Urinary System pp 291-310 | Cite as

Hyperplasia, Urinary Bladder, Rat

  • E. Kunze
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The epithelium of the urinary bladder of rats is a slowly renewing tissue with a very low cell turnover. However, urothelium is capable of proliferating to a considerable extent. Urothelial hyperplasia represents a common proliferative lesion of the bladder induced by a great variety of conditions. Histologically, several types of hyperplasia differing by growth pattern and cellular differentiation can be observed. From an etiologic point of view two basic types need to be distinguished: non-neoplastic and pre-neoplastic hyperplasia.


Urinary Bladder Focal Nodular Hyperplasia Urothelial Cell Bladder Urothelium Bladder Epithelium 
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  1. Adolphs HD, Thiele J, Kiel H, Steffens E (1978) Induction of transitional cell carcinoma of urinary bladder in rats by feeding N [4-(5-nitro-2-fury1)-2-thiazolyl] formamide. Urol Res 6: 19–27PubMedCrossRefGoogle Scholar
  2. Adolphs HD, Thiele J, Vahlensieck W (1979) Harnblasentumoren unter Berücksichtigung experimenteller Befunde zur Pathomorphogenese, Prophylaxe and Therapie. Steinkopff, DarmstadtGoogle Scholar
  3. Akaza H, Murphy WM, Soloway MS (1984) Bladder cancer induced by noncarcinogenic substances. J Uro 1131: 152–155Google Scholar
  4. Anderström C, Johansson SL (1983) The combined effect of mechanical trauma and phenacetin or sodium saccharin on the rat urinary bladder. Acta Pathol Microbiol Immunol Scand [A] 26: 480–495Google Scholar
  5. Angrist A, Capurro P, Moumgis B (1960) Studies on squamous metaplasia in rat bladder. II. Effects of estradiol and estradiol plus hexestrol. Cancer Res 20: 568–572PubMedGoogle Scholar
  6. Antonakopoulos GN, Hicks RM, Hamilton E, Berry RJ (1982) Early and late morphological changes (including carcinoma of the urothelium) induced by irradiation of the rat urinary bladder. Br J Cancer 46: 403–416PubMedCrossRefGoogle Scholar
  7. Arai M, Kani T, Sugihara S, Matsumura K, Miyata Y, Shinohara Y, Ito N (1974) Scanning and transmission electron microscopy of changes in the urinary bladder in rats treated with N-butyl-N(4-hydroxybutyl)-nitrosamine. Gann 65: 529–540PubMedGoogle Scholar
  8. Arai M, Cohen SM, Jacobs JB, Friedell GH (1979) Effect of dose on urinary bladder carcinogenesis induced in F344 rats by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. JNCI 62: 1013–1016PubMedGoogle Scholar
  9. Ba II JK, Field WEH, Roe FJC, Walters M (1964) The carcinogenic and co-carcinogenic effects of paraffin wax pellets and glass beads in the mouse bladder. Br J Uro 136: 225–237Google Scholar
  10. Bonser GM, Clayson DB (1964) A sulphonamide derivate which induced urinary tract epithelial hyperplasia and carcinomas of the bladder epithelium in the mouse. Br J Uro 136: 26–34CrossRefGoogle Scholar
  11. Bonser GM, Clayson DB, Jull JW, Pyrah LN (1953) The induction of tumours of the bladder epithelium in rats by the implantation of paraffin wax pellets. Br J Cancer 7: 456–459PubMedCrossRefGoogle Scholar
  12. Capurro P, Angrist A, Black J, Moumgis B (1960) Studies in squamous metaplasia in rat bladder. I. Effects of hypovitaminosis A, foreign bodies, and methylcholanthrene. Cancer Res 20: 563–567PubMedGoogle Scholar
  13. Chaves E (1968) Induction of bladder hyperplasia in rats after a single dose of cyclophosphamide. Rev Tranc Etudes Clin et Bio 113: 56–61Google Scholar
