 1.Eye ClinicUniversity of LeipzigLeipzigGermany

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