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Papillary Necrosis, Rat

  • Chapter
Urinary System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

The gross appearance of the kidney with papillary necrosis depends on several factors. Its external appearance may be normal if the lesion is of short duration. This may be true whether the lesion is incomplete or the necrotic tip has sloughed. In chronic lesions, the capsular surface may be pitted or have irregular, depressed areas and the kidney may be smaller than usual (Axelsen 1978a). In acute cases, the papilla usually appears normal or pale on the cut surface. Occasionally a sloughed papilla appearing as firm yellowish debris is present with blood in the pelvis. In chronic cases, the papilla may be seen as a hard yellow to white mass in the pelvis, leaving an irregular truncated papillary stump or an enlarged medullary cavity (Axelsen 1978a). In the homozygous Gunn rat, which is subject to spontaneous development of the lesions, the tip of the papilla develops an orange color caused by the deposition of bilirubin in that location (Axelsen 1983).

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Authors
  1. George A. Elliott
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Editors and Affiliations

  1. New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, 01772, Southborough, MA, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology, Emeritus) & Ronald Duncan Hunt D.V.M. (Professor of Comparative Pathology) (Professor of Comparative Pathology, Emeritus) &  (Professor of Comparative Pathology)

  2. Institut für Experimentelle Pathologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, 3000, Hannover 61, Federal Republic of Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

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© 1986 Springer-Verlag Berlin Heidelberg

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Elliott, G.A. (1986). Papillary Necrosis, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96956-0_17

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  • DOI: https://doi.org/10.1007/978-3-642-96956-0_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-96958-4

  • Online ISBN: 978-3-642-96956-0

  • eBook Packages: Springer Book Archive

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