Urinary System pp 192-210 | Cite as

Glomerulonephritis, Mouse

  • Bernard Sass
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The kidneys of mice with glomerulonephritis vary in appearance depending on the stage of the dis- ease, but both kidneys are usually equally affect ed. In strain NZB and in (NZB × NZW) F1 hybrids in the acute phase of systemic lupus, the kidneys are café au lait or dusky pink and enlarged; the surfaces are smooth and shiny, and the capsule is nonadherent. Later in the course of the disease, the kidneys may be shrunken and the capsule adherent, revealing a granular pitted surface and small cysts or petechiae on the cut surface.


Glomerulopathy glomerulosclerosis hyalinization of glomeruli 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abe C, Chia D, Barnett EV, Pearson CM, Shiokawa Y (1977) Effects of water soluble adjuvant (WSA) on New Zealand (NZB x NZW)F1 hybrid mice. Clin Immunol Immunopathol 8: 17–27PubMedGoogle Scholar
  2. Abramowsky CR, Powers KG, Aikawa M, Swinehart G (1981) Dirofilaria immitis. Immunopathology of filarial nephropathy in dogs. Am J Pathol 104: 1–12PubMedGoogle Scholar
  3. Anderson LJ, Jarrett WFH (1971) Membranous glomerulonephritis associated with leukemia in cats. Res Vet Sci 12: 179–180.PubMedGoogle Scholar
  4. Andrews BS, Eisenberg RA, Theofilopoulos AN, Izui S, Wilson CB, McConahey PJ, Murphy ED, Roths JB, Dixon FJ (1978) Spontaneous mutine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med 148: 1198–1215PubMedGoogle Scholar
  5. Angus KW, Gardiner AC, Mitchell B, Thompson D (1980) Mesangiocapillary glomerulonephritis in lambs. J Pathol 131: 65–74PubMedGoogle Scholar
  6. Assmann JM, Tangelder MM, Lange WPJ, Tadema TM, Koene RAP (1983) Membranous glomerulonephritis in the mouse. Kidney Int 24: 303–312PubMedGoogle Scholar
  7. Banks KL, Henson JB (1972) Immunologically mediated glomerulitis of horses: II. Antiglomerular basement membrane antibody and other mechanisms in spontaneous disease. Lab Invest 26: 708–715PubMedGoogle Scholar
  8. Banks KL, Henson JB, McGuire TC (1972) Immunologically mediated glomerulitis of horses: I. Pathogenesis in persistent infection by equine infectious anemia virus. Lab Invest 26: 701–707PubMedGoogle Scholar
  9. Bielschowsky M, Helyar BJ, Howie JB (1959) Spontaneous hemolytic anemia in mice of the NZB/BL strain. Proc Univ Otago Med School 37: 9–11Google Scholar
  10. Boonpucknavig V, Boonpucknavig S, Bhamarapravati N (1979) Plasmodium berghei infected mice. Focal glomerulonephritis in hyperimmune state. Arch Pathol Lab Med 103: 567–572PubMedGoogle Scholar
  11. Borel Y, Lewis RM, Andre-Schwartz J, Stollar BD, Diener E (1978) Treatment of lupus nephritis in adult (NZB x NZW)F1 mice by cortisone-facilitated tolerance to nucleic acid antigens. J Clin Invest 61: 276–286PubMedGoogle Scholar
  12. Brown P (1968) Evolution of lymphocytic choriomeningitis virus infection from neonatal inoculation through development of adult “late onset disease” and glomerulonephritis. Archiv Ges Virusforsch 24: 220–230Google Scholar
  13. Burch GE, Chu KC, Sohal RS (1968) Glomerulonephritis induced in mice by echo 9 virus. N Engl J Med 279: 1420–1424PubMedGoogle Scholar
  14. Cavallo T, Graves K, Granholm NA (1983a) Murine lupus nephritis: effect of azathioprine on glomerular permeability and localization of immunoreactants. Clin Exp Immunol 53: 547–554PubMedGoogle Scholar
