Pituitary Tumors Induced by Estrogen, Rat

  • R. Yoshiyuki Osamura
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

As early as 1 month after intramuscular administration of estrogen (Teikokuzoki Co., Ltd.) at the rate of 5 mg/rat/month, the pituitary gland becomes hyperplastic. At this stage, the pituitary gland is enlarged to 2–3 times its normal size and is usually white to tan. Six months after the start of the estrogen injections the gland is tumorous, markedly congested, and enlarged up to tenfold. The tumor mass is well encapsulated and does not invade the adjacent tissue. The intermediate lobe is difficult to distinguish at this stage.

Keywords

Estrogen Adenoma Eter Prolactin Craniopharyngioma 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Furth J, Clifton K (1966) Experimental pituitary tumors. In: Harris GW, Donovan BT (eds) The pituitary gland. Butter-worths, London vol 2, pp 460–497Google Scholar
  2. Furth J, Nakane P, Pasteels JL (1976) Tumours of the pituitary gland. In: Turusov VS (ed) Pathology of tumours in laboratory animals. vol I Tumours of the rat. IARC Scientific Publ. 466, Lyon Part 2 pp 201–237Google Scholar
  3. Horvath E, Kovacs K, Singer W, Ezrin C, Kerenyi NA (1977) Acidophil stem cell adenoma of the human pituitary. Arch Pathol Lab Med 101: 594–599PubMedGoogle Scholar
  4. Nakane PK (1975) Recent progress in the peroxidase-labeled antibody method. Ann NY Acad Sci 254: 203–211PubMedCrossRefGoogle Scholar
  5. Osamura RY, Watanabe K (1976) Peroxidase-labeled antibody method: its principle and applications to endocrinology. Clin Endocrinol 24: 1074–1087Google Scholar
  6. Osamura RY, Watanabe K, Teramoto A, Hirakawa K, Kawano N, Morii S (1978) Male prolactin secreting pituitary adenomas in humans studied by peroxidase-labeled antibody method. Acta Endocrinol 88: 643–652PubMedGoogle Scholar
  7. Osamura RY, Komatsu N, Nakahashi E, Watanabe K (1980) Light and electron microscopical combined staining by immunohistochemical and enzyme histochemical methods using rat prolactin-secreting pituitary tumours. Histochem J 12: 371–379PubMedCrossRefGoogle Scholar
  8. Osamura RY, Komatsu N, Izumi S, Yoshimura S, Murakoshi M, Watanabe K (1981) Pre-embedding immunoelectron microscopy by peroxidase-labeled antibody method. Applications to endocrinology. Acta Histochem Cytochem 14: 383–390Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • R. Yoshiyuki Osamura

There are no affiliations available

Personalised recommendations