Squamous Cell Carcinoma, Nasal Mucosa, Rat

  • William D. Kerns
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

Clinically, squamous cell carcinomas, as well as all other malignant neoplasms of the nasal cavity, are invasive tumors that protrude dorsally or laterally from the nasal cavity (Fig. 84). Frequently, the epidermis overlying the tumor is ulcerated and necrotic. Often, during the early stages of tumor growth, a unilateral nasoocular discharge is observed; this can be associated with tumor growth and interference with nasolacrimal drainage. Once the tumor has penetrated the nasal or maxillary bones, its growth is rapid. Moribund rats exhibit marked dyspnea and emaciation.

Keywords

Formaldehyde Lignin Luminal Pyrene Neuroblastoma 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Albert RE, Sellakumar AR, Laskin S, Kuschner M, Nelson N, Snyder CA (1982) Gaseous formaldehyde and hydrogen chloride induction of nasal cancer in rats. JNCI 68: 597–603PubMedGoogle Scholar
  2. Andersen HC, Andersen I, Solgaard J (1977) Nasal cancers, symptoms and upper airway function in woodworkers. Br J Ind Med 34: 201–207PubMedGoogle Scholar
  3. Ash JE, Beck MR, Wilkes JD (1964) Atlas of tumor pathology. Tumors of the upper respiratory tract and ear. Armed Forces Institute of Pathology, Washington, DC, sect IV, fasc 12 and 13Google Scholar
  4. Brinton LA, Blot WJ, Stone BJ, Fraumeni JF Jr (1977) A death certificate analysis of nasal cancer among furniture workers in North Carolina. Cancer Res 37: 3473–3474PubMedGoogle Scholar
  5. Buiatti E, Geddes M, Carnevale F, Merler E (1983) Nasal cavity and paranasal sinus tumors in woodworkers and shoemakers in Italy compared to other countries. In: Reznik G, Stinson SF (eds) Nasal tumors in animals and man, vol 1. Anatomy, physiology and epidemiology. CRC, Boca Raton, chap 5Google Scholar
  6. Cardesa A, Pour P, Haas H, Althoff J, Mohr U (1976) Histogenesis of tumors from the nasal cavities induced by diethylnitrosamine. Cancer 37: 346–355PubMedCrossRefGoogle Scholar
  7. Collan Y (1983) Epidemiologic and etiologic aspects and histopathology of nasal carcinoma in Finland. In: Reznik G, Stinson SF (eds) Nasal tumors in animals and man, vol 1. Anatomy, physiology and epidemiology. CRC, Boca Raton, chap 4Google Scholar
  8. Cotchin E (1967) Spontaneous neoplasms of the upper respiratory tract in animals. In: Muir CS, Shanmugaratnam K (eds) Cancer of the naso-pharynx. International Union Against Cancer, Monogr series no 1, Medical Examination, Flushing, pp 203–215Google Scholar
  9. Feron VJ, Kruysse A, Woutersen RA (1982) Respiratory tract tumours in hamsters exposed to acetaldehyde vapour alone or simultaneously to benzo(a)pyrene or diethylnitrosamine. Eur J Cancer Clin Oncol 18: 13–31PubMedCrossRefGoogle Scholar
  10. Halperin WE, Goodman M, Stayner L, Elliott LJ, Keenlyside RA, Landrigan PJ (1983) Nasal cancer in a worker exposed to formaldehyde. JAMA 249: 510–512PubMedCrossRefGoogle Scholar
  11. Hoch-Ligeti C, Argus MF, Arcos JC (1970) Induction of carcinomas in the nasal cavity of rats by dioxane. Br J Cancer 24: 164–167PubMedCrossRefGoogle Scholar
  12. Isaka H, Yoshii H, Otsuji A, Koike M, Nagai Y, Koura M, Sugiyasu K, Kanabayashi T (1979) Tumors of SpragueDawley rats induced by long-term feeding of phenacetin. Gan 70: 29–36PubMedGoogle Scholar
  13. Jean R, Daudel R (1949) Épithélioma des sinus et des fosses nasales chez un cheval. Bull Sery Elev Indust Anim AOF 2: 15–21Google Scholar
  14. Kerns WD, Pavkov KL, Donofrio DJ, Gralla EJ, Swenberg JA (1983) Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res 43: 4382–4392PubMedGoogle Scholar
  15. Kociba RJ, McCollister SB, Park C, Torkelson TR, Gehring PJ (1974) 1,4-Dioxane. I. Results of a 2-year ingestion study in rats. Toxicol Appl Pharmacol 30: 275–286CrossRefGoogle Scholar
