Diphenylthiazole-Induced Renal Cystic Disease, Rat
Kidneys are bilaterally and symmetrically enlarged three- to fivefold (Fig. 239) after 4–8 weeks of diphenylthiazole feeding 1.03% in pelletized rat chow (Carone et al. 1974). Enlargement is most prominent in outer medulla and consists of dilated tubules arranged radially (Fig. 239). Renal microdissection reveals saccular and fusiform dilations of all collecting tubules in the outer medulla, with occasional distention of cortical collecting and distal tubules. Following drug withdrawal, gross renal changes return to normal in 4–8 weeks (Kanwar and Carone 1984).
SynonymsPolycystic kidney disease
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- Carone FA, Stolarczyk J, Krumlovsky FA, Perlman SG, Roberts TH, Rowland RG (1975) The nature of a drug-induced renal concentrating defect in rats. Lab Invest 31: 658–664Google Scholar