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Nebenschilddrüsen und Vitamin-D- Stoffwechsel

  • R.-D. Hesch
  • H.-P. Krohn

Zusammenfassung

Die Nebenschilddrüsen hat als erster wahrscheinslich Owen 1850 bei der Sektion eines Rhinozeros im Londoner Zoo beschrieben [1]. Danach haben Remak [2], Virchow [3] und Sandström [4] 1880 über die Nebenschilddrüsen publiziert, letzterer beschrieb sie bei zahlreichen Spezies von Säugetieren und beim Menschen. Der Name Nebenschilddrüsen wurde wahrscheinhch erstmals von Vassale u. Generale [5] gebraucht. Der Zusammenhang zwischen Nebenschilddrüsenfunktion und Tetanie wurde von Wölfer 1879 [6] und von Weiss 1880 [7] erkannt und von Vassale u. Generale 1896 weiter belegt [8]. Der Zusammenhang zwischen Nebenschilddrüsenfunktion und der von v. Reckhnghausen beschriebenen Knochenveränderung wurde 1903 von Ashkenazy in Königsberg vermutet [9] und führte zu dem langen wissenschafthchen Streit zwischen Erdheim [10] und Mandl [11]. Erdheim vermutete eine Nebenschilddrüsenüberfunktion sekundär zu den Knochenveränderungen, während Mandl eine Überfunktion der Nebenschilddrüsen als Ursache für die Knochenerkrankung verantworthch machte, womit ihm das Verdienst der korrekten Erstbeschreibung der ossären Symptomatik bei Hyperparathyreoidismus zukommt.

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Literatur

  1. 1.
    Owen R (1852) On the anatomy of the Indian rhinoceros. Trans Zool Soc London 4/31:Art 111Google Scholar
  2. 2.
    Remak R (1851, 1858) Untersuchungen über die Entwicklung des Wirbeltieres. Berhn, Reimer 25:194 und Berlin, 191Google Scholar
  3. 3.
    Virchow R (1863–1867) In: Die krankhaften Geschwülste, Bd 3. Berlin, Hirschwald, S 13Google Scholar
  4. 4.
    Sandström J (1880) Om en ny körtel hos mennisken och artskilhga däggdjur (in schwedisch). Upsala Laekarefoeren Föerh 15:441Google Scholar
  5. 5.
    Vassale G, Generale F (1896) SugH effetti dell’ estirpazione delle ghandole para tiroidee. Riv PatolNerv Ment 1:95Google Scholar
  6. 6.
    Wölfer A (1880) Über die Entwicklung und den Bau der Schilddrüse mit Rücksicht auf die Entwicklung der Kröpfe. BerlinGoogle Scholar
  7. 7.
    Weiss N (1880) Über Tetanie. Volksmann Samml Khn Vortr Inn Med 7: Serie 189 1696Google Scholar
  8. 8.
    Vassale G, Generale F (1896) Sugli effetti dell’ estirpazione delle ghiandole paratiroidee. Riv PatolNerv Ment 1:95Google Scholar
  9. 9.
    Askanazy M (1903) Über Ostitis deformans ohne osteoides Gewebe. Arb Pathol Anat Inst Tuebingen 4:398–442Google Scholar
  10. 10.
    Erdheim J (1907) Über Epithelkörperchenbefunde bei Osteomalazie. Beitr. Akad Wiss Wien Math Naturwiss Kl Abt III 116:311Google Scholar
  11. 11.
    Mandl J (1925) Therapeutischer Versuch bei einem Fall von Osteitis fibrosa generalisata mittels Exstirpation eines Epithelkörperchentumors. Zentralbl Chir 53:260–264Google Scholar
  12. 12.
    Hanson AM (1923) An aUmentary study of the parathyroid glands of cattle. Mil Surg 52:280–284Google Scholar
  13. 13.
    Collip JB, Clarke EP, Scott JW (1925) The effect of a parathyroid hormone on normal animals. J Biol Chem 63:439Google Scholar
  14. 14.
    McLean FC, Hasting AB (1935) Clinical estimation and significance of calcium ion concentrations in the blood, Am J Med Sei 189:601CrossRefGoogle Scholar
  15. 15.
