Urinary System pp 249-254 | Cite as

Effect of Experimental Diabetes Mellitus, Kidney, Rat

  • Herbert Wehner
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

Diabetic rat kidneys are larger than those of normal rats of corresponding age. The capsular surface is usually smooth. A fine granulation can occur in late stages. The cut surfaces are brownish red.

Synonyms

Diabetic glomerulosclerosis diabetic nephropathy 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bell RH Jr, Borjesson BA, Wolf PL, Fernandez-Cruz L, Brimm JE, Lee S, Sayers HJ, Orloff MJ (1984) Quantitative morphological studies of aging changes in the kidney of the Lewis rat. Renal Physiol 7: 176–184PubMedGoogle Scholar
  2. Cohen MP, Klein CV (1979) Glomerulopathy in rats with streptozotocin diabetes. Accumulation of glomerular basement membrane analogous to human diabetic nephropathy. J Exp Med 149: 623–631PubMedCrossRefGoogle Scholar
  3. Haley DP, Bulger RE (1983) The aging male rat: structure and function of the kidney. Am J Anat 167: 1–13PubMedCrossRefGoogle Scholar
  4. Hasslacher C, Reichenbacher R, Gechter F, Timpl R (1984) Glomerular basement membrane synthesis and serum concentration of type IV collagen in streptozotocin-diabetic rats. Diabetologia 26: 150–154PubMedCrossRefGoogle Scholar
  5. Hirose K, Osterby R, Nozawa M, Gundersen HJG (1982) Development of glomerular lesions in experimental long-term diabetes in the rat. Kidney Int 21: 689–695PubMedCrossRefGoogle Scholar
  6. Hostetter TH, Troy JL, Brenner BM (1981) Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int 19: 410–415PubMedCrossRefGoogle Scholar
  7. Jensen PK, Sandahl Christiansen J, Steven K, Parving HH (1981) Renal function in streptozotocin-diabetic rats. Diabetologia 21: 409–414PubMedCrossRefGoogle Scholar
  8. Leegwater DC, Kuper CF (1984) Evaluation of histological changes in the kidneys of the alloxan diabetic rat by means of factor analysis. Food Chem Thoxicol 22: 551–557CrossRefGoogle Scholar
  9. Michels LD, O’Donnell MP, Keane WF (1984) Glomerular hemodynamic and structural correlations in longterm experimental diabetic rats. J Lab Clin Med 103: 840–847PubMedGoogle Scholar
  10. Morita T, Churg J (1983) Mesangiolysis. Kidney Int 24: 1–9CrossRefGoogle Scholar
  11. Risteli J, Draeger KE, Regitz G, Neubauer HP (1982) Increase in circulating basement membrane antigens in diabetic rats and effects of insulin treatment. Diabetologia 23: 266–269PubMedCrossRefGoogle Scholar
  12. Steffes MW, Mauer SM (1984) Diabetic glomerulopathy in man and experimental animal models. Int Rev Exp Pathol 26: 147–175PubMedGoogle Scholar
  13. Steffes MW, Vernier RL, Brown DM, Basgen JM, Mauer SM (1982) Diabetic glomerulopathy in the uninephrectomized rat resists amelioration following islet transplantation. Diabetologia 23: 347–353PubMedCrossRefGoogle Scholar
  14. Volkmann P, Wehner H (1986) Renal vessel changes in diabetic KK-mice. Virchows Arch [A] (to be published)Google Scholar
  15. Wehner H (1977) Morphologie der diabetischen Nephropathie. Munch Med Wochenschr 119: 489–492Google Scholar
  16. Wehner H, Petri M (1983) Glomerular alterations in experimental diabetes of the rat. Pathol Res Pract 176: 145–157PubMedCrossRefGoogle Scholar
  17. Wehner H, Höhn D, Faix-Schade U, Huber H, Walzer P (1972) Glomerular changes in mice with spontaneous hereditary diabetes. Lab Invest 27: 331–340PubMedGoogle Scholar
  18. Wehner H, Kösters W, Strauch M, Staudenmeier M (1980) Effect of islet transplantation on the glomerular changes in streptozotocin-diabetic rats. Virchows Arch (A) 88: 137–154Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Herbert Wehner

There are no affiliations available

Personalised recommendations