Adenoma and Carcinoma, Pars Distalis, Rat

  • William W. Carlton
  • Christian L. Gries
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Pituitary neoplasms vary greatly in size, from single or multiple microscopic foci to large masses that replace the whole gland, markedly enlarging it up to a diameter of 20 mm and a weight of 350 mg or more (Kovacs et al. 1977; Fig. 125). The tumors are generally well defined, spherical, circumscribed, soft, friable, and smooth, but they may have an irregular nodular surface and they are not encapsulated. Either they are solid, or they contain cavernous vessels with hemorrhages and congestion (Andersson 1969). The tumors are separated from the brain, but a few tumors invade the adjacent brain and meninges. Large tumors protrude from the sella and produce compression atrophy of the adjacent brain parenchyma (Wolfe et al. 1938; Ross et al. 1970; Kovacs et al. 1977). The cut surface is light brown to dark red depending on the vascularity of the neoplasm.


Chromophobe, basophil, and acidophil adenoma carcinoma 


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© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • William W. Carlton
  • Christian L. Gries

There are no affiliations available

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