  14. Chowaniec J, Hicks RM (1979) Response of the rat to saccharin with particular reference to the urinary bladder. Br J Cancer 39: 355–375PubMedCrossRefGoogle Scholar
  15. Clayson DB, Bonser GM (1965) The induction of tumours of the mouse bladder epithelium by 4-ethylsulphonyl-naphthalene-1-sulphonamide. Br J Cancer 19: 311–316PubMedCrossRefGoogle Scholar
  16. Clayson DB, Lawson TA, Santana S, Bonser GM (1965) Correlation between the chemical induction of hyperplasia and of malignancy in the bladder epithelium. Br J Cancer 19: 297–310PubMedCrossRefGoogle Scholar
  17. Clayson DB, Pringle JAS, Bonser GM (1967) 4-Ethylsulphonylnaphthalene-1-sulphonamide: a new chemical for the study of bladder cancer in the mouse. Biochem Pharmacol 16: 619–626PubMedCrossRefGoogle Scholar
  18. Cohen SM, Jacobs JB, Arai M, Johansson S, Friedell GH (1976a) Early lesions in experimental bladder cancer: experimental design and light microscopic findings. Cancer Res 36: 2508–2511PubMedGoogle Scholar
  19. Cohen SM, Wittenberg JF, Bryan GT (1976b) Effect of avitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N-[4-(5-nitro-s-furyl)-2-thiazolyl] formamide. Cancer Res 36: 2334–2339Google Scholar
  20. Cohen SM, Arai M, Jacobs JB, Friedell GH (1979) Promoting effect of saccharin and DL-tryptophan in urinary bladder carcinogenesis. Cancer Res 39: 1207–1217PubMedGoogle Scholar
  21. Cohen SM, Murasaki G, Fukushima S, Greenfield RE (1982) Effect of regenerative hyperplasia on the urinary bladder: carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. Cancer Res 42: 65–71PubMedGoogle Scholar
  22. Cooper CH, Cowen DM, Knowles JC (1972) The recovery of mouse bladder epithelium after injury by 4-ethylsulphonylnaphthalene 1-sulphonamide. J Pathol 108: 151–156PubMedCrossRefGoogle Scholar
  23. Daskal Y, Soloway MS, De Furia MD, Crooke ST (1980) Morphological effects of mitomycin C administered intravesically to normal mice and mice with N-[4-(5-nitro2-furyl)-2-thiazolyl]formamide-induced bladder neoplasms. Cancer Res 40: 261–267PubMedGoogle Scholar
  24. Davis CP, Cohen SM, Gruber MB, Anderson MD, Warren MM (1984) Urothelial hyperplasia and neoplasia: a response to chronic urinary tract infections in rats. J Uro 1132: 1025–1031Google Scholar
  25. Ertürk E, Cohen SM, Price JM, Bryan GT (1969) Pathogenesis, histology and transplantability of urinary bladder carcinomas induced in albino rats by oral administration of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. Cancer Res 29: 2219–2228PubMedGoogle Scholar
  26. Fitzhugh OG (1959) Chronic oral toxicity of 4stearic acid emulsifiers. Toxicol Appl Pharmaco 11: 315–331CrossRefGoogle Scholar
  27. Fitzhugh OG, Nelson AA (1946) Comparison of the chronic toxicity of triethylene glycol with that of diethylene glycol. J Indust Hyg 28: 40–43PubMedGoogle Scholar
  28. Fukushima S, Cohen SM (1980) Saccharin-induced hyperplasia of the rat urinary bladder. Cancer Res 40: 734–736PubMedGoogle Scholar
  29. Fukushima S, Arai M, Cohen SM, Jacobs JB, Friedell GH (1981a) Scanning electron microscopy of cyclophosphamide-induced hyperplasia of the rat urinary bladder. Lab Invest 44: 89–96PubMedGoogle Scholar
  30. Fukushima S, Cohen SM, Arai M, Jacobs JB, Friedell GH (1981b) Scanning electron microscopic examination of reversible hyperplasia of the rat urinary bladder. Am J Pathol 102: 373–380PubMedGoogle Scholar
