Bronchiolar/Alveolar Carcinoma, Lung, Rat

  • Gary A. Boorman
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

While small tumors may not be visible to the unaided eye, most bronchiolar/alveolar carcinomas are of sufficient size to be easily seen. They appear as firm, pale, white to pink irregular smooth nodules projecting above the pleural surface. In advanced cases an entire lobe may be replaced by tumorous tissue. While in man they are most often found in the upper lobe, a site propensity has not been reported for the rat. When cut most will have a smooth surface, except for those containing areas of necrosis, which will appear grossly as yellow to pale brown irregular areas of soft caseous material within the tumor.

Keywords

Nickel Toxicity Adenocarcinoma Adenoma Carbonyl 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anver MR, Cohen BJ, Lattuada CP, Foster SJ (1982) Age-associated lesions in barrier-reared male Sprague-Dawley rats: a comparison between Hap: (SD) and Crl: COPS(R)CD(R)(SD) stocks. Exp Aging Res 8: 3–24PubMedCrossRefGoogle Scholar
  2. Boorman GA, Hollander CF (1973) Spontaneous lesions in the female WAG/Rij ( Wistar) rat. J Gerontol 28: 152–159PubMedGoogle Scholar
  3. Burek JD, Hollander CF (1977) Incidence patterns of spontaneous tumors in BN/Bi rats. JNCI 58: 99–105PubMedGoogle Scholar
  4. Coleman GL, Barthold SW, Osbaldiston GW, Foster SF, Jonas AM (1977) Pathological changes during aging in barrier-reared Fischer 344 male rats. J Gerontol 32: 258–278PubMedGoogle Scholar
  5. Dermer GB (1982) Origin of bronchioloalveolar carcinoma and peripheral bronchial adenocarcinoma. Cancer 49: 881–887PubMedCrossRefGoogle Scholar
  6. Goodman DG, Ward JM, Squire RA, Paxton MB, Reichardt WD, Chu KC, Linhart MS (1980) Neoplastic and nonneoplastic lesions in aging Osborne-Mendel rats. Toxicol Appl Pharmacol 55: 433–447PubMedCrossRefGoogle Scholar
  7. Greenberg SD (1982) Histology and ultrastructure of bronchiolo-alveolar carcinoma. In: Shimosato Y, Melamed Gary A. Boorman MR, Nettesheim P (eds) Morphogenesis of lung cancer, vol 1. CRC, Boca Raton, pp 121–145Google Scholar
  8. Greenberg SD (1982) Histology and ultrastructure of bronchiolo-alveolar carcinoma. In: Shimosato Y, Melamed Gary A. Boorman MR, Nettesheim P (eds) Morphogenesis of lung cancer, vol 1. CRC, Boca Raton, pp 121–145Google Scholar
  9. Jacobs BB, Huseby RA (1967) Neoplasms occurring in aged Fischer rats with special reference to testicular, uterine and thyroid tumors. JNCI 39: 303–309PubMedGoogle Scholar
  10. Kauffman SL (1981) Histogenesis of the papillary Clara cell adenoma. Am J Pathol 103: 174–180PubMedGoogle Scholar
  11. Kociba RJ, McCollister SB, Park C, Torkelson TR, Gehring RI (1974) 1,4-Dioxane. I. Results of a 2-year ingestion study in rats. Toxicol Appl Pharmacol 30: 275–286Google Scholar
  12. Kociba RJ, Keyes DG, Beyer JE, Carreon RM, Wade CE, Dittenber DA, Kalnins RP, Frauson LE, Park CN, Barnard SD, Hummel RA, Humiston CG (1978) Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Toxicol Appl Pharmacol 46: 279–303PubMedCrossRefGoogle Scholar
  13. Kroes R, Garbis-Berkvens JM, de Vries T, van Nesselrooy HJ (1981) Histopathological profile of a Wistar rat stock including a survey of the literature. J Gerontol 36: 259–279Google Scholar
  14. Kuschner M, Laskin S (1970) Pulmonary epithelial tumors and tumor-like proliferations in the rat. In: Nettesheim P, Hanna MG Jr, Deatherage JW (eds) Morphology of experimental respiratory carcinogenesis, AEC Symposium Series 21 USAEC, Oak Ridge, pp 202–226Google Scholar
  15. Lieber M, Smith B, Szakal A, Nelson-Rees W, Todaro G (1976) A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int J Cancer 17: 62–70PubMedCrossRefGoogle Scholar
  16. Mac Kenzie WF, Garner FM (1973) Comparison of neoplasms in six sources of rats. JNCI 50: 1243–1257Google Scholar
  17. Maekawa A, Odashima S (1975) Spontaneous tumors in ACI/N rats. JNCI 55: 1437–1445PubMedGoogle Scholar
  18. Moulton JE, von Tscharner C, Schneider R (1981) Classification of lung carcinomas in the dog and cat. Vet Pathol 18: 513–528PubMedGoogle Scholar
  19. Prejean JD, Peckham JC, Casey AE, Griswold DP, Weisburger EK, Weisburger JH (1973) Spontaneous tumors in Sprague-Dawley rats and Swiss mice. Cancer Res 33: 2768–2773PubMedGoogle Scholar
  20. Radomski JL, Deichmann WB, MacDonald WE, Glass EM (1965) Synergism among oral carcinogens. Toxicol Appl Pharmacol 7: 652–656PubMedCrossRefGoogle Scholar
  21. Reznik G (1981) Unusual sites of lung tumor metastases in B6C3F1 mice and F344 rats. Anticancer Res 1: 159–162PubMedGoogle Scholar
  22. Reznik-Schuller HM, Reznik G (1982) Morphology of spontaneous and induced tumors in the bronchiolo-alveolar region of F344 rats. Anticancer Res 2: 53–57PubMedGoogle Scholar
  23. Reznik-Schuller HM, Hague BR Jr, Creasia DA (1981) Ultrastructure of pulmonary tumors induced in rats by Nnitrosomethylurethane. J Toxicol Environ Health 8: 501–506PubMedCrossRefGoogle Scholar
  24. Ross MH, Bras G (1965) Tumor incidence patterns and nutrition in the rat. J Nutr 87: 245–260PubMedGoogle Scholar
  25. Sass B, Rabstein LS, Madison R, Nims RM, Peters RL, Kelloff GJ (1975) Incidence of spontaneous neoplasms in F344 rats throughout the natural life span. JNCI 54: 1449–1456PubMedGoogle Scholar
  26. Schraufnagel D, Peloquin A, Paré JA, Wang NS (1982) Differentiating bronchioloalveolar carcinoma from adenocarcinoma. Am Rev Respir Dis 125: 74–79PubMedGoogle Scholar
  27. Singh G, Katyal SL, Torikata C (1981) Carcinoma of type II pneumocytes. Am J Pathol 102: 195–208PubMedGoogle Scholar
  28. Torkelson TR, Leong BKJ, Kociba RJ, Richter WA, Gehring PJ (1974) 1,4-Dioxane. H. Results of a 2-year inhalation study in rats. Toxicol Appl Pharmacol 30: 287–298Google Scholar
  29. WHO (1982) Histological typing of lung tumors. Neoplasma 29: 111–123Google Scholar
  30. Yang YH, Grice HC (1965) Mucinous bronchiolar carcinoma of the rat lung: a case report. Can J Comp Med 29: 15–17PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Gary A. Boorman

There are no affiliations available

Personalised recommendations