Abstract
Retinoblastoma is a primitive neuroectodermal tumor of the retina, which in view of its histopathologic as well as clinical characteristics has to be regarded as a specific clinical entity (Becker and Hinton 1983). The term “retinoblastoma” dates back to 1926, when it was suggested by Verhoeff after about 100 years of confusing terminology (Verhoeff and Jackson 1926), and refers to its development from primitive precursor cells of the retina (Dunphy 1964). A “benign” variant of retinoblastoma has been described as “retinoma” or “retinocytoma”; these are highly differentiated tumors with basically no growth potential (Gallie et al. 1982; Margo et al. 1983). The term “glioma of the retina” is no longer in use in view of the current understanding of the histogenesis of this tumor.
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References
Becker LE, Hinton D (1983) Primitive neuroectodermal tumors of the central nervous system. Hum Pathol 14:538–550
Bullock JD, Campbell RJ, Waller RR (1977) Calcification in retinoblastoma. Invest Ophthalmol Vis Sci 16:252–255
Bunt AH, Tso MOM (1981) Feulgen-positive deposits in retinoblastoma. Incidence, composition and ultrastructure. Arch Ophthalmol 99:144–150
Dunphy EB (1964) The story of retinoblastoma. The XX Edward Jackson memorial lecture. Trans Am Acad Ophthalmol Otol 68:249–264
Flexner S (1891) A peculiar glioma (neuroepithelioma?) of the retina. J Hopkins Hosp Bull 15:115–119
Gallie BL, Phillips RA, Ellsworth RM, Abramson DH (1982) Significance of retinoma and phthisis bulbi for retinoblastoma. Ophthalmology 89:1393–1399
Koch A, Gerke E, Höpping W (1983) Echography in retinoblastoma. Graefe’s Arch Clin Exp Ophthalmol 221:27–30
Kopelman JE, McLean IW, Rosenberg SH (1987) Multivariate analysis of risk factors for metastasis in retinoblastoma tested by enucleation. Ophthalmology 94:371–377
Kyritsis AP, Tsokos M, Triche TJ, Chader GJ (1984) Retinoblastoma — origin from a primitive neuroectodermal cell? Nature 307:471–473
Margo C, Hidayat A, Kopelman J, Zimmerman LE (1983) Retinocytoma: a benign variant of retinoblastoma. Arch Ophthalmol 101:1519–1531
Menocal NG, Ventura DB, Yanoff M (1980) Eye technics. Routine processing of ophthalmic tissue for light microscopy. In: Sheehan DC, Hrapchak BB (eds) Theory and practice of histotechnology. Mosby, St. Louis, pp 285–291
Messmer EP, Font RL, Kirkpatrick JB, Höpping W (1985) Immunohistochemical demonstration of neuronal and astrocytic differentiation in retinoblastoma. Ophthalmology 92:167–173
Messmer EP, Heinrich T, Höpping W, Havers W, Sauerwein W (1990) Risk factors for metastases in patients with retinoblastoma. Ophthalmology (to be published)
Mullaney J (1969) Retinoblastomas with DNA precipitation. Arch Ophthalmol 82:454–456
Murphree AL (1989) Retinoblastoma. In: Ryan S (ed) Retina. Mosby, St. Louis, pp 517–556
Nicholson DH, Norton EWD (1980) Diffuse infiltrating retinoblastoma. Trans Am Ophthalmol Soc 78:265–289
Redler LD, Ellsworth RM (1973) Prognostic importance of choroidal invasion in retinoblastoma. Arch Ophthalmol 90:294–296
Rootman J. Hofbauer J, Ellsworth RM, Kitchen D (1976) Invasion of the optic nerve by retinoblastoma: a clinicopathological study. Can J Ophthalmol 11:106–114
Rootman J, Ellsworth RM, Hofbauer J, Kitchen D (1978) Orbital extension of retinoblastoma: a clinicopathological study. Can J Ophthalmol 13:72–88
Sang DN, Albert DM (1982) Retinoblastoma: clinical and histopathologic features. Hum Pathol 13:133–147
Schofield PB (1960) Diffuse infiltrating retinoblastoma. Br J Ophthalmol 44:35–41
Tso MOM, Zimmerman LE, Fine BS (1970a) The nature of retinoblastoma. I. Photoreceptor differentiation: a clinical and histopathologic study. Am J Ophthalmol 69:339–349
Tso MOM, Fine BS, Zimmerman LE (1970b) The nature of retinoblastoma. II. Photoreceptor differentiation: an electron microscopic study. Am J Ophthalmol 69:350–359
Verhoeff FH, Jackson E (1926) Minutes of the proceedings. Sixty-second annual meeting. Trans Am Ophthalmol Soc 24:38–43
Wintersteiner H (1897) Aetiologische Momente und Hypothesen über die Entstehung des Neuroepithelioma retinae. In: Wintersteiner H (ed) Das Neuroepithelioma retinae. Deuticke, Leipzig, pp 189–200
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© 1993 Springer-Verlag Berlin Heidelberg
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Messmer, E.P. (1993). Histopathology of Retinoblastoma. In: Alberti, W.E., Sagerman, R.H. (eds) Radiotherapy of Intraocular and Orbital Tumors. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97011-5_14
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DOI: https://doi.org/10.1007/978-3-642-97011-5_14
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