Abstract
Little gross change is seen in the early stage of chronic progressive nephrosis; however, in advanced cases the weight of the kidneys may exceed by twice or more that of the mature breeder rat. The increase in size and weight of the kidneys in older laboratory rats is generally proportional to the extent of the disease. In most cases, both kidneys have a tan appearance and a granular surface marked by fine pitting and small cysts.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Berg BN (1965) Spontaneous nephrosis with proteinuria, hyperglobulinemia, and hypercholesterolemia in the rat. Proc Soc Exp Biol Med 119: 417–420
Bras G, Ross MH (1964) Kidney disease and nutrition in the rat. Toxicol Appl Pharmacol 6: 247–262
Couser WG, Stilmant MM (1975) Mesangial lesions and focal glomerular sclerosis in the aging rat. Lab Invest 33: 491–501
Gray JE (1977) Chronic progressive nephrosis in the albino rat. CRC Crit Rev Toxicol 5: 115–144
Gray JE, Weaver RN, Connor ND (1974a) Observations on the kidneys and urine of the wild Norway rat, Rattus norvegicus. Vet Pathol 11: 144–152
Gray JE, Weaver RN, Purmalis A (1974b) Ultrastructural observations of chronic progressive nephrosis in the Sprague-Dawley rat. Vet Pathol 11: 153–164
Gray JE, van Zwieten MJ, Hollander CF (1982a) Early light microscopic changes in chronic progressive nephrosis in several strains of aging laboratory rats. J Gerontol 37: 142–150
Gray JE, Larsen ER, Greenberg HS (1982b) A breeding study to control chronic progressive nephrosis in rats. Lab Anim Sci 32: 609–612
Misra RP, Kalant N (1966) Glomerular basement membrane in experimental nephrosis: chemical composition. Nephron 3: 84–102
Saxton JA Jr, Kimball GC (1941) Relation of nephrosis and other diseases of albino rats to age and to modifications of diet. Arch Pathol 32: 951–965
Simms HS, Berg BN (1957) Longevity and the onset of lesions in male rats. J Gerontol 12: 244–252
Weaver RN, Gray JE, Schultz JR (1975) Urinary proteins in Sprague-Dawley rats with chronic progressive nephrosis. Lab Anim Sci 25: 705–710
Yu BP, Masoro EJ, Murata I, Bertrand HA, Lynd FT (1982) Life span study of SPF Fischer 344 male rats fed ad libitumor restricted diets: longevity, growth, lean body mass and disease. J Gerontol 37: 130–141
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Gray, J.E. (1986). Chronic Progressive Nephrosis, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96956-0_15
Download citation
DOI: https://doi.org/10.1007/978-3-642-96956-0_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-96958-4
Online ISBN: 978-3-642-96956-0
eBook Packages: Springer Book Archive