  15. Cavallo T, Graves K, Granholm NA (1983b) Mutine lupus nephritis. Effects of glucocorticoid on circulating and tissue bound immunoreactants. Lab Invest 49: 476–481PubMedGoogle Scholar
  16. Cavallo T, Goldman M, Graves K, Lambert PH (1983c) Altered glomerular permeability in the early phase of immune complex nephritis. Kidney Int 24: 632–637PubMedGoogle Scholar
  17. Cavallo T, Graves K, Granholm NA (1984) Mutine lupus nephritis: effects of cyclophosphamide on circulating and tissue bound immunoreactants. Clin Exp Immunol 55: 67–73PubMedGoogle Scholar
  18. Channing AA, Kasuga T, Horowitz RE, Dubois EL, Demopoulos HB (1965) An ultrastructural study of spontaneous lupus nephritis in the NZB/BL-NZW mouse. Am J Pathol 47: 677–694PubMedGoogle Scholar
  19. Cheville NF (1983) Immunopathology. In: Cell pathology, 2nd edn. Iowa State University, Press, Ames, chaps 7, 13Google Scholar
  20. Chia D, Levy L, Barnett EV, Carnes WH (1981) Effects of pulse cyclophosphamide on NZB/W disease. Immunology 57: 43–65Google Scholar
  21. Comerford FR, Cohen AS, Desai RG (1968) The evolution of the glomerular lesion in NZB mice–a light and electron microscopic study. Lab Invest 19: 643–651PubMedGoogle Scholar
  22. Croker BP Jr, Del Villano BC, Jensen FC, Lerner RA, Dixon FJ (1974) Immunopathogenicity and oncogenicity of mutine leukemia viruses: I. Induction of immunologic disease and lymphoma in (BALB/c x NZB)F1 mice by Scripps leukemia virus. J Exp Med 140: 1028–1048PubMedGoogle Scholar
  23. Cutlip RC, McClurkin AW, Coria MF (1980) Lesions in clinically healthy cattle persistently infected with the virus of bovine viral diarrhea-glomerulonephritis and encephalitis. Am J Vet Res 41: 1938–1941PubMedGoogle Scholar
  24. Devey ME, Bleasdale K, Stanley C, Steward MW (1984) Failure of affinity maturation leads to increased susceptibility to immune complex glomerulonephritis. Immunology 52: 377–383PubMedGoogle Scholar
  25. Dixon FJ (1979a) Immunopathogenesis of glomerulonephritis. Nippon Jinzo Gakkai Shi 21: 337–348PubMedGoogle Scholar
  26. Dixon FJ (1979b) The pathogenesis of murine systemic lupus erythematosus. Am J Pathol 97: 10–16PubMedGoogle Scholar
  27. Dixon FJ, Wilson CB, Marquardt H (1971) Experimental immunlogic glomerulonephritis. Adv Nephrol 1: 1–10Google Scholar
  28. Dubois EL, Horowitz RE, Demopoulos HB, Teplitz R (1966) NZB/NZW mice as a model of systemic lupus erythematosus. JAMA 195: 285–289PubMedGoogle Scholar
  29. Dunn TB, Larsen CD (1946) Hyalinization of glomeruli produced in strain A mice by the administration of urethane. Fed Proc 5: 220PubMedGoogle Scholar
  30. Dunn TB, Malmgren RA, Carney PG, Green AW (1966) Propylthiouracil and transfusion modifications of the effects of the Rauscher virus in BALB/c mice. JNCI 36: 1003–1025PubMedGoogle Scholar
  31. Duvic M, Steinberg AD, Klassen LW (1978) Effect of the antiestrogen Nafoxidine on NZB/W autoimmune disease. Arthritis Rheum 21: 414–417PubMedGoogle Scholar
  32. Edgington TS, Glassock RJ, Dixon FJ (1967) Autologous immune-complex pathogenesis of experimental allergic glomerulonephritis. Science 155: 1432–1434PubMedGoogle Scholar
  33. Fernandes G, Friend P, Yunis EJ, Good RA (1978) Influence of dietary restriction on immunologic function and renal disease in (NZB x NZW)F1 mice. Proc Natl Acad Sci USA 75: 1500–1504PubMedGoogle Scholar