    Martin E, Bourdillon J (1940) Un cas de tétanie idiopathique chronique. Rev Med Suisse Romande 60:1166–77Google Scholar
  16. 16.
    Albright F, Burnett CH, Smith PH, Parson W (1942) Pseudohypoparathyroidism, an example of seabright-bantam syndrome. Endocrinology 30:922Google Scholar
  17. 17.
    Rasmussen H, Sze Y, Young R (1964) Further studies on the isolation and characterization of parathyroid polypeptides. J Biol Chem 239:2852–2857PubMedGoogle Scholar
  18. 18.
    Potts JT Jr, Aurbach GD, Sherwood LM (1966) Parathyroid hormone: Chemical properties and structural requirements for biological and immunological activity. Recent Prog Horm Res 22:101–132Google Scholar
  19. 19.
    Keutmann HT, Sauer MM, Boehnert M, Hendry GN, O’Riordan JLH (1978) Application of biosynthetic labelling to structural analysis of human parathyroid hormone. US Endocrine Society, 60 Annual Meeting, Miami (Poster Session 477)Google Scholar
  20. 20.
    Berson SA, Yalow RS, Aurbach GD, Potts JT Jr (1963) Immunoassay of bovine and human parathyroid hormone. Proc Natl Acad Sei USA 49:613–617CrossRefGoogle Scholar
  21. 21.
    Chase LR, Aurbach GD (1967) Parathyroid function and the renal excretion of 3’,5’- adenylic acid. Proc Natl Acad Sei USA 58:518CrossRefGoogle Scholar
  22. 22.
    Curtis GM (1930) The blood supply of the human parathyroids. Surg Gynecol Obstet 51:805Google Scholar
  23. 23.
    Altenähr E (1971) Electron microscopical evidence for innervafion of chief cells in human parathyroid gland. Experientia 27:1077PubMedCrossRefGoogle Scholar
  24. 24.
    Castleman B, Mallory TB (1935) The pathology of the parathyroid gland in hyperparathyroidism. A study of 25 cases. Am J Pathol 11:1PubMedGoogle Scholar
  25. 25.
    Rother P (1969) Uber Vorkommen und Funktion der oxyphilen Welsschen Zellen in Glandulae parathyreoidea. Z Mikrosk Anat Forsch 79:553Google Scholar
  26. 26.
    Christie AC (1967) The parathyroid oxyphil cells. J Clin Pathol 20:591CrossRefGoogle Scholar
  27. 27.
    Thiele J, Ries P, Georgii A (1975) Spezielle und funktionelle Pathomorphologie der Epithelkörperchen in einem unausgewählten Obduktionsgut. Virchows Arch [Pathol Anat] 376:195–208CrossRefGoogle Scholar
  28. 28.
    Paloyan E, Lawrence AM, Straus FH (1973) Hyperparathyroidism. Grune & Stratton, New York LondonGoogle Scholar
  29. 29.
    Habener JF, Kemper BW, Rieh A, Potts JT Jr (1977) Biosynthesis of parathyroid hormone. Recent Prog Horm Res 33:249–308Google Scholar
  30. 30.
    Habener JF, Kemper BW, Rich A, Potts JT Jr (1977) Biosynthesis of parathyroid hormone. Recent Prog Horm Res 33:249–308Google Scholar
  31. 31.
    MacGregor RR, Hamilton JW, Cohn DV (1975) The by-pass of tissue hormone stores during the secretion of newly synthesized parathyroid hormone. Endocrinology 97:178–188PubMedCrossRefGoogle Scholar
  32. 32.
    Möhr H, Hesch RD, Mcintosh CHS, Jüppner H (1980) Parathyroid hormone fragments in secretory granules of human parathyroid adenomas. Eur J Clin Invest 10:317–323PubMedCrossRefGoogle Scholar
  33. 33.
    Möhr H, Hesch RD (1980) Different handhng of parathyrin by basal- lateral and brush- border membranesofthebovinekidneycortex, BiochemJ188:649–655D’Amour P, Segre GV, Roth SI (1979) Analysis of parathyroid hormone and its fragments in rat tissues: Chemical identification and microscopical locahzation, J Chn Invest 63:89–98Google Scholar
  34. 34.
