Multiple myeloma (plasmocytoma, myelomatosis) is a disease resulting from the uncontrolled proliferation of one or more clones of plasma (myeloma) cells. In most instances, the bone marrow is diffusely infiltrated by myeloma cells, but localised bone involvement or extraosseous manifestation occurs as well. The uncontrolled proliferation of myeloma cells usually goes along with an increased synthesis of a homogeneous-immu-noglobulin molecule and/or one of its constituent polypeptide chains. The disease is typically associated with bone destruction, humoral immunodeficiency, susceptibility to infections, bleeding, impairment of renal function and hypercalcaemia. Multiple myeloma is not curable, but worthwhile palliative treatment with prolongation of survival is available for some patients.
KeywordsMultiple Myeloma Plasma Cell Light Chain Myeloma Cell Uncontrolled Proliferation
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