  34. Fournié GJ, Gayral-Ta Minh M, Haas S, Pourrat JP, Conte JJ (1979) Sequential study of CL-binding substances and of anti-DNA antibodies in (NZB x NZW)F1 mice: evidence for an acute phase of the lupus disease in 2-month-old mice. Eur J Immunol 9: 652–654PubMedGoogle Scholar
  35. Fournié GJ, Gayral-Ta Minh M, Mignon-Conte MA, Haas S, Lambert PH, Conte JJ (1980a) Acceleration of glomerulonephritis in NZB x NZW mice by early immunization with DNA and injection of bacterial lipopolysaccharide. J Clin Lab Immunol 4: 103–106PubMedGoogle Scholar
  36. Fournié GJ, Mignon-Conte MA, Lule J, Gayral-Ta Minh M, Haas S, Bauriaud R, Conte JJ (1980b) Immune complex glomerulonephritis in mice infected with Escherichia coli. Clin Exp Immunol 42: 77–85PubMedGoogle Scholar
  37. Fournié GJ, Lule J, Gayral-Ta MM, Mignon-Conte M, Conte JJ, Belon B, Druet E, Hirsh F, Sapin C, Druet P, Izui S, Lambert PH (1983) Immunological pathogenesis of experimental glomerulonephritis induced by some infectious and toxic agents. Contrib Microbiol Immunol 7: 43–51PubMedGoogle Scholar
  38. Friend PS, Fernandes G, Good RA, Michael AF, Yunis EJ (1978) Dietary restrictions: early and late effects on the nephropathy of the NZB x NZW mouse. Lab Invest 38: 629–632PubMedGoogle Scholar
  39. Gallo GR, Caulin-Glaser T, Emancipator SN, Lamm ME (1983) Nephritogenicity and differential distribution of glomerular immune complexes related to immunogen charge. Lab Invest 48: 353–362PubMedGoogle Scholar
  40. Gardner MB, Ihle JN, Pillarisetty RJ, Talal N (1977) Type C virus expression and host response in diet-cured NZB/W mice. Nature 268: 341–343PubMedGoogle Scholar
  41. Germouth FG Jr, Rodriguez E, Lorelle CA, Trump EI, Milano L, Wise O’L (1979a) Passive immune complex glomerulonephritis in mice: models for various lesions found in human disease: I. High avidity complexes and xrtesangiopathic glomerulonephritis. Lab Invest 41: 360–365Google Scholar
  42. Germouth FG Jr, Rodriguez E, Lorelle CA, Trump EI, Milano LL, Wise OL (1979b) Passive immune complex glomerulonephritis in mice. Models for various lesions found in human disease: II. Low avidity complexes and diffuse proliferative glomerulonephritis with subepithelial deposit. Lab Invest 41: 366–371Google Scholar
  43. Glick AD, Horn RG, Holscher M (1978) Characterization of feline glomerulonephritis associated with viral induced hematopoietic neoplasms. Am J Pathol 92: 321–332PubMedGoogle Scholar
  44. Gresser I, Maury C, Tovey M, Morel-Maroger L, Pontillon F (1976) Progressive glomerulonephritis in mice treated with interferon preparations at birth. Nature 263: 420–422PubMedGoogle Scholar
  45. Hahn BH, Ebling FM (1983) Suppression of NZB/NZW murine nephritis by administration of a syngeneic monoclonal antibody to DNA. Possible role of anti-idiotypic antibodies. J Clin Invest 71: 1728–1736PubMedGoogle Scholar
  46. Hahn BH, Ebling FM (1984) Suppression of mutine lupus nephritis by administration of an anti-idiotypic antibody to anti-DNA. J Immunol 132: 187–190PubMedGoogle Scholar
  47. Hahn BH, Knotts LL (1979) Alteration of lymphocyte function in NZB/NZW mice: IV. Response to levamisole. Arthritis Rheum 22: 236–242PubMedGoogle Scholar
