Abstract
Foci of altered hepatocytes are not visible with the naked eye.
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References
Abmayr W, Demi E, Oesterle D, Gössner W (1983) Nuclear morphology in preneoplastic lesions of rat liver. Anal Quant Cytol 5: 275–284
Altmann H W (1978) Pathology of human liver tumors. In: Remmer H, Bolt HM, Bannasch P, Popper H (eds) Primary liver tumors. University Park, Baltimore, pp 53–51
Altmann HW, Osterland U (1961) Über cytoplasmatische Wirbelbildungen in den Leberzellen der Ratte bei chronischer Thioacetamidvergiftung. Beitr Path Anat 124: 1–18
Bannasch P (1968) The cytoplasm of hepatocytes during carcinogenesis. Recent Results Cancer Res 19:1–10
Bannasch P (1975) Die Cytologie der Hepatocarcinoge-nese. In: Altmann H W et al. (Hrsg) Handbuch der Allgemeinen Pathologie. VI/7. Springer, Berlin Heidelberg New York, pp 123–276
Bannasch P (1976) Cytology and cytogenesis of neoplastic (hyperplastic) hepatic nodules. Cancer Res 36: 2555–2562
Bannasch P (1983) Strain and species differences in the susceptibility to liver tumour induction. IARC Sci Publ 51:9–38
Bannasch P, Müller HA (1964) Lichtmikroskopische Untersuchungen über die Wirkung von N-Nitrosomor-pholin auf die Leber von Ratte und Maus. Arzneim Forsch 14: 805–814
Bannasch P, Mayer D, Hacker HJ (1980) Hepatocellular glycogenosis and hepatocarcinogenesis. Biochim Biophys Acta 605: 217–245
Bannasch P, Moore MA, Klimek F, Zerban H (1982) Biological markers of preneoplastic foci and neoplastic nodules in rodent liver. Toxicol Pathol 10:19–36
Bannasch P, Benner U, Hacker H (1984 a) Tigroid cell foci and their possible relation to hepatic tumors. In: van Bezooijen CFA (ed) Pharmacological, morphological and physiological aspects of liver aging. Eurage, Rijswijk, pp 195–204
Bannasch P, Hacker H, Klimek F, Mayer D (1984b) Hepatocellular glycogenosis and related pattern of enzymatic changes during hepatocarcinogenesis. Adv Enzyme Reguł 22:97–121
Bannasch P, Moore MA, Hacker HJ, Klimek F, Mayer D, Enzmann H, Zerban H (1985) Potential significance of phenotypic instability in focal and nodular liver lesions induced by hepatocarcinogens. In: Brunner H, Thaler H (eds) Hepatology 1983. Raven, New York, pp 191–209
Bruni C (1973) Distinctive cells similar to fetal hepatocytes associated with liver carcinogenesis by diethylnitrosa-mine. Electron microscopic study. JNCI 50: 1513–1528
Buchmann A, Kuhlmann WD, Schwarz M, Kunz HW, Wolf CR, Moll E, Friedberg T, Oesch F (1985) Regulation and expression of four cytochrome P-450 isoenzymes, NADPH-cytochrome P-450 reductase, the glutathione transferases B and C and microsomal epoxide hydrolase in preneoplastic and neoplastic lesions in rat liver. Carcinogenesis 6: 513–521
Burek JD (1978) Age-associated pathology. In: Pathology of aging rats. CRC, Boca Raton FL, chap 4, pp 58–68
Daoust R, Calamai R (1971) Hyperbasophilic foci as sites of neoplastic transformation in hepatic parenchyma. Cancer Res 31:1290–1296
Emmelot P, Scherer E (1980) The first relevant stage in rat liver carcinogenesis. A quantitative approach. Biochim Biophys Acta 605: 247–304
Farber E (1980) The sequential analysis of liver cancer induction. Biochim Biophys Acta 605:149–166
Fischer G, Ullrich D, Katz N, Bock WK, Schauer A (1983) Immunohistochemical and biochemical detection of uridine-diphosphate-glucuronyltransferase (UDP-GT) activity in putative preneoplastic liver foci. Virchows Arch (Cell Pathol) 42:193–200
Friedrich-Freksa H, Papadopulu G, Gössner W (1969) Histochemische Untersuchungen der Cancerogenese in der Rattenleber nach zeitlich begrenzter Verabfolgung von Diäthylnitrosamin. Z Krebsforsch 72: 240–253
Grundmann E, Sieburg H (1962) Die Histogenese und Cy-togenese des Lebercarcinoms der Ratte durch Diäthylnitrosamin im lichtmikroskopischen Bild. Beitr Path Anat 126: 57–90
