Lipid Hyperplasia*, Adrenal Cortex, Rat

  • Frantisek Zak
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The adrenals are enlarged, the gland surface is smooth; on cross section the cortex appears to be markedly widened showing diffuse, pale-yellow or ivory-white discoloration. A two- to fourfold increase may occur in the adrenal weight (Malendowicz 1972 a).


Lipid adrenal hyperplasia adrenocortical lipid hyperplasia adrenocortical lipid transformation adrenal change due to adrenostatic drugs congenital lipoid adrenal hyperplasia 


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  1. Bentley PJ (1981) Endocrine pharmacology: Physiological basis and therapeutic applications. Cambridge University Press, CambridgeGoogle Scholar
  2. Camacho AM, Cash R, Brough AJ, Wilroy RS (1967) Inhibition of adrenal steroidogenesis by amino-glutethimide and the mechanism of action. JAMA 202: 114–120CrossRefGoogle Scholar
  3. Cash R, Brough AJ, Cohen MNP, Satoh PS (1967) Aminoglutethimide (Elipten-Ciba) as an inhibitor of adrenal steroidogenesis: mechanism of action and therapeutic trial. J Clin Endocrinol Metab 27: 1239–1248PubMedCrossRefGoogle Scholar
  4. Chart JJ, Sheppard H, Allen MJ, Bencze WL, Gaunt R (1958) New amphenone analogs as adrenocortical inhibitors. Experientia 14: 151–152PubMedCrossRefGoogle Scholar
  5. Cohen MP (1968) Aminoglutethimide inhibition of adrenal desmolase activity. Proc Soc Exp Biol Med 127: 1086–1090PubMedGoogle Scholar
  6. Dexter RN, Fishman LM, Ney RL, Liddle GW (1967) Inhibition of adrenal corticosteroid synthesis by aminoglutethimide: studies of the mechanism of action. J Clin Endocrinol Metab 27: 473–480PubMedCrossRefGoogle Scholar
  7. Givens JR, Coleman S, Britt L (1968) Anatomical changes produced in the human adrenal cortex by aminoglutethimide, Clin Res 16: 441Google Scholar
  8. Goldman AS (1967) Experimental congenital adrenocortical hyperplasia: persistent postnatal deficiency in activity of 3ßhydroxysteroid dehydrogenase produced in utero. J Clin Endocrinol Metab 27: 1041–1049PubMedCrossRefGoogle Scholar
  9. Goldman AS (1970a) Production of congenital lipoid adrenal hyperplasia in rats and inhibition of cholesterol side-chain cleavage. Endocrinology 86: 1245–1251PubMedCrossRefGoogle Scholar
  10. Goldman AS (1970 b) Experimental congenital lipoid adrenal hyperplasia: prevention of anatomic defects produced by aminoglutethimide. Endocrinology 87: 889–893PubMedCrossRefGoogle Scholar
  11. Hart MM, Straw JA (1971) Studies on the site of action of o,p’DDD in the dog adrenal cortex. Steroids 17: 559–574PubMedCrossRefGoogle Scholar
  12. Hart MM, Reagan RL, Adamson RH (1973) The effect of isomers of DDD on the ACTH-induced steroid output, histology and ultrastructurs of the dog adrenal cortex. Toxicol Appl Pharmacol 24: 101–113PubMedCrossRefGoogle Scholar
  13. Hertz R, Tulhier WW, Schricker JA, Dhyse FG, Hallman LF (1955) Studies on amphenone and related compounds. Recent Prog Horm Res 11: 119–147Google Scholar
  14. Huggins C, Morii S, Pataki J (1969) Selective destruction of adrenal cortex by pulse doses of derivatives of 12-methylbenz (a) anthracene. Proc Natl Acad Sci 62: 704–707PubMedCrossRefGoogle Scholar
  15. Hughes SW, Burley DM (1970) Aminoglutethimide: a “side effect” turned to therapeutic advantage. Postgrad Med J 46: 409–416CrossRefGoogle Scholar
  16. Hutter AM Jr, Kayhoe DE (1966) Adrenal cortical carcinoma. Results of treatment with o,p’-DDD in 138 patients. Am J Med 41: 581–592PubMedCrossRefGoogle Scholar
  17. Kaminsky N, Luse S, Hartroft P (1962) Ultrastructure of adrenal cortex of the dog during treatment with DDD. JNCI 29: 127–159PubMedGoogle Scholar
  18. Kovacs K, Blascheck JA, Yeghiayan E, Hatakeyama S, Gar-dell C (1971) Adrenocortical lipid hyperplasia induced in rats by aniline. Am J Pathol 62: 17–34PubMedGoogle Scholar
  19. Liddle GW, Hollifield JW, Slaton PE, Wilson HM (1976) Effects of various adrenal inhibitors in low-renin essential hypertension. J Steroid Biochem 7: 937–940PubMedCrossRefGoogle Scholar
  20. Malendowicz LK (1972 a) Karyometrical and histochemical studies of adult male rat adrenal cortex after treatment with aminoglutethimide. Endokrinologie 60: 60–74PubMedGoogle Scholar