  48. Henson JB, Gorham JR, Tanaka Y, Padgett GA (1968) The sequential development of ultrastructural lesions in the glomeruli of mink with experimental Aleutian disease. Lab Invest 19: 153–162Google Scholar
  49. Heymann W, Hackel DB, Harwood S, Wilson SGF, Hunter JLP (1959) Production of nephrotic syndrome in rats by Freund’s adjuvant and rat kidney suspensions. Proc Soc Exper Biol Med 100: 660–664Google Scholar
  50. Hicks JD, Burnet FM (1966) Renal lesions in the “autoimmune” mouse strains NZB and F1 NZB x NZW. J Pathol Bacteriol 91: 467–476PubMedGoogle Scholar
  51. Hoffsten PE, Hill CL, Klahr S (1975) Studies of albuminuria and proteinuria in normal mice and mice with immune complex glomerulonephritis. J Lab Clin Med 86: 920–930PubMedGoogle Scholar
  52. Hoffsten PE, Hill C, Shreffler DC (1976) Glomerular deposition of Ss protein in murine immune complex glomerulonephritis. Clin Immunol Immunopathol 6: 47–50Google Scholar
  53. Hoffsten PE, Villalobos R, Hill C, Klahr S (1977) T-cell deficiency in immune complex glomerulonephritis. Kidney Int 11: 318–326PubMedGoogle Scholar
  54. Hoffsten PE, Swerdlin A, Bartell M, Hill CL, Venverloh J, Brotherson K, Klahr S (1979) Reticuloendothelial and mesangial function in murine immune complex glomerulonephritis. Kidney Int 15: 144–159PubMedGoogle Scholar
  55. Howie JB, Helyer BJ (1965) Autoimmune disease in mice. Ann NY Acad Sci 124: 167–177PubMedGoogle Scholar
  56. Howie JB, Helyer BJ (1966) The influence of neonatal thymectomy and thymus grafting on spontaneous autoimmune diseases in mice. In: Wolstenholme GEW, Porter R (eds) CIBA Foundation Symposium–The thymus: experimental and clinical studies. Little Brown, Boston, pp 360–380Google Scholar
  57. Howie JB, Helyer BJ (1968) The immunology and pathology of NZB mice. Adv Immunol 9: 215–267PubMedGoogle Scholar
  58. Humair L, Potter EV, Kwaan HC (1969) The role of fibrinogen in renal disease: I. Production of experimental lesions in mice. J Lab Clin Med 74: 60–71PubMedGoogle Scholar
  59. Hunt JS, McGiven AR, Day WA (1976) Immune complex glomerular disease in argyric mice. Pathology 8: 205–210PubMedGoogle Scholar
  60. Hunt JS, McGiven AR, Jackson AE, Day WA (1980) Macrophages in NZB/NZW mouse glomerular disease. Renal Physiol 3: 368–374PubMedGoogle Scholar
  61. Hurd ER, Gilliam JN, Ziff M (1976) The differential effects of cyclophosphamide and 6-mercaptopurine on the renal disease and skin immunoglobulin deposits of NZB-NZW F1 hybrid mice. Agents Actions 6: 364–368PubMedGoogle Scholar
  62. Hurd ER, Johnston JM, Okita JR, MacDonald PC, Ziff M, Gilliam JM (1981) Prevention of glomerulonephritis and prolonged survival in New Zealand White F1 hybrid mice fed an essential fatty acid-deficient diet. J Clin Invest 67: 476–485PubMedGoogle Scholar
  63. Imamura M, Mellors RC, Strand M, August JT (1977) Murine type c viral envelope glycoprotein gp 69/71 and lupus-like glomerulonephritis of New Zealand mice. Am J Pathol 86: 375–380PubMedGoogle Scholar
  64. Isaacs KL, Miller F (1983) Antigen size and charge in immune complex glomerulonephritis. II Passive induction of immune deposits with dextran - anti dextran immune complexes. Am J Pathol 111: 298–306PubMedGoogle Scholar
  65. Iskandar SS, Jennette JC (1983a) Interaction of antigen load and antibody response in determining heterologous protein nephritogenicity in inbred mice. Lab Invest 48: 726–734PubMedGoogle Scholar
