Abstract
Papillomas usually appear as single masses attached to the mucosa by a narrow stalk, and extend into the esophageal lumen. Zinc-deficient rats treated with a carcinogen develop numerous, often confluent tumors which may obstruct the esophagus, leading to rapid deterioration of the animal. Figure 251 illustrates the gross appearance of esophageal neoplasms in a control (A) and a zinc-deficient rat (B). Each rat was treated identically with methylbenzylnitrosamine (MBN) and killed after the same period. The marked increase in number of tumors and their confluence in the deficient animal is readily apparent.
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References
Ahmed SB, Russell RM (1982) The effect of ethanol feeding on zinc balance and tissue zinc levels in rats maintained on zinc-deficient diets. J Lab Clin Med 100: 211–217
Bradshaw E, Schonland M (1974) Smoking, drinking and oesophageal cancer in African males of Johannesburg, South Africa. Br J Cancer 30: 157–163
Chilvers C, Fraser P, Beral V (1979) Alcohol and oesophageal cancer: an assessment of the evidence from routinely collected data. J Epidemiol Community Health 33: 127–133
Doll R (1969) The geographical distribution of cancer. Br J Cancer 23:1–8
Fong LYY, Sivak A, Newberne PM (1978) Zinc deficiency and methylbenzylnitrosamine-induced esophageal cancer in rats. JNCI 61: 145–150
Gabrial GN, Schrager TF, Newberne PM (1982) Zinc deficiency, alcohol, and a retinoid: association with esophageal cancer in rats. JNCI 68: 785–789
Gatei DG, Odhiambo PA, Orinda DAO, Muruka FJ, Wasunna A (1978) Retrospective study of carcinoma of the esophagus in Kenya. Cancer Res 38: 303–307
Gates O, Warren S (1968) Radiation-induced experimental cancer of the esophagus. Am J Pathol 53: 667–685
Hormozdiari H, Day NE, Aramesh B, Mahboubi E (1975) Dietary factors and esophogeal cancer in the Caspian littoral of Iran. Cancer Res 35: 3493–3498
Joint Iran-IARC Study Group (1977) Esophageal cancer studies in the Caspian littoral of Iran: results of population studies — a prodrome. JNCI 59:1127–1138
Keller AZ (1980) The epidemiology of esophageal cancer in the west. Prev Med 9: 607–612
Lin HJ, Chan WC, Fong YY, Newberne PM (1977) Zinc levels in serum, hair and tumors from patients with esophageal cancer. Nutr Rep Int 15: 635–643
Lipworth LL, Rice CA (1979) Correlations in mortality data involving cancers of the colorectum and esophagus. Cancer 43: 1927–1933
Long EL, Jenner PM (1963) Esophageal tumors produced in rats by the feeding of dihydrosafrole. Fed Proc 22: 275
Magee PN, Schoental R (1964) Carcinogenesis by nitroso compounds. Br Med Bull 20: 102–106
Marasas WF, van Rensburg SJ, Mirocha CJ (1979) Incidence of fusarium species and the mycotoxins, deoxynivalenol and zearalenone, in corn produced in esophageal cancer areas in Transkei. J Agric Food Chem 27: 1108–1112
Mettlin C, Graham S, Priore R, Marshall J, Swanson M (1981) Diet and cancer of the esophagus. Nutr Cancer 2: 143–147
Ming S-C (1973) Tumors of the esophagus and stomach. In: Firminger HI (ed) Atlas of tumor pathology, second series, fascicle 7. AFIP, Washington DC
Mobarhan S, Russell RM, Newberne PM, Ahmed SB (1984) The effect of zinc deficiency and alcohol feeding on esophageal epithelium of rats. Nutr Rep Int 29: 639–645
Napalkov NP, Pozharisski KM (1969) Morphogenesis of experimental tumors of the esophagus. JNCI 42: 927–940
National Academy of Sciences (NAS) (1982) Diet, nutrition and cancer. National Academy, Washington DC, chap 17, p 391
Newberne PM, McConnell RG (1982) Neoplasms of the digestive system. In: Foster H, Small JD, Fox JG (eds) The mouse in biomedical research, vol IV. Experimental biology and oncology. Academic, New York, chap 27
Newberne PM, Schrager T (1983) Promotion of gastrointestinal tract tumors in animals: dietary factors. Environ Health Perspect 50: 71–83
Pottern LM, Morris LE, Blot WJ, Zeigler RG, Fraumeni JF Jr (1981) Esophageal cancer among black men in Washington, D. C. I. Alcohol, tobacco and other risk factors. JNCI 67: 777–783
Russell RM (1980) Vitamin A and zinc metabolism in alcoholism. Am J Clin Nutr 33: 2741–2749
Schmidt W, Popham RE (1981) The role of drinking and smoking in mortality from cancer and other causes in male alcoholics. Cancer 47: 1031–1041
Schutte KH (1968) Esophogeal tumors in sheep: some ecological observations. JNCI 41: 821–824
Seibold HR, Bailey WS, Hoerlein BF, Jordan EM, Schwabe CW (1955) Observations on the possible relation of malignant esophageal tumors and Spirocerca lupi lesions in the dog. Am J Vet Res 16: 514
Tuyns AJ, Pequignot G, Abbatucci JS (1979) Oesophageal cancer and alcohol consumption; importance of type of beverage. Int J Cancer 23: 443–447
Williams RR, Horm JW (1977) Association of cancer sites with tobacco and alcohol consumption and socioeconomic status of patients: interview study from the Third National Cancer Survey. JNCI 58: 525–547
Yang CS (1980) Research on esophageal cancer in China: a review. Cancer Res 40: 2633–2644
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Newberne, P.M. (1985). Papilloma and Squamous Cell Carcinoma, Esophagus, Rat (Zinc Deficiency, Alcohol, and Methylbenzylnitrosamine). In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Digestive System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96910-2_48
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DOI: https://doi.org/10.1007/978-3-642-96910-2_48
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