Mesenchymal Tumor, Kidney, Rat

  • Gordon C. Hard
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Small tumors are visible at one pole or at the curvature of the intact kidney as white discoloration on the surface. Such lesions are usually confined to the outer zones of the organ as an ill-defined infiltrative growth following the sagittal plane of the cortex and without the rounded form which typifies epithelial tumors of the kidney (Fig. 31). A poorly delineated tumor outline is characteristic and particularly evident when the kidney is prepared as a histologic section. The texture of the small to intermediate-sized tumors is usually fibrous and sometimes they are obviously cystic (Fig. 31). In some cases at autopsy the affected kidney appears uniformly enlarged, and when sectioned, the tumor tissue is found to be distributed throughout much of the organ. In larger tumors, proliferation occurs beyond the kidney outline to form bulging nodular masses (Fig.32) which may reach an immense size and fill the abdominal cavity. Very large tumors are usually multilobular, with prominent areas of hemorrhage, necrosis, and gelatinous tissue. Despite the destruction of kidney substance in these cases, invariably a small rim of normal renal parenchyma remains intact at some point on the surface of the tumor.


Spindle Cell Mesenchymal Tumor Smooth Muscle Fiber Mesoblastic Nephroma Congenital Mesoblastic Nephroma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Argus MF, Hoch-Ligeti C (1961) Comparative study of the carcinogenic activity of nitrosamines. JNCI 27: 695–709PubMedGoogle Scholar
  2. Bolande RP, Brough AJ, Izant RI Jr (1967) Congenital mesoblastic nephroma of infancy. A report of eight cases and the relationship to Wilms’ tumor. Pediatrics 40: 272–278PubMedGoogle Scholar
  3. Fitts RH (1960) Bilateral feline embryonal sarcoma. J Am Vet Med Assoc 136: 616PubMedGoogle Scholar
  4. Guérin M (1954) Tumeurs spontanées des animaux de laboratoire (souris-rat-poule). Legrand, Paris, pp 100–102Google Scholar
  5. Guérin M, Chouroulinkov I, Rivière MR (1969) Experimental kidney tumours. In: Rouiller C, Muller AF (eds) The kidney: morphology, biochemistry, physiology, vol 2. Academic, New York, pp 199–268Google Scholar
  6. Gusek W (1968) Feinstruktur und Differenzierung experimenteller Wilmstumoren. Verh Dtsch Ges Pathol 52: 410–415PubMedGoogle Scholar
  7. Gusek W, Buss H, Laqueur GL (1967) Histologisch-histochemische Untersuchungen am Interstitiellen CycasinTumor’ der Rattenniere. Beitr Pathol Anat Allg Pathol 135: 53–74Google Scholar
  8. Hadjiolov D (1968) Induction of nephroblastomas in the rat with dimethylnitrosamine. Z Krebsforsch 71: 59–62PubMedCrossRefGoogle Scholar
  9. Hara H, Miyao M, Moriki T, Kutsukake F, Yamane T (1982) Histological and ultrastructural studies of nephroblastoma in rats induced transplacentally by ethylnitrosourea. Acta Pathol Jpn 32: 385–398PubMedGoogle Scholar
  10. Hard GC (1976) Tumours of the kidney, renal pelvis and ureter. IARC Sci Publ 6: 73–102PubMedGoogle Scholar
  11. Hard GC (1979) Effect of age at treatment on incidence and type of renal neoplasm induced in the rat by a single dose of dimethylnitrosamine. Cancer Res 39: 4965–4970PubMedGoogle Scholar
  12. Hard GC (1984) Comparative oncology: II. Nephroblastoma in domesticated and wild animals. In: Pochedly C, Baum ES (eds) Wilms’ tumor: clinical and biological manifestations. Elsevier, New York, pp 169–189Google Scholar
  13. Hard GC (1985) Differential renal tumor response to Nethylnitrosourea and dimethylnitrosamine in the Nb rat: basis for a new rodent model of nephroblastoma. Carcinogenesis 6: 1551–1558PubMedCrossRefGoogle Scholar
  14. Hard GC, Butler WH (1970a) Cellular analysis of renal neoplasia: induction of renal tumors in dietary-conditioned rats by dimethylnitrosamine with a reappraisal of morphological characteristics. Cancer Res 30: 2796–2805Google Scholar