  66. Iskandar SS, Jennette JC (1983b) Influence of antibody avidity on glomerular immune complex localization. Am J Pathol 112: 155–159PubMedGoogle Scholar
  67. Izui S, Hara I, Hang LM, Elder JH, McConahey PJ, Dixon FJ (1984) Association of elevated serum glycoprotein gp 70 with increased gp 70 immune complex formation and accelerated lupus nephritis in autoimmune male BXSB mice. Clin Exp Immunol 56: 272–280PubMedGoogle Scholar
  68. Kelley VE, Izui S (1983) Enriched lipid diet accelerates lupus nephritis in NZB x W mice. Am J Pathol 111: 288–297PubMedGoogle Scholar
  69. Kelley VE, Winklestein A (1980) Effect of prostaglandin E1 treatment on murine acute immune complex glomerulonephritis. Clin Immunol Immunopathol 16: 316–323PubMedGoogle Scholar
  70. Kirschbaum A, Bell ET, Gordon J (1949) Spontaneous and induced glomerulonephritis in an inbred strain of mice. J Lab Clin Med 34: 209–220PubMedGoogle Scholar
  71. Kolaja GJ, Fast PE (1982) Renal lesions in MRL mice. Vet Pathol 19: 663–668PubMedGoogle Scholar
  72. Kotzin BL, Strober S (1979) Reversal of NZB/NZW disease with total lymphoid irradiation. J Exp Med 150: 371–378PubMedGoogle Scholar
  73. Kubes L (1977) Experimental immune complex glomerulonephritis in the mouse with two types of immune complexes. Virchows Arch [Cell Path] 24: 343–354Google Scholar
  74. Kurtz JM, Russell SW, Lee JC, Slauson DO, Schechter RD (1972) Naturally occurring canine glomerulonephritis. Am J Pathol 67: 471–481PubMedGoogle Scholar
  75. Kusuyama Y, Nishihara T, Gen E, Saito K (1983) Effect of cyclophosphamide on murine nephrotoxic nephritis. Nephron 33: 220–223PubMedGoogle Scholar
  76. Kyogoku M, Kawashima M, Nose M, Yaginuma N, Nagao K (1981) Pathological studies on the kidney of systemic arteritis: II. Animal model: comparative studies on the pathogenesis of arteritis and glomerulonephritis of SL/Ni and MRL/1. Nippon Jinyo Gakkai Shi 23: 913–920Google Scholar
  77. Lambert PH, Dixon FJ (1968) Pathogenesis of glomerulonephritis of NZB/W mice. J Exp Med 127: 507–522PubMedGoogle Scholar
  78. Lambert PH, Goldman M, Rose LM, Morel PA (1982) A possible role for idiotypic interactions in the pathogenesis of immune complex glomerulonephritis. Transplant Proc 14: 543–546PubMedGoogle Scholar
  79. Larson CH (1976) Murine cytomegalovirus glomerulonephritis: clinical and ultrastructural observations. Am J Vet Res 37: 823–830PubMedGoogle Scholar
  80. Lehman DH, Wilson CB, Dixon FJ (1976) Increased survival times of New Zealand hybrid mice immunosuppressed by graft-versus-host reactions. Clin Exp Immunol 25: 297–302PubMedGoogle Scholar
  81. Lew AM, Steward MW (1984) Glomerulonephritis: the use of grafted hybridomas to investigate the role of epitope density, antibody affinity and antibody isotype in active serum sickness. Immunology 52: 367–376PubMedGoogle Scholar
  82. Lewis RM, Schwartz R, Henry WB Jr (1965) Canine systemic lupus erythematosus. Blood 25: 143–160PubMedGoogle Scholar
  83. Lewis RM, Smith CA, Kilham L, Borel Y (1979) Sex differences in the maintenance of immunologic tolerance to endogenous nucleic acid antigens and the prevention of murine lupus nephritis. Clin Immunol Immunopatho1 13: 92–102Google Scholar
  84. Lindemann W (1900) Sur le mode d’action de certains poisons rénaux. Ann Inst Pasteur 14: 49–59Google Scholar
