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Reversible Blocking of Amino and Carboxyl Groups

  • Miklos Bodanszky
Part of the Reactivity and Structure Concepts in Organic Chemistry book series (REACTIVITY, volume 16)

Abstract

In the preparation of even the smallest peptide, it becomes obvious that certain functional groups must be blocked. If amino acid H2N—CHR—COOH (A) has to be coupled with amino acid H2N—CHR’—COOH (B) to produce the dipeptide H2N—CHR—CO—NH—CHR’—COOH (AB), then, in order to acylate the amino group of the amino-component (B), we have to activate the carboxyl group of the carboxyl-component (A).

Keywords

Ethyl Ester Peptide Synthesis Catalytic Hydrogenation Liquid Ammonia Butyl Ester 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • Miklos Bodanszky
    • 1
  1. 1.Department of ChemistryCase Western Reserve UniversityClevelandUSA

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