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Urinary System pp 192-210 | Cite as

Glomerulonephritis, Mouse

  • Bernard Sass
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

The kidneys of mice with glomerulonephritis vary in appearance depending on the stage of the dis- ease, but both kidneys are usually equally affect ed. In strain NZB and in (NZB × NZW) F1 hybrids in the acute phase of systemic lupus, the kidneys are café au lait or dusky pink and enlarged; the surfaces are smooth and shiny, and the capsule is nonadherent. Later in the course of the disease, the kidneys may be shrunken and the capsule adherent, revealing a granular pitted surface and small cysts or petechiae on the cut surface.

Synonyms

Glomerulopathy glomerulosclerosis hyalinization of glomeruli 

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  • Bernard Sass

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