    Bialasiewicz AA, Jüppner H, Diehl V, Hesch RD (1979) Binding of parathyroid hormone to surface receptors of cultured B-lymphocytes, Biochem Biophys Acta 584:467–478PubMedCrossRefGoogle Scholar
  35. 35.
    Hesch RD, Hehrmann R (1979) Der primäre Hyperparathyreoidismus. Verh Dtsch Ges Inn Med 85:288–299Google Scholar
  36. 36.
    Rasmussen H (1974) Parathyroid hormone, calcitonin and the calciferols. In: Wilhams RH (ed) Textbook of endocrinology. Saunders, Philadelphia, pp 660–773Google Scholar
  37. 37.
    Moore EW (1970) Ionized calcium in normal serum, uhrafiltrates and whole blood determined by ion exchange electrodes, J Chn Invest 49:318–323CrossRefGoogle Scholar
  38. 38.
    Bronner F (1964) Dynamics in function of calcium. In: Comar LC, Bronner F (eds) Mineral metabolism, vol 2, part A. Academic Press, London New York, pp 342–447Google Scholar
  39. 39.
    Massry SG, Goldstein DA (1979) The search for uremic toxin (s) „X,“ „X“ = PTH. Clin Nephrol 11:181–189PubMedGoogle Scholar
  40. 40.
    Jüppner H, Möhr H, Hesch RD (1980) Antibodies and peptides blocking the parathyroid hormone receptor and the hormone dependent adenylate cyclase of renal plasma membranes. Sixth Int Congr of Endocrinology, Melbourne, abstracts. No. 268 p 343Google Scholar
  41. 41.
    Pritchard JJ (1956) The biochemistry and physiology of bone. Academic Press, London New York, pp 179–211Google Scholar
  42. 42.
    Peck WA (1978) The specialization of bone cells. In: Copp DN, Talmage RV (eds) Endocrinology of calcium metabohsm. Academic Press, London New York, pp 237–240Google Scholar
  43. 43.
    Herrmann-Erbe MPM, Gaillard PJ, Hekkelman JV (1978) Regulation of the response of embryonic bone to PTH and PTH fragments. A morphologic and biochemical study. In: Copp DN, Talmage RV (eds) Endocrinology of calcium metabohsm. Academic Press, London New York, pp 253–269Google Scholar
  44. 44.
    Jüppner H, Sräer J, Ardaillou R, Ebel H, Ruf M, Möhr H (1978) PTH receptors at different sites along the nephron. Acta Endocrinol [Suppl 215] (Copenh) 87:105–106Google Scholar
  45. 45.
    Nordin B, Peacock M (1969) The role of the kidney in regulation of plasma calcium. Lancet 11:1280–1283CrossRefGoogle Scholar
  46. 46.
    Munson PL (1955) Studies on the role of the parathyroid in calcium and phosphorus metabohsm. Ann NY Acad Sei 60:776–795CrossRefGoogle Scholar
  47. 47.
    Chase LR, Melson GL, Aurbach GD (1969) Pseudohypoparathyreoidism: Defective excretion of 3’,5’-AMP in response to parathyroid hormone. J Clin Invest 48:1832PubMedCrossRefGoogle Scholar
  48. 48.
    Aurbach GD, Potts J (1964) The parathyroids. Adv Metab Disord 1:45–93Google Scholar
  49. 49.
    Coleman EN (1965) Infantile hypercalcemia and cardiovascular lesions: Evidence, hypothesis and speculation. Arch Dis Child 40:535–540PubMedCrossRefGoogle Scholar
  50. 50.
    Glimcher MK, Krane SM (1968) Organization and structure of bone and mechanism of calcification. In: Gould BS, Ramachandran GN (eds) Treatise of collagen, part B. Academic Press, London New York, pp 68–241Google Scholar
  51. 51.
    Fleisch H, Russel RGG (1970) Pyrophosphate, polyphosphate and calcium homeostasis. In: Rasmussen H (ed) The international encyclopedia of pharmacology and therapeutics. Pergamon, LondonGoogle Scholar
  52. 52.
