Pituitary Tumors Induced by Estrogen, Rat

  • R. Yoshiyuki Osamura
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


As early as 1 month after intramuscular administration of estrogen (Teikokuzoki Co., Ltd.) at the rate of 5 mg/rat/month, the pituitary gland becomes hyperplastic. At this stage, the pituitary gland is enlarged to 2–3 times its normal size and is usually white to tan. Six months after the start of the estrogen injections the gland is tumorous, markedly congested, and enlarged up to tenfold. The tumor mass is well encapsulated and does not invade the adjacent tissue. The intermediate lobe is difficult to distinguish at this stage.


Pituitary Gland Secretory Granule Intermediate Lobe Growth Hormone Cell Estrogen Injection 
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© Springer-Verlag Berlin Heidelberg 1983

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  • R. Yoshiyuki Osamura

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