  15. Hard GC, Butler WH (1970b) Cellular analysis of renal neoplasia: light microscope study of the development of interstitial lesions induced in the rat kidney by a single carcinogenic dose of dimethylnitrosamine. Cancer Res 30: 2806–2815Google Scholar
  16. Hard GC, Butler WH (1971a) Ultrastructural study of the development of interstitial lesions leading to mesenchymal neoplasia induced in the rat renal cortex by dimethylnitrosamine. Cancer Res 31: 337–347Google Scholar
  17. Hard GC, Butler WH (1971b) Ultrastuctural analysis of renal mesenchymal tumor induced in the rat by dimethylnitrosamine. Cancer Res 31: 348–365Google Scholar
  18. Hard GC, Butler WH (1971c) Ultrastructural aspects of renal adenocarcinoma induced in the rat by dimethylnitrosamine. Cancer Res 31: 366–372Google Scholar
  19. Hard GC, Grasso P (1976) Nephroblastoma in the rat; histology of a spontaneous tumor, identity with respect to renal mesenchymal neoplasms, and a review of previously recorded cases. JNCI 57: 323–329PubMedGoogle Scholar
  20. Hard GC, Noble RL (1981) Occurrence, transplantation, and histologic characteristics of nephroblastoma in the Nb hooded rat. Invest Urol 18: 371–376PubMedGoogle Scholar
  21. Horton L, Fox C, Corrin B, Sönksen PH (1977) Streptozotocin-induced renal tumours in rats. Br J Cancer 36: 692–699PubMedCrossRefGoogle Scholar
  22. Ito N, Hiasa Y, Kamamoto Y, Makiura S, Sugihara S, Marugami M, Okajima E (1971) Histopathological analysis of kidney tumors in rats induced by chemical carcinogens. Gann 62: 435–444PubMedGoogle Scholar
  23. Jones SR, Casey HW (1981) Primary renal tumors in nonhuman primates. Vet Pathol 18 [supp16]: 89–104PubMedGoogle Scholar
  24. Laqueur GL, Matsumoto H (1966) Neoplasms in female Fischer rats following intraperitoneal injection of methylazoxymethanol. JNCI 37: 217–232PubMedGoogle Scholar
  25. Laqueur GL, Mickelsen O, Whiting MG, Kurland LT (1963) Carcinogenic properties of nuts from Cycas circinalis, L. indigenous to Guam. JNCI 31: 919–951PubMedGoogle Scholar
  26. Leaver DD, Swann PF, Magee PN (1969) The induction of tumours in the rat by a single oral dose of N-nitrosomethylurea. Br J Cancer 23: 177–187PubMedCrossRefGoogle Scholar
  27. Magee PN, Barnes JM (1962) Induction of kidney tumours in the rat with dimethylnitrosamine (N-nitrosodimethylamine). J Pathol Bacteriol 84: 19–31PubMedCrossRefGoogle Scholar
  28. Marsden HB, Lawler W (1980) Bone-metastasizing renal tumor of childhood. Histopathological and clinical review of 38 cases. Virchows Arch [A] 387: 341–351CrossRefGoogle Scholar
  29. McLean AEM, Magee PN (1970) Increased renal carcinogenesis by dimethyl nitrosamine in protein deficient rats. Br J Exp Pathol 51: 587–590PubMedGoogle Scholar
  30. Riopelle JL, Jasmin G (1969) Nature, classification and nomenclature of kidney tumors induced in the rat by dimethylnitrosamine. JNCI 42: 643–662PubMedGoogle Scholar
  31. SunterJP, Senio PV (1983) Induction of renal tumours in rats by the administration of 1,2-dimethylhydrazine. J Pathol 140: 69–76CrossRefGoogle Scholar
  32. Swann PF, Magee PN (1969) Induction of rat kidney tumours by ethyl methanesulphonate and nervous tissue tumours by methyl methanesulphonate and ethyl methanesulphonate. Nature 223: 947–949PubMedCrossRefGoogle Scholar
  33. Turusov VS, Alexandrov VA, Timoshenko IV (1980) Nephroblastoma and renal mesenchymal tumor induced in rats by N-nitrosoethyl-and N-nitrosomethylurea. Neoplasma 27: 229–235PubMedGoogle Scholar
  34. Yang YH (1966) Renal hyperplasia and neoplasia in rats given dimethylnitrosamine. Urol Int 21: 229–238PubMedCrossRefGoogle Scholar
  35. Zak FG, Holzner JH, Singer EJ, Popper H (1960) Renal and pulmonary tumors in rats fed dimethylnitrosamine. Cancer Res 20: 96–99PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Gordon C. Hard

There are no affiliations available

Personalised recommendations