Bronchiolar/Alveolar Hyperplasia, Lung, Rat

  • Gary A. Boorman
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The lesion is generally not visible grossly but may appear as white pinpoint foci from the pleural surface.


Ciliated Cell Alveolar Epithelium Nickel Sulfide Pleural Surface Inhalation Study 
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  1. Aso Y, Yoneda K, Kikkawa Y (1976) Morphologic and biochemical study of pulmonary changes induced by bleomycin in mice. Lab Invest 35: 558–568PubMedGoogle Scholar
  2. Bocking A, Mittermayer C, von Deimling O (1981) Urethane-induced lung hyperplasia. Lab Invest 44: 138–143PubMedGoogle Scholar
  3. Boorman GA, Schwartz LW, Dungworth DL (1980) Pulmonary effects of prolonged ozone insult in rats. Lab Invest 43: 108–115PubMedGoogle Scholar
  4. Dormans JA (1983) The ultrastructure of various cell types in the lung of the rat: a survey. Exp Pathol 24: 15–33PubMedCrossRefGoogle Scholar
  5. Evans MJ, Cabral LJ, Stephens RJ, Freeman G (1975) Transformation of alveolar type II cells to type I cells following exposure to NO2. Exp Mol Pathol 22: 142–150PubMedCrossRefGoogle Scholar
  6. Evans MJ, Johnson LV, Stephens RI, Freeman G (1976) Cell renewal in the lungs of rats exposed to low levels of ozone. Exp Mol Pathol 24: 70–83PubMedCrossRefGoogle Scholar
  7. Jeffery PK, Reid L (1975) New observations of rat airway epithelium: a quantitative and electron microscopic study. J Anat 120: 295–320PubMedGoogle Scholar
  8. Kauffman SL (1980) Cell proliferation in the mammalian lung. Int Rev Exp Pathol 22: 131–191PubMedGoogle Scholar
  9. Kauffman SL, Alexander L, Sass L (1979) Histologic and ultrastructural features of the Clara cell adenoma of the mouse lung. Lab Invest 40: 708–716PubMedGoogle Scholar
  10. Mason RJ, Dobbs LG, Greenleaf RD, Williams MC (1977) Alveolar type II cells. Fed Proc 36: 2697–2702PubMedGoogle Scholar
  11. National Toxicology Program (NTP) (1983) Technical report series, National Technical Information Service, US Department of Commerce, SpringfieldGoogle Scholar
  12. Ottolenghi AD, Haseman JK, Payne WW, Falk HL, MacFarland HN (1975) Inhalation studies of nickel sulfide in pulmonary carcinogenesis of rats. JNCI 54: 1165–1172PubMedGoogle Scholar
  13. Pinkerton KE, Barry BE, O’Neil JJ, Raub JA, Pratt PC, Crapo JD (1982) Morphologic changes in the lung during the lifespan of Fischer 344 rats. Am J Anat 164: 155–174PubMedCrossRefGoogle Scholar
  14. Pour P, Stanton MF, Kuschner M, Laskin S, Shabad LM (1976) Tumours of the respiratory tract. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol 1. Tumours of the rat, part 2. IARC, Lyon, pp 1–40 (Publication no 6 )Google Scholar

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© Springer-Verlag Berlin Heidelberg 1985

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  • Gary A. Boorman

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