  31. Fukushima S, Murasaki G, Hirose M, Nakanishi K, Hasegawa R, Ito N (1982) Histopathological analysis of preneoplastic changes during N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder carcinogenesis in rats. Acta Pathol Jpn 32: 243–250PubMedGoogle Scholar
  32. Fukushima S, Hagiwara A, Ogiso T, Shifata M, Ito N (1983) Promoting effect of various chemicals in rat urinary bladder carcinogenesis initiated by N-nitroso-n-butyl(4-hydroxybutyl)-amine. Fd Chem Toxic 21: 59–68CrossRefGoogle Scholar
  33. Green U, Rippel W (1979) Bladder calculi in rats treated with nitrosomethylurea and fed artificial sweeteners. Exp Pathol 17: 561–564Google Scholar
  34. Hainau B (1979) Luminal plasma membrane organization in rat urinary bladder urothelium after direct exposure in vivo to N-methyl-N-nitrosourea. Cancer Res 39: 3757–3762PubMedGoogle Scholar
  35. Hedenberg I (1954) Macroscopic and microscopic changes and stone formation in the urinary tract in experimentally produced vitamin A deficiency in rats. Acta Chir Scand 192: 1–87Google Scholar
  36. Hicks RM (1969) Nature of the keratohyalin-like granules in hyperplastic and cornified areas of transitional epithelium in the vitamin A-deficient rat. J Anat 104: 327–339PubMedGoogle Scholar
  37. Hicks RM (1970) Early changes in the fine structure of rat bladder epithelium induced by 4-ethylsulphonylnaphthalene-1-sulphonamide. Chem Biol Interact 1: 49–71CrossRefGoogle Scholar
  38. Hicks RM (1980) Multistage carcinogenesis in the urinary bladder. Br Med Bull 35: 39–46Google Scholar
  39. Hicks RM, Chowaniec J (1977) The importance of synergy between weak carcinogens in the induction of bladder cancer in experimental animals and humans. Cancer Res 37: 2943–2949PubMedGoogle Scholar
  40. Hicks RM, Wakefield JSJ (1972) Rapid induction of bladder cancer in rats with N-methyl-N-nitrosourea. I. Histology. Chem Biol Interact 5: 139–152PubMedCrossRefGoogle Scholar
  41. Hicks RM, Wakefield JSJ (1976) Membrane changes during urothelial hyperplasia and neoplasia. Cancer Res 36: 2502–2507PubMedGoogle Scholar
  42. Hicks RM, Wakefield JSJ, Chowaniec J (1975) Evaluation of a new model to detect bladder carcinogens or co-carcinogens; results obtained with saccharin cyclamate and cyclophosphamide. Chem Biol Interact 11: 225–233PubMedCrossRefGoogle Scholar
  43. Hicks RM, Wright R, Wakefield JSJ (1982) The induction of rat bladder cancer by 2-napththylamine. Br J Cancer 46: 646–661PubMedCrossRefGoogle Scholar
  44. Highman B, Frith CH, Littlefield NA (1975) Alkaline phosphatase activity in hyperplastic and neoplastic urinary bladder epithelium of mice fed 2-acetylaminofluorene. JNCI 54: 257–261PubMedGoogle Scholar
  45. Hodges GM, Hicks RM, Spacey GD (1976) Scanning electron microscopy of cell-surface changes in methylnitrosurea ( MNU)-treated rat bladder in vivo and in vitro. Differentiation 6: 143–160PubMedCrossRefGoogle Scholar
  46. Isaka H, Yoshii H, Otsuji A, Koike M, Nagai Y, Koura M, Sugiyasu K, Kanabayashi T (1979) Tumors of SpragueDawley rats induced by long-term feeding of phenacetin. Gann 70: 29–36PubMedGoogle Scholar
  47. Ito N (1976) Early changes caused by N-butyl-N-(4-hydroxybutyl)-nitrosamine in the bladder epithelium of different animal species. Cancer Res 36: 2528–2531PubMedGoogle Scholar
  48. Ito N, Hiasa Y, Tamai A, Okajima E, Kitamura H (1969) Histogenesis of urinary bladder tumors induced by Nbutyl-N-(4-hydroxybutyl)-nitrosamine in rats. Gann 60: 401–410PubMedGoogle Scholar