  16. Kuschner M, Laskin S, Drew RT, Cappiello V, Nelson N (1975) Inhalation carcinogenicity of alpha halo ethers. III. Lifetime and limited period inhalation studies with bis(chloromethyl)ether at 0.1 ppm. Arch Environ Health 30: 73–77PubMedGoogle Scholar
  17. Laskin S, Sellakumar AR, Kuschner M, Nelson N, La Mendola S, Rusch GM, Katz GV, Dulak NC, Albert RE (1980) Inhalation carcinogenicity of epichlorohydrin in noninbred Sprague-Dawley rats. JNCI 65: 751–757PubMedGoogle Scholar
  18. Lee KP, Trochimowicz Hi (1982) Induction of nasal tumors in rats exposed to hexamethylphosphoramide by inhalation. JNCI 68: 157–171PubMedGoogle Scholar
  19. Lee KP, Schneider PW, Trochimowicz HJ (1983) Morphologic expression of glandular differentiation in the epidermoid nasal carcinomas induced by phenylglycidyl ether inhalation. Am J Pathol 111: 140–148PubMedGoogle Scholar
  20. Madewell BR, Priester WA, Gillette EL, Snyder SP (1976) Neoplasms of the nasal passages and paranasal sinuses in domesticated animals as reported by 13 veterinary colleges. Am J Vet Res 37: 851–856PubMedGoogle Scholar
  21. Moulton JE (1978) Tumors of the respiratory system. In: Moulton JE (ed) Tumors in domestic animals. University of California Press, Berkeley, chap 6Google Scholar
  22. Nagle RB, McDaniel KM, Clark VA, Payne CM (1983) The use of antikeratin antibodies in the diagnosis of human neoplasms. Am J Clin Pathol 79: 458–466PubMedGoogle Scholar
  23. Nathrath WB, Wilson PD, Trejdosiewicz LK (1982) Immunohistochemical localisation of keratin and luminal epithelial antigen in myoepithelial and luminal epithelial cells of human mammary and salivary gland tumours. Pathol Res Pract 175: 279–288PubMedCrossRefGoogle Scholar
  24. Pavkov KL, Kerns WD, Mitchell RI, Connell MM, Donofrio DJ, Harroff HH (1981) A chronic inhalation toxicology study in rats and mice exposed to formaldehyde. In: Chemical Industry Institute of Toxicology Final Report, Dockett no. 10922 Battelle, Columbus Labs, ColumbusGoogle Scholar
  25. Reznik, G, Reznik-Schuller HM, Hayden DW, Russfield A, Murthy ASK (1981) Morphology of nasal cavity neoplasms in F344 rats after chronic feeding of p-cresidine, an intermediate of dyes and pigments. Anticancer Res 1: 279–286PubMedGoogle Scholar
  26. Reznik G, Reznik-Schuller HM, Ward JM, Stinson SF (1980a) Morphology of nasal-cavity tumours in rats after chronic inhalation of 1,2-dibromo-3-chloropropane. Br J Cancer 42: 772–781CrossRefGoogle Scholar
  27. Reznik G, Ulland B, Stinson SF, Ward JM (1980b) Morphology and sex-dependent manifestation of nasal tumors in B6C3F1 mice after chronic inhalation of 1,2-dibromo-3-chloropropane. J Cancer Res Clin Oncol 98: 75–83CrossRefGoogle Scholar
  28. Roush GC, Meigs JW, Kelly JA, Flannery JT, Burdo H (1980) Sinonasal cancer and occupation: a case-control study. Am J Epidemiol 111: 183–193PubMedGoogle Scholar
  29. Schoental R, Gibbard S (1972) Nasal and other tumours in rats given 3,4,5,-trimethoxy-cinnamaldehyde, a derivative of sinapaldehyde and other alpha, beta-unsaturated aldehydic wood lignin constituents. Br J Cancer 26: 504–505PubMedCrossRefGoogle Scholar
  30. Sellakumar AR, Laskin S, Kuschner M, Rusch G, Katz GV, Snyder CA, Albert RE (1980) Inhalation carcinogenesis by dimethylcarbamoyl chloride in Syrian golden hamsters. J Environ Pathol Toxicol 4: 107–115PubMedGoogle Scholar
  31. Stinson SF (1983) Nasal cavity cancer in laboratory animal bioassays of environmental compounds. In: Reznik G, Stinson SF (eds) Nasal tumors in animals and man, vol III. Experimental carcinogenesis, CRC, Boca Raton, chap 7Google Scholar
  32. Wilson PD, Nathrath WB, Trejdosiewicz LK (1982) Immunoelectron microscopic localisation of keratin and luminal epithelial antigens in normal and neoplastic urothelium. Pathol Res Pract 175: 289–298PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • William D. Kerns

There are no affiliations available

Personalised recommendations