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Abstract

Animal experimentation and research with animals is an integral part of clinical research, including surgery. The goal is to solve problems encountered in clinical practice and to develop new methods and approaches to the cure and alleviation of disease and disability. Animal experimentation is to be understood as research that will benefit both man and animals.

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References

  1. American Association of Pathologists: A workshop on needs for new animal models of human disease. Amer. J. Pathology 101, No 3S, Suppl. to December 1980.

    Google Scholar 

  2. Deutsche Forschungsgemeinschaft: Tierexperimentelle Forschung und Tierschutz Mitteilung III/ Kommission fuer Versuchstierforschung, 1981.

    Google Scholar 

  3. Gartner K, Hackbarth H, Stolte H, editors. Symposium on research animals and concepts of applicability to clinical medicine, Hannover FRG, 1981 Expl Biol Med Vol. 7, S. Karger, Basel, 1982.

    Google Scholar 

  4. Hoel DG. Animal experimentation and its relevance to man. Enviromental Health Perspectives 1980; 32: 25–30.

    Article  Google Scholar 

  5. Hoff: Immoral and moral uses of animals. New Engl J Med 1980; 302: 115–118.

    Article  PubMed  CAS  Google Scholar 

  6. IABS International 16th Congress for Biological Standardization, San Antonio/USA 1979: The standardization of animals to improve biomedical research. Basel: Production and Control S. Karger, 1980.

    Google Scholar 

  7. ILAR Symposium: The future of animals, cells, models and systems in research, development, education, and testing. Washington, D.C.: National Academy of Sciences, 1977.

    Google Scholar 

  8. Kubler K, editor. Der Tierversuch in der Arzneimittelforschung (interdisziplinaeres Fachgesprach im Bundesgesundheitsamt) BGA:-Berichte 1/1980.

    Google Scholar 

  9. McDaniel CG. Animal rights or human health? Med J Aust 1984; 855–857.

    Google Scholar 

  10. Merkenschlager M, Wilk W,: Gutachten ueber tierschutzgerechte Haltung von Versuchstieren. Gutachten ueber Tierversuche, Moeglichkeiten ihrer Einschraenkung und Ersetzbarkeit. Recommendations for the keeping of laboratory animals in accordance with animal protection principles. Parey-Berlin-Hamberg: Verlag Paul, 1979.

    Google Scholar 

  11. Riecker G. Aerztliche Ethik und Tierversuche Arzt und Krankenhaus 1984; 11: 306–312.

    Google Scholar 

  12. Sechzer JA, editor. The role of animals in biomedical research. Annals New York Academy of Sciences, 1983; 406.

    Google Scholar 

  13. Smyth HD. Alternatives to animal experimentation. Solar Press, London: 1978. Alternativen zu

    Google Scholar 

  14. Sontag KH. Der Tierversuch nach dem Stand der wissenschaftlichen Kenntnis. Pharm Ind 1982; 44: 4.

    Google Scholar 

  15. Weihe WH. Das Problem der Alternativen zum wissenschaftlichen Tierversuch. Fortschr Med 1982; 100: 2162–2166.

    PubMed  CAS  Google Scholar 

  16. Rowan AN. The concept of the three R’s, an introduction 16th IABS congress: the standardization of animals to improve biomedical research, production and control. San Antonio/USA 1979 Develop Biol Standard, Vol. 45, Karger S, Basel 1980; 175–180.

    Google Scholar 

  17. Russell, WMS, Burch RL. The principle of humane experimental technique. Methuen U. Co, London: 1959.

    Google Scholar 

  18. Stiller H, Stiller M. Tierversuch und Tierexperimentator. F. Hirthammer Verlag, Muchen: 1977.

    Google Scholar 

  19. Kirsch U. Untersuchungen zum Eintritt der Totenstarre an ischamischen Meerschweinchenherzen in Normothermie Arzneim Forschung (Drug Research) 1970; 20: 1071–1074.

    CAS  Google Scholar 

  20. Carrentier S, Murawsky M, Carpentier A. Cytotoxicity of cardioplegic solutions: evaluation by tissue culture. Circulation 1981;64:(suppl. II),II:90-II 95.

    Google Scholar 

  21. Isselhard W, Schorn B, Huegel W, Uekermann U. Comparison of three methods of myocardial protection. Thorac Cardiovasc Surg 1963; 28: 329–126.

    Article  Google Scholar 

  22. Huegel W, Lubbing H, Isselhard W, et al. Hemodynamics and metabolic status of the human heart after application of different forms of cardioplegic solutions. In: Isselhard W editor. Myocardial protection for cardiovascular surgery. Pharmazeutische Verlagsgesellschaft, Munchen: 1981.

    Google Scholar 

  23. Rowan AN. Laboratory animals and alternatives in the 80’s. Int J Study Animal Problems 1980; 1: 162–169.

    Google Scholar 

  24. Wessler S. Introduction: what is a model? In: Animal models of thrombosis and hemorrhagic diseases. Bethesda, Maryland: Nat. Inst. Health, 1976: XI-XVI.