  49. Ito N, Matayoshi K, Arai M, Yoshioka Y, Kamamoto Y, Makiura S, Sugihara S (1973) Effect of various factors on induction of urinary bladder tumors in animals by Nbutyl-N-(4-hydroxybutyl)-nitrosamine. Gann 64: 151–159PubMedGoogle Scholar
  50. Ito N, Arai M, Sugihara S, Hirao K, Makiura S, Matayoshi K, Denda A (1975) Experimental urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine. Gann Monogr Cancer Res 17: 367–381Google Scholar
  51. Ito N, Shirai T, Fukushima S, Hirose M (1984) Dose-response study of urinary bladder carcinogenesis in rats by N-butyl-N-(4-hydroxybutyl)-nitrosamine J Cancer Res Clin Onco 1108: 169–173Google Scholar
  52. Jacobs JB, Arai M, Cohen SM, Friedell GH (1976) Early lesions in experimental bladder cancer: scanning electron microscopy of cell surface markers. Cancer Res 36: 2512–2517PubMedGoogle Scholar
  53. Jacobs JB, Arai M, Cohen SM, Friedell GH (1977) A longterm study of reversible and progressive urinary bladder cancer lesions in rats fed N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. Cancer Res 37: 2817–2821PubMedGoogle Scholar
  54. Johansson S (1978) Urothelial hyperplasia of the urinary bladder of the rat induced by mechanical perforation and phenacetin treatment. Acta Patho Microbiol Immunol Scand [A] 86: 333–335Google Scholar
  55. Johansson S (1981) Carcinogenicity of analgesics: longterm treatment of Sprague-Dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen). Intl Cancer 27: 521–529CrossRefGoogle Scholar
  56. Johansson S, Angervall L (1976) Urothelial changes of the renal papillae in Sprague-Dawley rats induced by long term feeding of phenacetin. Acta Pathol Microbiol Immunol Scand [A] 84: 375–383Google Scholar
  57. Ju II JW (1975) Carcinogenesis by chemical implanted into the bladder: an evaluation. Gann Monograph Cancer Res 17: 383–392Google Scholar
  58. Koo CH, Pauli B, Friedell GH, Weinstein RS (1979) Induction of proliferative activity in urinary bladder epithelium by cystoscopy fluids. Lab Invest 40: 265Google Scholar
  59. Koss LG (1977) Some ultrastructural aspects of experimental and human carcinoma of the bladder. Cancer Res 37: 2824–2835PubMedGoogle Scholar
  60. Koss LG, Lavin P (1970) Effects of a single dose of cyclophosphamide on various organs in the rat. II. Response of urinary bladder epithelium according to strain and sex. JNCI 44: 1195–1200Google Scholar
  61. Kunze E (1979) Development of urinary bladder cancer in the rat. Curr Top Pathol 67: 145–232PubMedCrossRefGoogle Scholar
  62. Kunze E, Gassner G (1986) Modification of N-methyl-Nnitrosourea-induced urinary bladder carcinogenesis in rats following stimulation of urothelial proliferation by a partial cystectomy. J Cancer Res Clin Oncol (to be published)Google Scholar
  63. Kunze E, Schauer A, Calvoer R (1969) Zur Histochemie von Harnblasenpapillomen der Ratte, induziert durch Dibutylnitrosamin. Naturwissenschaften 56: 639PubMedCrossRefGoogle Scholar
  64. Kunze E, Möhlmann R (1983) Proliferation-stimulating effect of phenacetin on the urothelium and papillary epithelium of rats. Urol Int 38: 223–228PubMedCrossRefGoogle Scholar
  65. Kunze E, Pacha H (1985) Modifikation der Urothelkarzinogenese durch Proliferationstimulation. In: Harzmann R, Jacobi G, Weissbach L (eds) Experimentelle Urologie. Springer, Berlin Heidelberg New York Tokyo, pp 414–429Google Scholar
