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Intranuclear and Intracytoplasmic Inclusions, Liver, Rat

  • Matthew J. van Zwieten
  • Carel F. Hollander
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

Intranuclear and intracytoplasmic inclusions are not visible grossly.

Synonyms

Inclusion bodies intranuclear cytoplasmic invagination cytoplasmic inclusions acidophilic inclusions hyaline droplets hyaline bodies 

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References

  1. Andrew W (1962) An electron microscope study of age changes in the liver of the mouse. Am J Anat 110:1–18PubMedCrossRefGoogle Scholar
  2. Andrew W, Brown HM, Johnson JB (1943) Senile changes in the liver of mouse and man, with special reference to the similarity of the nuclear alterations. Am J Anat 72: 199–221CrossRefGoogle Scholar
  3. Carr RD, Smith MJ, Keil PG (1960) The liver in the aging process. Histology. Arch Pathol 70:15–18Google Scholar
  4. Dekker A, Krause JR (1973) Hyaline globules in human neoplasms. A report of three autopsy cases. Arch Pathol 95:178–181PubMedGoogle Scholar
  5. Edwards JE, White J (1941) Pathologic changes, with special reference to pigmentation and classification of hepatic tumors in rats fed p-dimethylaminoazobenzene (butter yellow). JNCI 2:157–183Google Scholar
  6. Frith CH, Ward JM (1980) A morphologic classification of proliferative and neoplastic hepatic lesions in mice. J Environ Pathol Toxicol 3: 329–351Google Scholar
  7. Helyer BJ, Petrelli M (1978) Cytoplasmic inclusions in spontaneous hepatomas of CBA/H-T6T6 mice. Histochemistry and electron microscopy. JNCI 60: 861–869PubMedGoogle Scholar
  8. Herbst M (1976) Glycogenous hepatonuclear inclusions in the aged mouse — an electron microscopic study of the histogenesis of nuclear inclusions. Pathol Europ 11: 69–79Google Scholar
  9. Hollander CF (1967) Preliminary note on the relations between regenerative growth, ageing and tumor formation in the mouse liver. Epatologia 13: 447–454Google Scholar
  10. Hollander CF, Thung PJ (1966) Relations between regenerative growth and ageing in the mouse liver. In: Lindop PJ, Sacher GA (eds) Proc colloq on radiation and ageing. Taylor and Francis, London, pp 3–14Google Scholar
  11. Jacoby RO, Bhatt PN, Jonas AM (1979) Viral diseases. In: Baker HJ, Lindsey JR, Weisbroth SH (eds) The laboratory rat, vol I, Biology and diseases. Academic, New York, chap 11, pp 271–306Google Scholar
  12. Jones TC (1967) Pathology of the liver of rats and mice. In: Cotchin E, Roe FJC (eds) Pathology of laboratory rats and mice. Blackwell Scientific, Oxford, chap 1, pp 1–23Google Scholar
  13. Kleinfeld RG, Greider MH, Frajola WJ (1956) Electron microscopy of intranuclear inclusions found in human and rat liver parenchymal cells. J Biophys Biochem Cytol 2 (Suppl): 435–438PubMedCrossRefGoogle Scholar
  14. Lussier G, Pavilanis V (1968) Nuclear inclusions in the liver cells of the golden hamster. Can J Comp Med 32: 568–570PubMedGoogle Scholar
  15. McClure HM, Chapman WL Jr, Hooper BE, Smith FG, Fletcher OJ (1978) The digestive system. In: Benirschke K, Garner FM, Jones TC (eds) Pathology of laboratory animals, vol 1. Springer, New York Heidelberg Berlin, chap 4, pp 175–317CrossRefGoogle Scholar
  16. Nakanuma Y, Ohta G, Matsubara F, Wantanabe K, Doishita K (1982) Cytoplasmic blood plasma inclusions in human hepatocytes. Liver 2: 212–221PubMedGoogle Scholar
  17. Popper H, Paronetto F, Barka T (1960) PAS-positive structures of nonglycogenic character in normal and abnormal liver. Arch Pathol 70: 300–313PubMedGoogle Scholar
  18. Richter WR, Stein RJ, Rdzok EJ, Moize SM, Bischoff MB (1965) Ultrastructural studies of intranuclear crystalline inclusions in the liver of the dog. Am J Pathol 47: 587–599PubMedGoogle Scholar
  19. Rijhsinghani K, Krakower C, Swerdlow M, Abrahams C, Ghose T (1980) Alpha-1-antitrypsin in intracellular inclusions of diethylnitrosamine induced hepatomas of C57BL x C3HFt mice. Carcinogenesis 1:473–479PubMedCrossRefGoogle Scholar
  20. Ruebner BH, Lindsey JR, Melby EC Jr (1965) Hepatitis and other spontaneous liver lesions of small experimental animals. In: Ribelin WE, McCoy JR (eds) The pathology of laboratory animals. Thomas, Springfield, chap 7, pp 160–182Google Scholar
  21. Schauer A, Kunze E (1976) Tumours of the liver. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol I, Tumours of the rat, part 2. IARC Sci Publ No 6, Lyon, pp 41–72Google Scholar
  22. Wharton FP, Wright DJM (1977) Observations on a new liver inclusion in the mouse. Lab Anim 11:109–111PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Matthew J. van Zwieten
  • Carel F. Hollander

There are no affiliations available

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