Hacker HJ, Moore MA, Mayer D, Bannasch P (1982) Correlative histochemistry of some enzymes of carbohydrate metabolism in preneoplastic and neoplastic lesions in the rat liver. Carcinogenesis 3: 1265–1272
Hirota N, Williams GM (1982) Ultrastructural abnormalities in carcinogen-induced hepatocellular altered foci identified by resistance to iron accumulation. Cancer Res 42: 2298–2309
Irac, NRC (1980) Histological typing of liver tumors of the rat. JNCI 64:179–206
Kalengayi MMR, Desmet VJ (1975) Sequential histological and histochemical study of the rat liver during anatoxin B1-induced carcinogenesis. Cancer Res 35: 2845–2852
Karasaki S (1969) The fine structure of proliferating cells in preneoplastic rat livers during azo-dye carcinogenesis. J Cell Biol 40: 322–335
Kitagawa T (1971) Histochemical analysis of hyperplastic lesions and hepatomas of the liver of rats fed 2-fiuoren-ylacetamide. Gann 62: 207–216
Klimek F, Mayer D, Bannasch P (1984) Biochemical microanalysis of glycogen content and glucose-6-phos-phate dehydrogenase activity in focal lesions of the rat liver induced by N-nitrosomorpholine. Carcinogenesis 5:265–268
Kuhlmann WD, Krischan R, Kunz W, Guenthner TM, Oesch F (1981) Focal elevation of liver microsomal epoxide hydrolase in early preneoplastic stages and its behavior in the further course of hepatocarcinogenesis. Biochem Biophys Res Commun 98: 417–423
Kunz W, Schaude G, Schwarz M, Tennekes H (1982) Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications. In: Hecker E, Fusenig NE, Kunz W, Marks F, Thielmann HW (eds) Cocarcinogenesis and biological effects of tumour promoters, vol 7, Carcinogenesis — a comprehensive survey. Raven, New York, pp 111–125
Lowry OH, Passonneau JV (1972) A flexible system of enzymatic analysis. Academic, New York
Moore MA, Mayer D, Bannasch P (1982) The dose-dependence and sequential appearance of putative preneoplastic populations induced in the rat liver by stop experiments with N-nitrosomorpholine. Carcinogenesis 3:1429–1436
Moore MA, Hacker HJ, Bannasch P (1983) Phenotypic instability in focal and nodular lesions induced in a short term system in the rat liver. Carcinogenesis 4:595–603
Ogawa K, Medline A, Farber E (1979) Sequential analysis of hepatic carcinogenesis. A comparative study of the ultrastructure of preneoplastic, malignant, prenatal, postnatal, and regenerating liver. Lab Invest 41: 22–35
Opie EL (1946) Mobilization of basophile substance (ribonucleic acid) in the cytoplasm of liver cells with the production of tumors by butter yellow. J Exp Med 84: 91–106
Pitot HC, Sirica AE (1980) The stages of initiation and promotion in hepatocarcinogenesis. Biochim Biophys Acta 605:191–215
Porter KR, Bruni C (1959) An electron microscope study of the early effects of 3’-Me-DAB on rat liver cells. Cancer Res 19:997–1009
Rabes HM (1983) Development and growth of early preneoplastic lesions induced in the liver by chemical carcinogens. J Cancer Res Clin Oncol 106: 85–92
Rabes HM, Bücher Th, Hartmann A, Linke I, Dünnwalkd M (1982) Clonal growth of carcinogen-induced enzyme-deficient preneoplastic cell populations in mouse liver. Cancer Res 42: 3220–3227
Reznik-Schüller HM, Gregg M (1983) Sequential morphologic changes during methapyrilene-induced hepatocellular carcinogenesis in rats. JNCI 71:1021–1031
Romen W, Ross W, Bannasch P (1972) Cytomorpholo-gische und morphometrische Studien der Hepatocarci-nogenese. II. Die Reversibilität von Kerngrößenänderungen in der Nitrosomorpholin-vergifteten Rattenleber. Z Krebsforsch 77:134–140
Romen W, Bannasch P, Aziz A, Reuss W (1973) Karyoki-nese und Kernstruktur während der Hepatocarcinoge-nese. II. Die Feinstruktur des Zellkerns in Hepatozyten und Hepatomzellen der Nitrosomorpholin-vergifteten Rattenleber. Virchows Arch (Cell Pathol) 13:267–296