  66. Kunze E, Schauer A (1971) Enzymhistochemische und autoradiographische Untersuchungen an Dibutylnitrosamine-induzierten Harnblasenpapillomen der Ratte. Z Krebsforsch 75: 146–160PubMedCrossRefGoogle Scholar
  67. Kunze E, Schauer A (1977) Morphology, classification and histogenesis of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced carcinomas in the urinary bladder of rats. Z Krebsforsch 88: 273–289CrossRefGoogle Scholar
  68. Kunze E, Schauer A, Spielmann J (1971) Autoradiographische Untersuchungen über den RWS-Stoffwechsel während der Entwicklung von Dibutylnitrosamine-induzierten Harnblasentumoren der Ratte. Z Krebsforsch 76: 236–248CrossRefGoogle Scholar
  69. Kunze E, Schauer A, Krüsmann G (1975) Focal loss of alkaline phosphatase and increase of proliferation in preneoplastic areas of the rat urothelium after administration of N-butyl-N-(4-hydroxybutyl)-nitrosamine and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide. Z Krebsforsch 84: 143–160CrossRefGoogle Scholar
  70. Kunze E, Schauer A, Schatt S (1976) Stages of transformation in the development of N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced transitional cell carcinomas in the urinary bladder of rats. Z Krebsforsch 87: 139–160CrossRefGoogle Scholar
  71. Kunze E, Albrecht H, Wöltjen HH, Schauer A (1979) Die repartive Regeneration des Rattenurothels nach partieller Cystektomie und ihre Bedeutung für die Carcinogenes. J Cancer Res Clin Onco 195: 159–175CrossRefGoogle Scholar
  72. Kunze E, Engelhardt W, Steinroder H, Wöltjen HH, SchauerA (1980) Proliferationskinetik regenerierender Urothelzellen in der Rattenharnblase nach Applikation von Cyclophosphamid. Virchows Arch [Cell Path] 33: 47–66Google Scholar
  73. Kunze E, Wöltjen HH, Albrecht H (1983a) Absence of a complete carcinogenic effect of phenacetin on the quiescent and proliferating urothelium stimulated by partial cystectomy. Urol Int 38: 95–103PubMedCrossRefGoogle Scholar
  74. Kunze E, Wöltjen HH, Hartmann B, Engelhardt W (1983 b) Animal experiments regarding a possible carcinogenic effect of phenacetin on the resting and proliferating urothelium stimulated by cyclophosphamide. J Cancer Res Clin Onco 1105: 38–47CrossRefGoogle Scholar
  75. Kunze E, Köhnecke B, Engelhardt W, Steinröder H, Brock N, Pohl J (1984) Effect of the uroprotector sodium 2-mercaptoethane sulfonate (Mesna) on the proliferation of the bladder urothelium in the rat after administration of cyclophosphamide. Urol Int, 39: 61–67PubMedCrossRefGoogle Scholar
  76. Lessel B (1970) Carcinogenic teratogenic aspects of saccharin. Proceedings of the 3rd international congress of food science and technology, pp 764–770Google Scholar
  77. Locher GW, Cooper EH (1970) Repair of rat urinary bladder epithelium following injury by cyclophosphamide. Invest Urol 8: 116–123PubMedGoogle Scholar
  78. Macklin AW, Szot RJ (1980) Eighteen month oral study of aspirin, phenacetin and caffeine in C57BL/6 mice. Drug Chem Toxicol 3: 135–163PubMedCrossRefGoogle Scholar
  79. Mobley TL, Coyle JK, Al-Hussaini M, McDonald DF (1966) The role of chronic mechanical irritation in experimental urothelial tumorigenesis. Invest Urol 3: 325–333PubMedGoogle Scholar
  80. Munro JC, Moodie CA, Krewsland D, Grice HC (1975) A carcinogenicity study of commercial saccharin in the rat. Toxicol Appl Pharmacol 32: 513–526PubMedCrossRefGoogle Scholar
  81. Murasaki G, Cohen SM (1981) Effect of dose of sodium saccharain on the induction of rat urinary bladder proliferation. Cancer Res 41: 942–944PubMedGoogle Scholar