    Fleisch H, Bonjour JP, Morgan DB, Reynolds JJ, Schenk R, Smith R, Russel GG (1971) Diphosphorates. In: Taylor SW (ed) Endocrinology. Heinemann, London, p 430Google Scholar
  53. 53.
    Neumann VF (1970) TTie membrane regulation of ion fluxes in the skeleton. Fed Proc 29:1846Google Scholar
  54. 54.
    Wasserman RH, Corradino RA, Taylor AN, Morisey RL (1971) Intestinal calcium absorption vitamin D, adaption and the calcium-binding protein. In: Nichols G, Wasserman RH (eds) Cellular mechanisms for calcium transfer and homeostasis. Academic Press, London New York, p 294Google Scholar
  55. 55.
    Howard JE (1968) Reflections on calcium habits in man. Can Med Assoc J 99:41–48PubMedGoogle Scholar
  56. 56.
    Neer R, Berman M, Fisher L, Rosenberg LE (1967) Multicompartment analysis of calcium kinetics in normal adult males. J Clin Invest 46:1364–1379PubMedCrossRefGoogle Scholar
  57. 57.
    Potts JD, Deftos LJ (1974) Parthyroid hormone, calcitonin, vitamin D, bone and bone minimal metabohsm. In: Bondy PK, Rosenberg LE (eds) Duncan’s disease of metabohsm. Sounders, Philadelphia, p 1277Haussler MR, McCain TA (1977) Basic and chnical concepts related to vitamin D metabohsm and action. N Engl J Med 297:974–983Google Scholar
  58. 58.
    DeLuca HF, Schnoes HK (1976) Metabohsm and mechanism of action of vitamin D. Annu Rev Biochem 45:631–666PubMedCrossRefGoogle Scholar
  59. 59.
    Fraser DR, Kodicek E (1970) Unique biosynthesis by kidney of a biologically active vitamin D metabohte. Nature 228:764–766PubMedCrossRefGoogle Scholar
  60. 60.
    Norman SW, Henry H (1974) 1.25-Dihydroxycholecalciferol - A hormonally active form of vitamin D3. Recent Prog Horm Res 30:431–480Google Scholar
  61. 61.
    Pike JW, Tovernd S, Boass A (1977) Circulating 1-alpha,25-(OH)2-D during physiological states of calcium stress. In: Norman AW, Schaefer K, Coburn JN (eds) Vitamin D: Biochemical, chemical and chnical aspects related to calcium metabohsm. de Gruyter, pp 187–189Google Scholar
  62. 62.
    Hesch RD (1979) Diagnostische und therapeutische Empfehlungen für die renale Osteopathie. In: Hesch RD, Hehrmann R (Hrsg) Renale Osteopathie. Thieme, Stuttgart, S 113–119Google Scholar
  63. 63.
    David L, Anast CS (1974) Calcium metabohsm in newborn infants, J Chn Invest 54:287–296CrossRefGoogle Scholar
  64. 64.
    Tsang RC, Chen IW, Friedman MA, Chen IW (1973) Neonatal parathyroid function: Role of gestational age and postnatal age. J Pediatr 83:728–738Google Scholar
  65. 65.
    Schedewie HK, Odell WD, Fischer DA, Krutzik SR, Dodge M, Cousins L, Fisher WP (1979) Parathormon and perinatal calcium homeostasis. Pediatr Res 13:1–6PubMedCrossRefGoogle Scholar
  66. 66.
    Fanconi A (1975) Hypokalzamie beim Neugeborenen. Paediatr Fortbildungskurse Prax 41:184Google Scholar
  67. 67.
    Saville P, Kretchmer N (1960) Neonatal tetany, a report of 125 cases and review of the hterature. Biol Neonate 2:1CrossRefGoogle Scholar
  68. 68.
    Wolf H, Hesch RD (1975) Calcitonin in the newborn and influence of vitamin D3. In: Stembera ZK, Polacek K, Sabata V (eds) Perinatal medicine. Thieme, Stuttgart, Avice- num, Czechoslovak Medical Press Prague, pp 300–302Google Scholar
  69. 69.