    Google Scholar 

  25. ILAR National Research Council committee on Animal Models for Research on Aging. Mammalian models for research on aging. Washington, D.C.: National Academy Press, 1981.

    Google Scholar 

  26. Held JR. Appropriate animal models. In: Sechzer JA editor. The role of amimal in biomedical research. Annals New York Academy of Sciences, 1983; 406: 13–19.

    Google Scholar 

  27. Gill THJ. The use of randomly bred and genetically defined animals in biomedical research. Am J Pathol 1981; 100; 21–32.

    Google Scholar 

  28. Jones TC. The value of animal models. Am J Pathol 1981; 101: 3–9.

    Google Scholar 

  29. Leader RW. Padgett GA: The genesis and validation of animal models. Am J Pathol 1981; 101: 11–17.

    Google Scholar 

  30. Festing FW. Inbred strains in biöchemical re-

    Google Scholar 

  31. Jay GE. Genetic strains and stocks. In: Durdette WJ, editor: Methodology in mammalian genetics. Holden-Day, San Francisco: 1963: 83–126.

    Google Scholar 

  32. Bustad LK, Hegreberg GA, Padgett GA. Animal models. In: The future of animals, cells, models and systems in research development, education and testing. Nat. Academy of Sciences, 1977.

    Google Scholar 

  33. Andrews EJ, Ward BC, Altman NH, editors. Spontaneous models of human diseases. Academic Press, 1979.

    Google Scholar 

  34. Szabo S. Animal model of human disease: duodenal ucler disease. Animal model: cysteamineinduced acute and chronic duodenal ulcer in the rat. Amer J Pathol 1978; 93, 273–276.

    CAS  Google Scholar 

  35. Szabo S, Haith LR Jr, Reynolds ES. Pathogenesis of duodenal ulceration produced by cysteamine or proprionitrile: influence of vagotomy, sympathectomy, histamine depletion, FL-receptor antagonists and hormones. Am J Dig Dis 1979; 24, 471–474.

    Article  CAS  Google Scholar 

  36. Brady JV. Ulcers in “Executive” Monkeys. Sci Am 1958; 199: 99–100.

    Article  Google Scholar 

  37. Szabo S. Discussion. Am J Pathol 1980; 100: 78–82.

    Google Scholar 

  38. Cornelius CE. Animal models: a neglected medical resource. N Engl J Med 1969; 281: 933–944.

    Article  Google Scholar 

  39. McPeek B. Darstellung von Elementen des Designs and derer Analyse in klinischen Studien. In: Rohde H, Troidl H, editors. Das Margenkarzinom, 1984; 35–39.

    Google Scholar 

  40. Pollock AV. Design and interpretation of clinical trials Br Med J 1985; 290: 243.

    CAS  Google Scholar 

  41. Juhr NC. Die Optimierung des Tierversuchs-Aufgabe einer Tierversuchskunde. In: Kuebler K editor. Der Tierversuch in der Arzneimittelforschung BGA berichte. 1981; 1, 57–62.

    Google Scholar 

  42. Held JR. Muhlbock memorial lecture: consideration in the provision and characterization of animal models. In: Spiegel A, Erichsen S, Solleveld HA, editors. Animal quality and models in biomedical research. Stuttgart, New York: G. Fischer Verlag, 1980; 9–16.

    Google Scholar 

  43. Immich H. Medizinische Statistik F.K. Stuttgart, New York: Schattauer Verlag, 1974.

    Google Scholar 

  44. Dixon WJ. The up-and-down method for small samples Am. Statis. Assoc., 1965; 60: 967–978.

    Article  Google Scholar 

  45. Hsu CK, New AW, Mayo JJ. Quality assurance of rodent models. 7th ICLAS Symp., Utrecht 1979 G. Fischer, Stuttgart, New York: 1979; 17–28.

    Google Scholar 

  46. Bonnod J. Principles of ethics in animal experimentation. 16th IABS Congress: the standardization of animals to improve biomedical research, production and control. San Antonio 1979, Develop Biol Standard. S. Karger, Basel 1980; 45: 185–187.

    CAS  Google Scholar 

  47. Rowsell HC. The ethics of biomedical experimentation. In: the future of animals, cells, models and systems in research, development, education, and testing. Washington, D.C.: National Academy of Sciences, 1977.

    Google Scholar 

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Isselhard, W.H., Kusche, J. (1986). Animal Experimentation. In: Troidl, H., Spitzer, W.O., McPeek, B., Mulder, D.S., McKneally, M.F. (eds) Principles and Practice of Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96942-3_16

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  • DOI: https://doi.org/10.1007/978-3-642-96942-3_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-96944-7

  • Online ISBN: 978-3-642-96942-3

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