  82. Murasaki G, Cohen SM (1983) Effect of sodium saccharin on urinary bladder epithelial regenerative hyperplasia following freeze ulceration. Cancer Res 43: 182–187PubMedGoogle Scholar
  83. Murphy WM, Soloway MS, Crabtree WN (1981) The morphologic effects of mitomycin C in mammalian urinary bladder. Cancer 47: 2567–2574PubMedCrossRefGoogle Scholar
  84. Nakanishi K, Fukushima S, Shibata M, Shirai T, Ogiso T, Ho N (1978) Effect of phenacetin and caffeine on the urinary bladder of rats treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine. Gann 69: 395–400PubMedGoogle Scholar
  85. Nakanishi K, Hirose M, Ogiso T, Hasegawa R, Arai M, Ho N (1980a) Effects of sodium saccharin and caffeine on the urinary bladder of rats treated with N-butyl-N(4-hydroxybutyl)-nitrosamine. Gann 71: 490–500PubMedGoogle Scholar
  86. Nakanishi K, Hagiwara A, Shibata M, Imaida K, Tatematsu M, Ho N (1980b) Dose response of saccharin in induction of urinary bladder hyperplasias in Fischer 344 rats pretreated with N-butyl- N-(4-hydroxybutyl)nitrosamine. JNCI 65: 1005–1010PubMedGoogle Scholar
  87. Okajima E, Hiramatsu T, Motmiga Y, Kondo T, Hirao Y (1973) Effects of foreign bodies on development of urinary bladder tumors in rats treated with N-butyl-N(4-hydroxybutyl)-nitrosamine. Urol Res 1: 177–181PubMedCrossRefGoogle Scholar
  88. Oser BL, Carson S, Cox GE, Vogin EE, Sternberg SS (1975) Chronic toxicity study of cyclamate: saccharin (10:1) in rats. Toxicology 4: 315–330PubMedCrossRefGoogle Scholar
  89. Oyasu R, Miller DA, McDonald JH, Hass GM (1963) Neoplasms of rat urinary bladder and liver. Arch Pathol 75: 184–190PubMedGoogle Scholar
  90. Price JM, Biava CG, Oser BL, Vogin EE, Steinfeld J, Ley HL (1970) Bladder tumors in rats fed cyclohexylamine or high doses of a mixture of cyclamate and saccharin. Science 167: 1131–1132PubMedCrossRefGoogle Scholar
  91. Radomski JL, Brill E, Glass EM (1967) Induction of bladder tumors and other malignancies in rats with 2-methoxy-3-amino-dibenzofuran. JNCI 39: 1069–1080Google Scholar
  92. Reese DH, Friedmann RD, Smith JM, Sporn MB (1976) Organ culture of normal and carcinogen-treated rat bladder. Cancer Res 35: 2525–2527Google Scholar
  93. Roe FJC (1964) An illustrated classification of the proliferative and neoplastic changes in mouse bladder epithelium in response to prolonged irritation. Br J Urol 36: 238–253PubMedCrossRefGoogle Scholar
  94. Rübben H, Hautmann R, Dahm HH (1983) Tierexperimentelle Grundlagen der intravesikalen Chemorezidivprophylaxe. I3eitr Urol 3: 47–58Google Scholar
  95. Santana S (1963) The use of rat bladder pouches to elucidate the mode of action of a chemical which induces hyperplasia in the bladder epithelium. Br J Cancer 17: 715–719PubMedCrossRefGoogle Scholar
  96. Schmähl D (1973) Fehlen einer kanzerogenen Wirkung von Cyclamat, Cyclohexylamin and Saccharin bei Ratten. Arzneimittelforsch 23: 1466–1470PubMedGoogle Scholar
  97. Schmähl D (1978) Experiments on the carcinogenic effect of ortho-toluol-sulfonamide (OTS). Z Krebsforsch 91: 19–22CrossRefGoogle Scholar
  98. Sen GKP (1962) Hyperplasia of urinary tract epithelium induced by continuous administration of sulphonamide derivatives. Br J Cancer 16: 110–119CrossRefGoogle Scholar
  99. Severs NJ, Barnes SH, Wright R, Hicks RM (1982) Induction of bladder cancer in rats by fractionated intravesicular doses of N-methyl-N-nitrosourea. Br J Cancer 45: 337–351PubMedCrossRefGoogle Scholar