    Tsang RC, Light IJ, Sutherland JM, Kleinmann LI (1973) Possible factors in neonatal hypocalcemia of prematurity. J Pediatr 82:423–429PubMedCrossRefGoogle Scholar
  70. 70.
    Tsang RC, Kleinman LI, Sutherland JM, Light IJ (1972) Hypocalcemie in enfants of diabetic mothers. J Pediatr 80:384–395PubMedCrossRefGoogle Scholar
  71. 71.
    Wagner G, Transbol I, Melchior JC (1964) Hyperparathyroidismus and pregnancy. Acta Endocrinol (Copenh) 47:549–564Google Scholar
  72. 72.
    Blizzard RM, Chee D, Davis W (1966) The incidence of parathyroid and other antibodies in the sere of patients with idiopathic hypoparathyroidism. Chn Exp Immunol 1:11Google Scholar
  73. 73.
    DiGeorge AM, Dacon C, Lischner HW, Arey JB (1966) Congenital absence of the thymus and its immunologic consequences. Concurrence with congenital hypoparathyroidism, Abstract Amer Ped Soc.Google Scholar
  74. 74.
    Brown DP, Tsang RC, Chen IW (1976) Oral calcium supplementation in premature and asphyxiated neonates. J Pediatr 89:973–977PubMedCrossRefGoogle Scholar
  75. 75.
    Fanconi A (1976) Störungen des Calcium- und Phosphatstoffwechsels, In: Harnack G A von (Hrsg) Therapie der Krankheiten des Kindesalters. Springer, Berhn Heidelberg New York, S 102Google Scholar
  76. 76.
    Salle BL, David L, Chopard JP, Grafmeyer DC, Renand H (1975) Prevention of early neonatal hypocalcemia in low birth weight infants with continuous calcium infusions. Pediatr Res 11:1180–1185CrossRefGoogle Scholar
  77. 77.
    Peden V (1960) True idiopathic hypoparathyroidism as a sex hnked recessive trait. Am J Hum Genet 12:323PubMedGoogle Scholar
  78. 78.
    Pronsky D, Kiamco RT, Waldstein S (1968) Famihal idiopathic hypoparathyroidism. J Clin Endocrinol Metab 18:61CrossRefGoogle Scholar
  79. 79.
    Spinner MW, Blizzard RM, Childs B (1968) Chnical and genetic heterogeneity in idiopathic Addison’s disease and hypoparathyroidism. J Clin Endocrinol Metab 28:795PubMedCrossRefGoogle Scholar
  80. 80.
    Dummermuth G (1965) Elektroencephalographie im Kindesalter. Thieme, StuttgartGoogle Scholar
  81. 81.
    Antebi L, Bouchard R, Guedeney J, Perles C, Weiss J (1966) Cardiomegaly due to hypocalcemia. Pediatrics 38:909–999Google Scholar
  82. 82.
    Aryenpur I, Farhondi A, Zangeneh F (1974) Congestive heart failure secondary to idiopathic hypoparathyroidism. Am J Dis Child 127:738–739Google Scholar
  83. 83.
    Courvoisier B, Berthoud E, Zahn DG, Grandjean A (1959) Donnés actuelles sur la physiologique clinique des parathyreoides. Helv Med Acta [Suppl] 38:26Google Scholar
  84. 84.
    Marshall RW (1976) Calcium fractions in plasma. In: Nordin BEC (ed) Metabolism. Churchill Livingstone, Edinburgh London New YorkGoogle Scholar
  85. 85.
    Kooh SW, Fraser D, DeLuca HF, Holick MF, Belsey RE, Clark MI, Murray TM (1975) Treatment of hypoparathyroidism and pseudohypoparathyroidism with metabohtes of vitamin D: Evidence for impaired conversion of 25-hydroxyvitamin D to 1,25-dihydroxy- vitamin D. N Engl J Med 293:840–844PubMedCrossRefGoogle Scholar
  86. 86.
    Kind HP, Handysides A, Kooh SW, Eraser D (1977) Vitamin D therapy in hypoparathyroidism and pseudo-hypoparathyroidism: Weight-related dosages for initiation of therapy and manitenance therapy. J Pediatr 91:1006–1010Google Scholar
  87. 87.