  21. Malendowicz LK (1972b) Comparative studies on the effects of aminoglutethimide, metopirone, ACTH and hydrocortisone on the adrenal cortex of adult male rats. I. Karyometric studies. Virchows Arch (Cell Pathol)11: 55–65Google Scholar
  22. Malendowicz LK (1973) Comparative studies on the effects of aminoglutethimide, metopirone, ACTH and hydrocortisone on the adrenal cortex of adult male rats. II. Histological and histochemical studies. Endokrinologie 61: 75–93PubMedGoogle Scholar
  23. Marek J, Motlik K (1975) Ultrastructural changes of the adrenal cortex in Cushing’s syndrome treated with aminoglutethimide ( Elipten Ciba ). Virchows Arch (Cell Pathol) 18: 145–156Google Scholar
  24. Marek J, Motlik K (1978) Ultrastructure of acute adrenocortical damage due to aminoglutethimide ( Elipten Ciba) in rats. Virchows Arch (Cell Pathol) 27: 173–187Google Scholar
  25. Marek J, Thoenes W, Motlik K (1970) Lipoide Transformation der Mitochondrien in Nebennierenrindenzellen nach Aminoglutäthimid ( Elipten Ciba ). Virchows Arch (Cell Pathol) 6: 116–131Google Scholar
  26. Marek J, Pfeifer U, Motlik K (1971) Hypertrophie des glatten endoplasmatischen Reticulum in Nebennierenrinden-Zellen nach Aminoglutäthimid. Virchows Arch (Cell Pathol) 8: 36–41Google Scholar
  27. Motlik K, Pinsker P, Starka L, Hradec E (1973) Effects of aminoglutethimide ( Elipten Ciba), a steroid biosynthesis blocking agent, on adrenal glands in Cushing’s syndrome. Virchows Arch (Pathol Mat) 360: 11–26Google Scholar
  28. Nelson DH (1980) The adrenal cortex: Physiological function and disease, vol XVIII Major problems in internal medicine. Saunders, PhiladelphiaGoogle Scholar
  29. Neville AM, O’Hare MJ (1982) The human adrenal cortex. Springer, Berlin Heidelberg New YorkCrossRefGoogle Scholar
  30. Orth DN, Liddle GW (1971) Results of treatment in 108 patients with Cushing’s syndrome. N Engl J Med 285: 243–247PubMedCrossRefGoogle Scholar
  31. Powers JM, Hennigar GR, Grooms G, Nichols J (1974) Adrenal cortical degeneration and regeneration following administration of DDD. Am J Pathol 75: 181–194PubMedGoogle Scholar
  32. Prader A, Gurtner HP (1955) Das Syndrom des Pseudohermaphroditismus masculinus bei kongenitaler Nebennierenrinden-Hyperplasie ohne Androgenuberproduktion (adrenaler Pseudohermaphroditismus masculinus). Helv Paediatr Acta 10: 397–412PubMedGoogle Scholar
  33. Racela A Jr, Azarnoff D, Svoboda D (1969) Mitochondrial cavitation and hypertrophy in rat adrenal cortex due to aminoglutethimide. Lab Invest 21: 52–60PubMedGoogle Scholar
  34. Santen RJ, Henderson IC (1981) A comprehensive guide to the therapeutic use of aminoglutethimide, Pharmanual 2. Karger, BaselGoogle Scholar
  35. Santen RJ, Lipton A, Kendall J (1974) Successful medical adrenalectomy with aminoglutethimide. Role of altered drug metabolism. JAMA 230: 1661–1665Google Scholar
  36. Schwarz W, Suchowsky GK (1963) Die Wirkung von Metopiron und Amphenon B auf die Nebennierenrinde der Ratte. Virchows Arch (Pathol Mat) 337: 270–278CrossRefGoogle Scholar
  37. Siebenmann RE (1957) Die kongenitale Lipoidhyperplasie der Nebennierenrinde mit Nebennierenrinde-Insuffizienz. Schweiz Z Allg Pathol (Basel) 20: 77–84CrossRefGoogle Scholar
  38. Smilo RP, Earl JM, Forsham PH (1967) Suppression of tumorous adrenal hyperfunction by aminoglutethimide. Metabolism 16: 374–377PubMedCrossRefGoogle Scholar
  39. Starka L, Motlik K (1971) The influence of injected aminoglutethimide on the morphology of rat adrenal cortex and adrenal metabolism of progesterone. Endokrinologie 58: 75–86PubMedGoogle Scholar
  40. Szabo S, Kovacs K, Horvath E, Szabo D, Huttner I, Garg BD, Tuchweber B (1977) Thioguanine-induced adrenocortical necrosis and its prevention by hypophysectomy in the rat. Exp Mol Pathol 26: 155–168PubMedCrossRefGoogle Scholar
  41. Volk TL, Scarpelli DG (1964) Alterations of fine structure of the rat adrenal cortex after the administration of Triparanol. Lab Invest 13: 1205–1214PubMedGoogle Scholar
  42. Yarrington JT, Huffman KW, Gibson JP (1981) Adrenocortical degeneration in dogs, monkeys and rats treated with a(1,4-dioxiodo-3-methylquinoxalin-2-y1)-N-methylnitrone ( DMNM ). Toxicol Lett 8: 229–234Google Scholar

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© Springer-Verlag Berlin Heidelberg 1983

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  • Frantisek Zak

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