  100. Shirai T, Murasaki G, Tatematsu M, Tsuda H, Fukushima S, Ito N (1977) Early surface changes of the urinary bladder epithelium of different animal species induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine. Gann 68: 203–312PubMedGoogle Scholar
  101. Shirai T, Cohen SM, Fukushima S, Hananouchi M, Ito N (1978) Reversible papillary hyperplasia of the rat urinary bladder. Am J Pathol 91: 33–48PubMedGoogle Scholar
  102. Stashey J, Paschkis KE, Cantarow A, Rothenberg MS (1947) Neoplasms in rats with 2-acetaminfluorene and sex hormones II. Cancer Res 7: 356–362Google Scholar
  103. Stiller D, Rauscher H (1971) Irreversible preneoplastic defect in alkaline phosphatase in cancerization of transitional epithelium. Exp Pathol 5: 255–258Google Scholar
  104. Strömbeck JP, Ekmann B (1949) Effect of 2-acetaminofluorene ( AAF) in inducing tumours of the bladder. Acta Pathol Microbiol Immunol Scand (A) 26: 480–495CrossRefGoogle Scholar
  105. Tatematsu M, Cohen SM, Fukushima S, Shirai T, Shinohara Y, Ito N (1978) Neovascularization in benign and malignant urinary bladder epithelial proliferative lesions of the rat observed in situ by scanning electron microscopy and autoradiography. Cancer Res 38: 1792–1800PubMedGoogle Scholar
  106. Tatematsu M, Imaida K, Fukushima S, Arai M, Mizutani M, Ito N (1981) Cytopathological effect of partial cystectomy of rats. Acta Pathol Jpn 31: 535–543PubMedGoogle Scholar
  107. Thiele J, Adolphs HD, Reale E (1979) Membrane transformation in malignancy: the normal and neoplastic transitional epithelium of the rat urinary bladder. J Submicrosc Cyto 111: 249–261Google Scholar
  108. Tiltmann AJ, Friedell GH (1971) The histogenesis of experimental bladder cancer. Invest Urol 9: 218–226Google Scholar
  109. Toyoshima K, Leighton J (1975) Bladder calculi and urothelial hyperplasia with papillomatosis in the rat following insertion of chalk powder in the bladder cavity with subsequent trauma of the bladder wall. Cancer Res 35: 3786–3791PubMedGoogle Scholar
  110. Tudor RJ, Severs NJ, Hicks RM (1983) The induction of urothelial hyperplasia by methyl methanesulphonate and ethyl methanesulphonate. Br J Cancer 48: 289–300PubMedCrossRefGoogle Scholar
  111. Tudor RI, Severs NJ, Hicks RM (1984) The `promoting’ activity of methyl methanesulphonate in rat bladder carcinogenesis. Br J Cancer 50: 63–75PubMedCrossRefGoogle Scholar
  112. Wakefield JSJ, Hicks RM (1974) Erythrophagocytosis by the epithelial cells of the bladder. J Cell Sci 15: 555–573PubMedGoogle Scholar
  113. Weil CS, Carpenter CP, Smyth HF Jr (1965) Urinary bladder response to diethylene glycol. Arch Environ Health 11: 569–581PubMedGoogle Scholar
  114. Weil CS, Carpenter CP, Smyth HF Jr (1967) Urinary bladder calculus and tumor response following either repeated feeding of diethylene glycol or calcium oxalate stone implantation. Industr Med Surg: 36: 55–57Google Scholar
  115. Wilson RH, De Eds F, Cox AJ (1941) The toxicity and carcinogenic activity of 2-acetaminofluorene. Cancer Res 1: 595–608Google Scholar
  116. Wolbach SB, Howe PR (1925) Tissue changes following deprivation of fat-soluble A vitamin. Y Exp Med 42: 753–781CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1986

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  • E. Kunze

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