Nutritional Fatty Liver and Cirrhosis, Rat, Mouse

  • Paul M. Newberne
  • Adrianne E. Rogers
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


As lipid accumulates in the liver, it loses its mahogany-brown color and becomes beige or yellowish. The weight of the liver is reduced and it is bouyant when immersed in aqueous solution. Its cut surface is friable and oily in texture. Increased fibrous connective tissue gives the surface of the liver a roughened appearance and divides the liver parenchyma into grossly visible lobules or sub-lobules of various size (Fig. 82).


Alcoholic cirrhosis nutritional cirrhosis 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abanobi SE, Lombardi B, Shinozuka H (1982) Stimulation of DNA synthesis and cell proliferation in the liver of rats fed a choline-devoid diet and their suppression by phénobarbital. Cancer Res 42:412–415PubMedGoogle Scholar
  2. Copeland DH, Salmon WD (1946) The occurrence of neoplasms in the liver, lungs and other tissues of rats as a result of prolonged choline deficiency. Am J Pathol 22: 1059–1079Google Scholar
  3. Davidson CS (1970) Nutrition, geography and liver diseases. Am J Clin Nutr 23:427–436PubMedGoogle Scholar
  4. Engel RW, Salmon WD (1941) Improved diets for nutritional and pathologic studies of choline deficiency in young rats. J Nutr 22:109–121 + 2 platesGoogle Scholar
  5. Gibson JB, Wu PC, Ho JC, Lauder IJ (1980) Hepatitis B surface antigen, hepatocellular carcinoma and cirrhosis in Hong Kong: a necropsy study: 1963–1976. Br J Cancer 42: 370–377PubMedCrossRefGoogle Scholar
  6. Glinos AD, Bücher NLR, Aub JC (1951) The effect of liver regeneration on tumor formation in rats fed 4-dimethyl-aminoazobenzene. J Exp Med 93: 313–325PubMedCrossRefGoogle Scholar
  7. Grasso P, Hardy J (1975) Strain difference in natural incidence and response to carcinogens. In: Butler WH, Newbeme PM (eds) Mouse hepatic neoplasia. Elsevier, New York, pp 111–132Google Scholar
  8. Hartroft WS (1963) Experimental hepatic injury. In: Schiff L (ed) Diseases of the liver. Lippincott, PhiladelphiaGoogle Scholar
  9. Hoffbauer FW (1959) Fatty cirrhosis in the rat. A method of grading specimens. Arch Pathol 68:160–170Google Scholar
  10. Hutt MSR (1971) Epidemiology of human primary liver cancer. In: Liver cancer. I ARC Sci Publ No 1, Lyon, pp 21–29Google Scholar
  11. Lieber CS, Rubin E, DeCarli LM (1971) Effects of ethanol on lipid, uric acid, intermediary and drug metabolism, including the pathogenesis of the alcoholic fatty liver. In: Kissin B, Begleiter H (eds) The biology of alcoholism, vol 1. Plenum, New YorkGoogle Scholar
  12. MacSween RNM, Scott AR (1973) Hepatic cirrhosis: a clinicopathological review of 520 cases. J Clin Pathol 26: 936–942PubMedCrossRefGoogle Scholar
  13. Mikol YB, Hoover KL, Creasia D, Poirier LA (1983) Hep-atocarcinogenesis in rats fed methyl-deficient, amino acid-defined diets. Carcinogenesis 4:1619–1629PubMedCrossRefGoogle Scholar
  14. Newbeme PM (1985) Lipotropic factors and oncogenesis. In: Poivier L (ed) Role of nutrients in carcinogenesis. JNCI MonographGoogle Scholar
  15. Newbeme PM, Clark AJ (1982) Promotion of liver tumors in male B6C3F! mice by partial hepatectomy or dietary choline deficiency. Toxicologist 1:63Google Scholar
