Squamous Cell Papilloma, Esophagus, Rat

  • Maria Yolanda Ovelar
  • Antonio Cardesa
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Papillomas appear as wart-like lesions, varying in size from 0.1 to 0.5 cm in diameter. They may be either peduncular with a long thins stalk, or sessile with a short broad stalk. They usually appear as multiple lesions disseminated throughout the entire mucosal surface of the esophagus, although they have tendency to locate more commonly at the areas of anatomic narrowing of the esophagus: the pharyngeo-esophageal junction, the anulus at the bifurcation of the trachea, and the cardial region (Fig. 238).


Keratotic papilloma hyperkeratotic papilloma nonkeratizing papilloma papillomatosis 


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  1. Cardesa A, Ovelar MY, Mohr U (1982) Experimental esophageal neoplasms in the rat: histogenetic pathways and comparison with the developmental stages of cancer of the esophagus in man. In: Pfeiffer CJ (Ed) Cancer of the esophagus, vol II. CRC, Boca Raton, Fl, chap 13, pp 199–213Google Scholar
  2. Herrold KM (1966) Epidermoid carcinomas of esophagus and forestomach induced in Syrian hamsters by N-nitroso-N-methylurethan. JNCI 37: 389–394PubMedGoogle Scholar
  3. Horie A, Hohchi S, Kuratsune M (1965) Carcinogenesis in the esophagus. II Experimental production of esophageal cancer by administration of ethanolic solution of carcinogens. Gann 56: 429–441PubMedGoogle Scholar
  4. Ito N, Kamamoto Y, Hiasa Y, Makiura S, Marugami M, Yokota Y, Sugihara S, Hirao K (1971) Histopathological and ultrastructural studies on esophageal tumors in rats treated with N-nitrosopiperidine. Gann 62: 445–451PubMedGoogle Scholar
  5. Levison DA, Hopwood D, Morgan RGH, Coghill G, Milne G A, Wormsley KG (1979) Oesophageal neoplasia in male Wistar rats due to parenteral di(2-hydroxylpropyl)-nitrosamine (DHPN): a combined histopathological, histochemical and electron microscopic study. J Pathol 129: 31–361PubMedCrossRefGoogle Scholar
  6. Ming S-C (1973) Tumors of the esophagus and stomach. In: Atlas of tumor pathology, 2nd ser, fasc 7. Armed Forces Institute of Pathology, Washington, DC, p 11Google Scholar

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© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Maria Yolanda Ovelar
  • Antonio Cardesa

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