Schauer A, Kunze E (1968) Enzymhistochemische und autoradiographische Untersuchungen während der Can-cerisierung der Rattenleber mit Diäthylnitrosamin. Z Krebsforsch 70: 252–266
Schauer A, Kunze E (1976) Tumors of the liver. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol I, Tumours of the rat, part 2. IARC Sci Publ no 6, Lyon, pp 41–72
Scherer E, Emmelot P (1976) Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis. Cancer Res 36: 2544–2554
Scherer E, Hoffmann M (1971) Probable clonal genesis of cellular islands induced in rat liver by diethylnitros-amine. Eur J Cancer 7: 369–371
Schulte-Hermann R, Roome N, Timmermann-Trosiener I, Schuppler J (1984) Immunocytochemical demonstration of a phenobarbital-inducible cytochrome P-450 in putative preneoplastic foci of rat liver. Carcinogenesis 5: 143–153
Solt D, Farber E (1976) New principle for the analysis of chemical carcinogenesis. Nature 263: 701–703
Squire RA, Levitt MH (1975) Report of a workshop on classification of specific hepatocellular lesions in rats. Cancer Res 35: 3214–3223
Steiner JW, Miyai K, Phillips MJ (1964) Electron microscopy of membrane-particle arrays in liver cells of ethio-nine-intoxicated rats. Am J Pathol 44:169–213
Stenger RJ (1966) Concentric lamellar formations in hepatic parenchymal cells of carbon tetrachloride-treated rats. J Ultrastruct Res 14: 240–253
Taper HS, Bannasch P (1976) Histochemical correlation between glycogen, nucleic acids and nucleases in preneoplastic and neoplastic lesions of rat liver after short term administration of N-nitrosomorpholine. Z Krebsforsch 87: 53–65
Taper HS, Bannasch P (1979) Histochemical differences between so-called megalocytosis and neoplastic or preneoplastic liver lesions induced by N-nitrosomor-pholine. Eur J Cancer 15:189–196
Tatematsu M, Takano T, Hasegawa R, Imaida K, Nakanowatari J, Ito N (1980) A sequential quantitative study of the reversibility or irreversibility of liver hyperplastic nodules in rats exposed to hepatocarcinogens. Gann 71: 843–855
Theodossiou A, Bannasch P, Reuss R (1971) Glykogen und endoplasmatisches Retikulum der Leberzelle nach hohen Dosen des Carcinogens N-Nitrosomorpholin. Virchows Arch (Cell Pathol) 7:126–146
Ward JM (1981) Morphology of foci of altered hepatocytes and naturally-occurring hepatocellular tumors in F 344 rats. Virchows Arch (Pathol Anat) 390: 339–345
Weber G (1982) Differential carbohydrate metabolism in tumor and host. In: Arnott MS, Van Eys J, Wang Y-M (eds) Molecular interrelations of nutrition and cancer. Raven, New York, pp 191–208
Williams GM (1976) Functional markers and growth behaviour of preneoplastic hepatocytes. Cancer Res 36: 2540–2543
Williams GM (1980) The pathogenesis of rat liver cancer caused by chemical carcinogens. Biochim Biophys Acta 605:167–189
Williams GM, Watanabe K (1978) Quantitative kinetics of development of iV-2-fluorenylacetamide-induced, altered (hyperplastic) hepatocellular foci resistant to iron accumulation and of their reversion or persistence following removal of carcinogen. JNCI 61:113–121
Williams GM, Klaiber M, Parker SE, Farber E (1976) Nature of early appearing, carcinogen-induced liver lesions resistant to iron accumulation. JNCI 57:157–165
Willis RA (1967) Pathology of tumours. Butterworth, London
Wu PC, Lai CL, Lam KC, Lok ASF, Lin HJ (1983) Clear cell carcinoma of liver. An ultrastructural study. Cancer 52:504–507
Zerban H, Rabes H, Bannasch P (1985) Proliferation kinetics during hepatocarcinogenesis. Eur J Cancer (in press)
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Bannasch, P., Zerban, H., Hacker, H.J. (1985). Foci of Altered Hepatocytes, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Digestive System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96910-2_2
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