    Chesney RW, Horowitz SD, Kream BE, Eisman JA, Hong R, DeLuca HF (1977) Failure of conventional doses of la-25 dihydroxycholecalciferol to correct hypocalcemia in a girl with idiopathic hypoparathyroidism. N Engl J Med 297:1272–1275PubMedCrossRefGoogle Scholar
  88. 88.
    Fanconi A (1969) Hypoparathyreoidismus im Kindesalter. Erg Inn Med Kinderheilkd 28:54–119Google Scholar
  89. 89.
    Asherov J, Weinberger A, Pinkhas J (1977) Lack of response to vitamine D therapy in a patient with hypoparathyroidism under anticonvulsant drugs. Helv Paediatr Acta 32:369–373PubMedGoogle Scholar
  90. 90.
    Drezner M, Neelon FA, Lebowitz HE (1973) Pseudohypoparathyreoidismus type II. A possible defect in the reception of the cAMP signal. N Engl J Med 1056–1060Google Scholar
  91. 91.
    Stömag W, Fischer JA (1975) Pseudohypoparathyroidism. Disappearance of the resistance to parathyroid extract during treatment with vitamin D. Am J Med 59:140–144Google Scholar
  92. 92.
    Mannix HJ (1975) Primary hyperparathyroidism in children. Am J Surg 129:528–531PubMedCrossRefGoogle Scholar
  93. 93.
    Goldbloom RB, GilHs DA, Prasad M (1972) Hereditary parathyroid hyperplasie: A surgical emergency of early infancy. Pediatrics 49:514–522Google Scholar
  94. 94.
    Spiegel AM, Harrison HE, Marx SJ (1977) Neonatal primary hyperparathyroidism with autosomal dominant inheritance. J Pediatr 90:269–272PubMedCrossRefGoogle Scholar
  95. 95.
    Freyschmidt J, Hehrmann R (1978) Primärer Hyperparathyreoidismus als Differential- diagnose von schweren Skelettdestruktionen. Roentgenblaetter 31:495–502Google Scholar
  96. 96.
    Rhone DP (1975) Primary neonatal hyperparathyroidism. Report of a case and reviews of the literature. Am J Clin Pathol 64:488–499PubMedGoogle Scholar
  97. 97.
    Cushworth DC, Dent CE, Scriver CR (1972) Primary hyperparathyroidism and hyperaminoaciduria. Clin Chim Acta 41:355–361CrossRefGoogle Scholar
  98. 98.
    Bricker NS (1972) On the pathogenesis of the uremic state: An exposition of the „tradeoff“ hypothesis. N Engl J Med 286:1093–1098PubMedCrossRefGoogle Scholar
  99. 99.
    Swenson RS, Weisinger JL, Ruggeri JL, Reaven GM (1975) Evidence that parathyroid hormone is not required for phosphate homeostasis in renal failure. Metabohsm 24:199–204CrossRefGoogle Scholar
  100. 100.
    Tröhler U, Bonjour JP, Fleisch H (1976) Inorganic phosphate homeostasis Renal adaption to the dietary intake in intake and thyroparathyroidectomised rats. J Clin Invest 57:264–274PubMedCrossRefGoogle Scholar
  101. 101.
    Steele TH, Underwood JL (1978) Renal response to phosphorus deprivation in the isolated rat kidney. Kidney Int 13:124–129PubMedCrossRefGoogle Scholar
  102. 102.
    Llach F, Massry SG, Singer FR, Kurokawa K, Kaye JH, Coburn JW (1975) Skeletal resistance to endogenous parathyroid hormone in patients with early renal failure. A possible cause of secondary hyperparathyroidism. J Clin Endocrinol Metab 41:339–345PubMedCrossRefGoogle Scholar
  103. 103.
    Lihenfeldt-Toal H von, Hesch RD, Hüfner M, Mcintosh C (1974) Excretion of cyclic 3’,5’-adenosine monophosphate in renal insufficiency and primary hyperparathyroidism after stimulation with parathyroid hormone. Horm Metab Res 6:314–318CrossRefGoogle Scholar
  104. 104.
