Polyoma Virus Infection, Salivary Glands, Mouse

  • Stephen W. Barthold
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Tumors arise in many organs, particularly parotid salivary glands, following inoculation of neonatal mice. Submaxillary and sublingual salivary glands, as well as lacrimal glands and accessory mucous and serous glands of the head and neck are also affected. Salivary tumors are bilateral or unilateral, multilobular, usually well circumscribed, and up to 5 cm in diamter. Small tumors are soft, tan to gray, and bulge on cut surface. Larger tumors can have pseudocystic, mucoid centers and hemorrhage and occasionally ulcerate the overlying skin. Other common tumor sites are renal cortex, thymus, mammary gland, skin, subcutis, bone, mesothelium, adrenal, and less commonly, elsewhere. Liver, lung, and pancreas are frequant sites for metastases (Dawe 1979; Stewart 1960). Prior to tumor development, pups are runted with thymic atrophy. Small nodules on the costochondral and costovertebral junctions are often seen (Buffet and Levinthal 1962).


SE (Stewart-Eddy) polyoma virus parotid tumor virus infection 


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© Springer-Verlag Berlin Heidelberg 1985

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  • Stephen W. Barthold

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