Response to Carcinogens of Respiratory Epithelium, Syrian Golden Hamster (Mesocricetus Auratus)
Early changes that may lead to neoplasia, such as focal metaplasia with loss of ciliated epithelium and epidermoid metaplasia, hyperplasia and/or papillary dysplasia, cannot be observed macroscopically, whereas progressively exophytic growing papillary tumors, whether or not they fill the airway lumen, are easily detectable under a magnifying glass or a stereo microscope (Fig. 56). In addition to their typical form and shape (sessile or pedunculated), the tumors are soft and reddish gray, clearly distinguishable from the surrounding respiratory epithelium. Often such areas with small tumors are recognized by increased vascularization. After perfusion of the tissues with fixative solution, these neoplasms become a yellowish gray contrasting with the whitish adjacent epithelium.
KeywordsFormaldehyde Dust Hydrocarbon Adenoma Polycyclic Aromatic Hydrocarbon
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