  85. Lussier G (1976) Glomerulonephritis caused by murine cytomegalovirus. Vet Pathol 13: 123–130PubMedGoogle Scholar
  86. Markham RV Jr, Sutherland JC, Mardiney MR Jr (1973) The ubiquitous occurrence of immune complex localization in the renal glomeruli of normal mice. Lab Invest 29: 111–120PubMedGoogle Scholar
  87. McCluskey RT (1970) Evidence for immunologic mechanisms in several forms of human glomerular diseases. Bull NY Acad Med 46: 769–788Google Scholar
  88. McLeish KR, Gohara AF, Gunning WT III (1982a) Chronic serum sickness in the mouse. Relationship of antigen dose to glomerular pathology. Nephron 31: 82–88PubMedGoogle Scholar
  89. McLeish KR, Gohara AF, Gunning WT III (1982b) Suppression of antibody synthesis by prostaglandin E as a mechanism for preventing murine immune complex glomerulonephritis. Lab Invest 47: 147–152Google Scholar
  90. McLeish KR, Gohara AF, Johnson U, Sustarsic DL (1982c) Alteration in immune complex glomerulonephritis by arachidonic acid. Prostaglandins 23: 383–389PubMedGoogle Scholar
  91. McLeish KR, Gohara AF, Stelzer GT, Wallace JH (1983) Treatment of murine immune complex glomerulonephritis with prostaglandin E2: dose-response of immune complex deposition, antibody synthesis, and glomerular damage. Clin Immunol Immunopathol 26: 18–23PubMedGoogle Scholar
  92. Mellors RC (1965) Autoimmune disease in NZB/BL mice: I. Pathology and pathogenesis of a model system of spontaneous glomerulonephritis. J Exp Med 122: 25–40PubMedGoogle Scholar
  93. Mellors RC (1966) Autoimmune and immunoproliferative diseases of NZB/BL mice and hybrids. Int Rev Exp Pathol 5: 217–252PubMedGoogle Scholar
  94. Morel-Maroger L (1982) Glomerular lesions induced by interferon. Transplant Proc 14: 499–505PubMedGoogle Scholar
  95. Morel-Maroger L, Sloper JC, Vinter MI, Biol MI, Woodrow D, Gresser I (1978) An ultrastructural study of the development of nephritis in mice treated with interferon in the neonatal period. Lab Invest 39: 513–522PubMedGoogle Scholar
  96. Morgan AG, Steward MW (1976) Macrophage clearance function and immune complex disease in New Zealand Black/White F1 hybrid mice. Clin Exp Immunol 26: 133–136PubMedGoogle Scholar
  97. Murphy ED, Roths JB (1978a) A single gene model for massive lymphoproliferation with immune complex disease in new mouse strain MRL. In: Seno S, Takaku F, Irino S (eds) Topics in hematology. Excerpta Medica, AmsterdamGoogle Scholar
  98. Murphy ED, Roths JB (1978b) Autoimmunity and lymphoproliferation: induction by mutant gene 1pr, and acceleration by a male associated factor in strain BXSB mice. In: Rose NR, Bigazzi PE, Warner NL (eds) Genetic control of autoimmune disease. Elsevier/North Holland, New York, pp 207–219Google Scholar
  99. Murray M, Wright NG (1974) A morphologic study of canine glomerulonephritis. Lab Invest 30: 213–221Google Scholar
  100. Nakopoulou L, Papacharalampous N (1978) Glomerulonephritis in malignant extra renal neoplasms. Res Exp Med (Berl) 172: 1–6Google Scholar
  101. Natali PG, Cioli D (1976) Immune complex nephritis in Schistosoma mansoni infected mice. Eur J Immunol 6: 359–364PubMedGoogle Scholar
  102. Nishihara T, Kusuyama Y, Gen E, Tamaki N, Saito K (1981) Masugi nephritis produced by the antiserum to heterologous glomerular basement membrane: I. Results in mice. Acta Pathol Jpn 31: 85–92PubMedGoogle Scholar
