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Epithelial Alterations in Explant Cultures of Fetal Tracheae of Syrian Golden Hamsters

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Respiratory System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

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Abstract

Various types of epithelial alterations have been observed in explant cultures of differentiated respiratory tissues which were treated in vitro with carcinogens (Lasnitzki 1956; Palekar et al. 1968; Crocker and Sanders 1970), infectious microorganisms (Gabridge 1979), mineral dusts (Mossman et al. 1980), and other airborne particulates (Mossman and Craighead 1979).

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References

  • Becci PJ, McDowell EM, Trump BF (1978) The respiratory epithelium. IV. Histogenesis of epidermoid metaplasia and carcinoma in situ in the hamster. JNCI 61: 577–586

    PubMed  CAS  Google Scholar 

  • Crocker TT, Sanders LL (1970) Influence of vitamin A and 3,7-dimethyl-2, 6-octadienal (citral) on the effect of benzo(a)pyrene on hamster trachea in organ culture. Cancer Res 30: 1312–1318

    PubMed  CAS  Google Scholar 

  • Emura M, Mohr U (1975) Morphological studies on the development of tracheal epithelium in the Syrian golden hamster. I. Light microscopy. Z Versuchstierkd 17: 14–26

    PubMed  CAS  Google Scholar 

  • Emura M, Richter-Reichhelm HB, Mohr U (1978) Epithelial alterations in fetal tracheal explants of Syrian golden hamsters exposed to diethylnitrosamine in utero. Cancer Lett 5: 115–121

    Article  PubMed  CAS  Google Scholar 

  • Emura M, Richter-Reichhelm HB, Emura KM, Matthei S, Mohr U (1979) Tubular expiant culture of fetal Syrian golden hamster tracheae. Exp Pathol 17: 196–199

    CAS  Google Scholar 

  • Gabridge MG (1979) Hamster tracheal organ cultures as models for infection and toxicology studies. Prog Exp Tumor Res 24: 85–95

    PubMed  CAS  Google Scholar 

  • Gould VE, Wenk R, Sommers SC (1971) Ultrastructural observations on bronchial epithelial hyperplasia and squamous metaplasia. Cancer 28: 426–436

    Article  PubMed  CAS  Google Scholar 

  • Harris CC, Sporn MB, Kaufman DG, Smith JM, Jackson FE, Saffiotti U (1972) Histogenesis of squamous metaplasia in the hamster tracheal epithelium caused by vitamin A deficiency or benzo(a)pyrene-ferric oxide. JNCI 48: 743–761

    PubMed  CAS  Google Scholar 

  • Keenan KP, Combs JW, McDowell EM (1982) Regeneration of hamster tracheal epithelium after mechanical injury. III. Large and small lesions: comparative stathmokinetic and single pulse and continuous thymidine labelling autoradiographic studies. Virchows Arch (Cell Pathol) 41: 231–252

    CAS  Google Scholar 

  • Lasnitzki I (1956) The effect of 3–4-benz-pyrene on human foetal lung grown in vitro. Br J Cancer 10: 510–516

    Article  PubMed  CAS  Google Scholar 

  • Marchok AC, Cone MV, Nettesheim P (1975) Induction of squamous metaplasia (vitamin A deficiency) and hyper-secretory activity in tracheal organ cultures. Lab Invest 33: 451–460

    PubMed  CAS  Google Scholar 

  • McDowell EM, Becci PJ, Schürch W, Trump BF (1979) The respiratory epithelium. VII. Epidermoid metaplasia of hamster tracheal epithelium during regeneration following mechanical injury. JNCI 62: 995–1008

    PubMed  CAS  Google Scholar 

  • Mohr U, Althoff J, Authaler A (1966) Diaplacental effect of the carcinogen diethylnitrosamine in the golden hamster. Cancer Res 26: 2349–2352

    PubMed  CAS  Google Scholar 

  • Mossman BT, Craighead JE (1979) Use of hamster tracheal organ cultures for assessing the cocarcinogenic effects of inorganic particulates on the respiratory epithelium. Prog Exp Tumor Res 24: 37–47

    PubMed  CAS  Google Scholar 

  • Mossman BT, Adler KB, Craighead JE (1980) Cytotoxic and proliferative changes in tracheal organ and cell cultures after exposure to mineral dusts. In: Brown RC, Gormley IP, Chamberlain M, Davis R (eds) The in vitro effects of mineral dusts. Academic, London, pp 241–250

    Google Scholar 

  • Palekar L, Kuschner M, Laskin S (1968) The effect of 3-methylcholanthrene on rat trachea in organ culture. Cancer Res 28: 2098–2104

    PubMed  CAS  Google Scholar 

  • Richter-Reichhelm HB, Emura M, Althoff J (1982) Scanning electron microscopical investigations on the respiratory epithelium of the Syrian golden hamster. IV. In vitro effects of dimethylsulphoxide and benzo(a)pyrene. Zentralbl Bakteriol Mikrobiol Hyg (B) 176: 269–276

    CAS  Google Scholar 

  • Trump BF, McDowell EM, Glavin F, Barrett LA, Becci PJ, Schürch W, Kaiser HE, Harris CC (1978) The respiratory epithelium. III. Histogenesis of epidermoid metaplasia and carcinoma in situ in the human. JNCI 61: 563–575

    PubMed  CAS  Google Scholar 

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© 1985 Springer-Verlag Berlin Heidelberg

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Emura, M. (1985). Epithelial Alterations in Explant Cultures of Fetal Tracheae of Syrian Golden Hamsters. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Respiratory System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96846-4_3

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  • DOI: https://doi.org/10.1007/978-3-642-96846-4_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-96848-8

  • Online ISBN: 978-3-642-96846-4

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