Osteosarcoma and Chondrosarcoma
Osteosarcoma is one of the two common bone tumours which occur in childhood. Although it has been reported in a child of 3 years and can occur at almost any time during adult life, the peak age is between 10 and 20 years. Many of these tumours occurring in later life complicate Paget’s disease, which does not occur in children. The annual incidence of the tumour has been reported as 1.6–2.8 per million children under 15 years; it occurs more commonly in males (M : F ratio = 1.6 : 1).
KeywordsPrimary Osteogenic Sarcoma Bilateral Retinoblastoma Elevated Serum Alkaline Phosphatase Folinic Acid Rescue Tumour Compute Tomography
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- 2.Spiess H (1969) Ra244 — induced tumours in children and adults. In: Mays CW, Jee WSS, Lloyd RD, Stover BJ, Dougherty JH, Taylor GN (eds) Delayed effects of bone seeking radionuclides. University of Utah Press, Salt Lake City, pp 227–246Google Scholar
- 4.Abramson DH, Ellsworth RM, Zimmerman LE (1976) Nonocular cancer in retinoblastoma survivors. Trans Am Acad Ophthalmol Otolaryngol 81: OP454Google Scholar
- 5.Link M, Goorin A, Miser A, Green A, Pratt C, Belasco J, Pritchard J, Baker A, Kirkpatrick J, Ayala A, Shuster J, Abelson H, Simone J, Vietti T (1985) The role of adjuvant chemotherapy in the treatment of osteosarcoma of the extremity: Preliminary results of the multi-institutional osteosarcoma study. Proc ASCO C-924, p 237Google Scholar
- 6.Craft AW (1985) Controversies in the management of bone tumours. Cancer Surveys 3: 733–750Google Scholar
- 8.Winkler K, Beron G, Kotz R, Salzer-Kuntschik M, Beck J, Beck W, Brandeis W, Ebell W, Erltman R, Gobel U, Havers W, Henze G, Hinderfield L, Hocker P, Jobke A, Jurgens H, Kabisch H, Preusser P, Prindull G, Ramach W, Ritter J, Sekera J, Treuner J, Wust G, Landbeck G (1984) Neoadjuvant chemotherapy for osteogenic sarcoma: Results of a cooperative German/Austrian Study. J Clin Oncol 2: 617–624Google Scholar
- 9.Burgers JMV, Voûte PA, Van Glabbeke M (1985) Adjuvant chemotherapy for osteosarcoma of the limbs: Trial 20781 of the SIOP and EORTC Radiotherapy/Chemo therapy Group. In: Van Unnik (ed) The management of bone and soft tissue sarcomas. Raven, New York (in press)Google Scholar
- 10.Marcove RC, Miké V, Hajek JV, Levin AG, Hutter RVP (1970) Osteogenic sarcoma under the age of twenty-one. A review of one hundred and forty-five operative cases. J Bone Joint Surg [Am] 52: 411–423Google Scholar
- 12.Bellani FF, Gasparini M, Gennari L, Fontanillas L, Bonnadonna G (1979) Adjuvant treatment with adriamycin in primary operable osteosarcoma. Cancer Treat Rep 63: 1621–1627Google Scholar
- 13.Ochs JJ, Freeman AI, Douglass HO Jr, Higby DS, Mindell EP, Sinks LF (1978) cw-Dichlorodiammineplatinum ( II) in advanced osteogenic sarcoma. Cancer Treat Rep 62: 239–245Google Scholar
- 14.Rosen G, Huvos A, Mosende C, Beattie EJ Jr, Exelby PR, Capparos B, Marcove RC (1978) Chemotherapy and thoracotomy for metastatic osteogenic sarcoma. A model for adjuvant chemotherapy and the rationale for the time of thoracic surgery. Cancer 41: 841–849Google Scholar
- 16.Kotz R, Salzer M (1982) Rotationplasty for childhood osteosarcoma of the distal part of the femur. J Bone Joint Surg [Am] 64: 959–969Google Scholar
- 18.Jürgens H, Kosloff C, Nirenberg A, Mehta B, Huvos AG, Rosen G (1981) Prognostic factors in the response of primary osteogenic sarcoma to preoperative chemotherapy (high dose methotrexate with citrovorum factor). Natl Cancer Inst Monogr 56: 221–226Google Scholar