  16. Newbeme PM, Connor M (1980) Effects of sequential exposure to aflatoxin Bt and diethylnitrosamine on vascular and stomach tissue and additional target organs in rats. Cancer Res 40:4037–4042Google Scholar
  17. Newbeme PM, McConnell RG (1980a) Dietary nutrients and contaminants in laboratory animal experimentation. J Environ Pathol Toxicol 4 (5,6): 105–122Google Scholar
  18. Newbeme PM, McConnell RG (1980b) Toxicologic pathology: issues and uncertainties. In: Galli CL, Paoletti R (eds) Principles and methods in modem toxicology. Elsevier North Holland, Amsterdam, pp 223–258Google Scholar
  19. Newbeme PM, Thurman GB (1981) Working Group IV: lipids and the immune system. Report and recommendations. Cancer Res 41: 3803–3804Google Scholar
  20. Newbeme PM, Harrington DH, Wogan GN (1966) Effects of cirrhosis and other liver insults on induction of liver tumors by aflatoxin in rats. Lab Invest 15: 962–969Google Scholar
  21. Newbeme PM, Rogers AE, Bailey C, Young VR (1969) The induction of liver cirrhosis in rats by purified amino acid diets. Cancer Res 29: 230–235Google Scholar
  22. Newbeme PM, deCamargo JLV, Clark AJ (1982) Choline deficiency, partial hepatectomy and liver tumors in rats and mice. Toxicol Pathol 10:95–109CrossRefGoogle Scholar
  23. Newbeme PM, Rogers AE, Nauss KM (1983) Choline, methionine and related factors in oncogenesis. In: Butterworth CE Jr, Hutchinson ML (eds) Nutritional factors in the induction and maintenance of malignancy. Academic, New York, chap 15Google Scholar
  24. Okuda K, MacKay I (eds) (1982) Hepatocellular carcinoma, UICC Technical Report Series, vol 74, Rep No 17. UICC, GenevaGoogle Scholar
  25. Porta EA, Koch OR, Hartroft WS (1970) Recent advances in molecular pathology: a review of the effects of alcohol on the liver. Exp Mol Pathol 12:104–132PubMedCrossRefGoogle Scholar
  26. Rogers AE, MacDonald RA (1965) Hepatic vasculature and cell proliferation in experimental cirrhosis. Lab Invest 14:1710–1726PubMedGoogle Scholar
  27. Rogers AE, Newbeme PM (1969) Aflatoxin B1 carcinogenesis in lipotrope-deficient rats. Cancer Res 29: 1965–1972PubMedGoogle Scholar
  28. Rogers AE, Newberne PM (1971) Diet and anatoxin B1 toxicity in rats. Toxicol Appl Pharmacol 20:113–121PubMedCrossRefGoogle Scholar
  29. Rogers AE, Newberne PM (1975) Dietary effects on chemical carcinogenesis in animal models for colon and liver tumors. Cancer Res 35: 3427–3431PubMedGoogle Scholar
  30. Rogers AE, Newberne PM (1980) Lipotrope deficiency in experimental carcinogenesis. Nutr Cancer 2:104–112CrossRefGoogle Scholar
  31. Rogers AE, Fox JG, Murphy JC (1981) Ethanol and diet interactions in male rhesus monkeys. Drug-Nutr Interact 1:3–14PubMedGoogle Scholar
  32. Salmon WD, Copeland DH, Burns MJ (1955) Hepatomas in choline deficiency. JNCI 15 (Suppl): 1549–1551PubMedGoogle Scholar
  33. Tarone RE, Chu KC, Ward JM (1981) Variability in the rates of some common naturally occurring tumors in Fischer 344 rats and (C57BL/6N x C3H/HeN)F1 (B6C3F0 mice. JNCI 66:1175–1181PubMedGoogle Scholar
  34. Ward JM, Goodman DG, Squire RA, Chu KC, Linhart MS (1979) Neoplastic and nonneoplastic lesions in aging (C57BL/6NxC3H/HeN)F1 (B6C3Ft) mice. JNCI 63:849–854PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Paul M. Newberne
  • Adrianne E. Rogers

There are no affiliations available

Personalised recommendations