Papilloma and Squamous Cell Carcinoma, Esophagus, Rat (Zinc Deficiency, Alcohol, and Methylbenzylnitrosamine)
Papillomas usually appear as single masses attached to the mucosa by a narrow stalk, and extend into the esophageal lumen. Zinc-deficient rats treated with a carcinogen develop numerous, often confluent tumors which may obstruct the esophagus, leading to rapid deterioration of the animal. Figure 251 illustrates the gross appearance of esophageal neoplasms in a control (A) and a zinc-deficient rat (B). Each rat was treated identically with methylbenzylnitrosamine (MBN) and killed after the same period. The marked increase in number of tumors and their confluence in the deficient animal is readily apparent.
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