  103. Okabayashi A, Kondo Y, Shigematsu H (1976) Cellular and histopathologic consequences of immunologically induced experimental glomerulonephritis. Curr Top Pathol 61: 1–43PubMedGoogle Scholar
  104. Okudaira H, Terada E, Fukuda K, Ito T, Gohda A, Nomura T, Kudo K, Ogita T, Miyamoto T (1984) Treatment of NZB/W F1 mice with NZW splenic T cells or with serum of mice experiencing the graft-versus-host reaction: suppression of ongoing anti-double-stranded (ds) DNA antibody formation and improvement of renal function. Clin Immunol Immunopathol 32: 359–367PubMedGoogle Scholar
  105. Osborne CA, Vernier RL (1973) Glomerulonephritis in the dog and cat: a comparative review. J Am Anim Hosp Assoc 9: 101–127Google Scholar
  106. Osborne CA, Stevens JB, McClean R, Vernier RL (1973) Membranous lupus glomerulonephritis in a dog. J Am Anim Hosp Assoc 9: 295–300Google Scholar
  107. Pascal RR, Koss MN, Kassel RL (1973) Glomerulonephritis associated with immune complex deposits and viral particles in spontaneous murine leukemia. Lab Invest 29: 159–165PubMedGoogle Scholar
  108. Pelletier M, Hinglais N, Bach J-F (1975) Characteristic immunohistochemical and ultrastructural glomerular lesions in nude mice. Lab Invest 32: 388–396PubMedGoogle Scholar
  109. Portis JL, Coe JE (1979) Deposition of IgA in renal glomeruli of mink affected with Aleutian disease. Am J Pathol 96: 227–236PubMedGoogle Scholar
  110. Prickett JD, Robinson DR, Steinberg AD (1981) Dietary enrichment with the polyunsaturated fatty acid eicosapentanoic acid prevents proteinuria and prolongs survival in NZB x NZW F1 mice. J Clin Invest 68: 556–559PubMedGoogle Scholar
  111. Rifai A, Small PA Jr, Teague PO, Ayoub EM (1979) Experimental nephropathy. J Exp Med 150: 1161–1173PubMedGoogle Scholar
  112. Ronco P, Verroust P, Morel-Maroger L (1982) Viruses and glomerulonephritis. Nephron 31: 97–102PubMedGoogle Scholar
  113. Ronco P, Verroust P, Morel-Maroger L (1983) Role of interferon in the genesis of experimental glomerulonephritis in mice. Contrib Microbiol Immunol 7: 73–82PubMedGoogle Scholar
  114. Rudofsky UH (1981) Murine lupus is accelerated by antiglomerular basement membrane autoantibodies. Clin Exp Immunol 44: 18–23PubMedGoogle Scholar
  115. Russell PJ, Hicks JD, Boston LE, Abbott A (1970) Failure to transfer haemolytic anemia or glomerulonephritis with cell-free material from NZB mice. Clin Exp Immunol 6: 227–239PubMedGoogle Scholar
  116. Sharard A (1967) Immunoelectrophoretic similarity between urine and serum proteins in mice (NZB x NZW)F1 with lupus nephritis and proteinuria. Proc Univ Otago Med School 45: 30–31Google Scholar
  117. Shiraki M, Fujiwara M, Tomura S (1984) Long term administration of cyclophosphamide in MRL/1 mice: I. The effects on the development of immunological abnormalities and lupus nephritis. Clin Exp Immunol 55: 333–339PubMedGoogle Scholar
  118. Sibley RK, Rosai J (1981) Urinary tract. In: Rosai J (ed) Ackerman’s surgical pathology, vol 1. Mosby, St. Louis, pp 728–849Google Scholar
  119. Simpson LO (1981) Role of glomerular basement membrane thixotropy and influence of glomerular vascular pressure in the pathogenesis of immune complex-induced glomerulonephritis. A new hypothesis. Nephron 27: 105–112PubMedGoogle Scholar
  120. Simpson LO, Aarons I, Howie JB (1979) Thiamphenicol and lupus nephritis. Effects of long term therapy on kidney function and pathology: a pilot study. Br J Exp Pathol 60: 45–57PubMedGoogle Scholar
  121. Slauson DO, Russell SW, Schechter RD (1971) Naturally occurring immune complex glomerulonephritis in the cat. J Pathol 103: 131–133PubMedGoogle Scholar
  122. Snell KC, Stewart HL (1967) Neoplastic and non-neoplastic renal disease in Praomys (Mastomys) natalensis. JNCI 39: 95–117PubMedGoogle Scholar
  123. Steblay RW (1962) Glomerulonephritis induced in sheep by injections of heterologous glomerular basement membrane and Freund’s complete adjuvant. J Exp Med 116: 253–272PubMedGoogle Scholar
  124. Steblay DO, Rudofsky U (1971) Spontaneous renal lesions and glomerular deposits of IgG and complement in guinea pigs. J Immunol 107: 1192–1196PubMedGoogle Scholar
  125. Steward MW (1979) Chronic immune complex disease in mice: the role of antibody affinity. Clin Exp Immunol 38: 414–423PubMedGoogle Scholar
  126. Stilmant MM, Couser WG, Cotran RS (1975) Experimental glomerulonephritis in the mouse associated with mesangial deposition of autologous ferritin immune complexes. Lab Invest 32: 746–756PubMedGoogle Scholar
  127. Takoda T, Grollman A (1970) Spontaneously occurring renal disease in the guinea pig. Am J Pathol 60: 103–118Google Scholar
  128. Teague PO, Yunis EJ, Rodey G, Fish AJ, Stutman O, Good RA (1970) Autoimmune phenomena and renal disease in mice. Role of thymectomy, aging, and involution of immunologic capacity. Lab Invest 22: 121–130PubMedGoogle Scholar
  129. Traub E (1975) Observations on “late onset disease” and tumor incidence in different strains of laboratory mice infected congenitally with LCM virus. Zentralbl Veterinarmed [B] 22: 764–782Google Scholar
  130. Uff JS, Mitcheson HD, Pussell BA, Brill M, Castro JE (1981) Proliferative glomerulonephritis in mice given intravenous Corynebacterium parvum. Pathology 133: 89–105Google Scholar
  131. Vernier RL, Mauer SM, Fish AJ, Michael AF (1971) The mesangial cell in glomerulonephritis. Adv Nephrol 1: 31–46Google Scholar
  132. Wehner RW, Smith RD (1983) Progressive cytomegalovirus glomerulonephritis. An experimental model. Am J Pathol 112: 313–325PubMedGoogle Scholar
  133. Wright NG, Nash AS, Thompson H, Fisher EW (1981) Membranous nephropathy in the cat and dog. A renal biopsy and follow-up study of sixteen cases. Lab Invest 45: 269–277PubMedGoogle Scholar
  134. Yoshiki T (1980) C type retrovirus gp 70 and murine lupus. In: Yoshiki T (ed) Systemic lupus erythematosus. University of Tokyo Press, Tokyo, pp 263–280Google Scholar
  135. Yoshiki T (1981) Spontaneous necrotizing arteritis and glomerulonephritis in mice. Nippon Jinzo Gakkai Shi 23: 931–938PubMedGoogle Scholar
  136. Yoshiki T, Mellors RC, Strand M, August JT (1974) The viral envelope glycoprotein of murine leukemia virus and the pathogenesis of immune complex glomerulonephritis of New Zealand mice. J Exp Med 140: 1011–1027PubMedGoogle Scholar
  137. Yoshiki T, Hayasaka T, Fukatsu R, Shirai T, Itoh T, Ikeda H, Katagiri M (1979) The structural proteins of murine leukemia virus and the pathogenesis of necrotizing arteritis and glomerulonephritis in SL/Ni mice. J Immunol 122: 1812–1820PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Bernard Sass

There are no affiliations available

Personalised recommendations