    Jüppner H, Bialasiewicz AA, Hesch RD (1978) Autoantibodies to parathyroid hormone receptors. Lancet II: 1222–1224CrossRefGoogle Scholar
  105. 105.
    Jüppner H, Hesch RD (1980) Inhibition of the parathyroid hormone dependent adenylate cyclase by receptor antibodies and low molecular peptides. Acta Endocrinol (Copenh) [Sppl] 124/94:122–123Google Scholar
  106. 106.
    Massry SG (1980) Parathyroid hormone and the uremic manifestations. Contrib Nephrol 20:84–91PubMedGoogle Scholar
  107. 107.
    Delling G, Lühmann H (1979) Morphologie und Histomorphometrie der renalen Osteopathie. In: Hesch RD, Hehrmann R (Hrsg) Renale Osteopathie. Thieme, Stuttgart, S 22–45Google Scholar
  108. 108.
    Brickman AS, Jowsey J, Sherrad DJ et al. (1975) In: Norman AW, Schaefer K, Grigoleit HG, Herrath D von, Rith E (eds) Vitamin D and problems related to uremic bone disease. De Gruyter, Berlin, pp 241–247Google Scholar
  109. 109.
    Deluca HF (1978) Vitamin D metabohsm and function. Arch Intern Med 138:836–845PubMedCrossRefGoogle Scholar
  110. 110.
    Norman AW, Schaefer K, Coburn JW, Deluca AF, Eraser D, Grigoleit HG, Herrath D von (1977) Vitamin D. Biochemical, chemical and chnical aspects related to calcium metabohsm. De Gruyter, Berhn New YorkGoogle Scholar
  111. 111.
    Eraser DR (1980) Regulation of the metabolism of vitamin D. Physiol Rev 60:551Google Scholar
  112. 112.
    Hesch RD, Henning HV, Gerlach W, Scheler F (1971) Früherkennung von Störungen der intestinalen Calciumabsorption bei Niereninsuffizienz. Khn Wochenschr 49:115CrossRefGoogle Scholar
  113. 113.
    Freyschmidt J (1979). In: Hesch RD, Hehrmann R (Hrsg) Renale Osteopathie. Thieme, Stuttgart, p 116Google Scholar
  114. 114.
    Moh H, Schmid F (1978) Radiologische Grundzüge der atypischen Rachitisformen. Z Kinderheilkd 80:469–483Google Scholar
  115. 115.
    World Health Organisation (1970) Vitamin D prophylaxe. Requirements of ascorbic acid, vitamin D, etc. Tech Rep Ser 452Google Scholar
  116. 116.
    Eraser D, Koch SW, Scriver CR (1978) Vitamin-D resistent rickets. In: Copp DN, Talmage RV (eds) Endocrinology of calcium metabohsm. Excerpta Medica, Amsterdam Oxford, pp 6–15Google Scholar
  117. 117.
    Eraser D, Koch SW, Scriver CR (1967) Hyperparathyroidism as the cause of hyperaminoaciduria and phosphaturia in human vitamin D deficiency. Pediatr Res 1:425–435CrossRefGoogle Scholar
  118. 118.
    Krohn HP, Brodehl J, Offner G, Liappis N, Weber HP (1974) Uber die Veränderung der Nierenfunktion bei der Vitamin D Mangel-Rachitis. Monatsschr Kinderheilkd 121:327–328Google Scholar
  119. 119.
    Sitrin M, Meredith S, Rosenberg IH (1979) Vitamin D deficiency and bone disease in gastrointestinal disorders. Arch Intern Med 138:886–888CrossRefGoogle Scholar
  120. 120.
    Prader A, Illig R, Heierh F (1961) Eine besondere Form der primären Vitamin D resistenten Rachitis mit Hypokalzämie und autosomal dominantem Erbgang: Die hereditäre Pseudomangelrachitis. Helv Paediatr Acta 16:452Google Scholar
  121. 121.
    Fräser D, Kooh SW, Kind HP, Holick MF, Tanaka Y, DeLuca HF (1973) Pathogenesis of hereditary vitamin D dependent rickets. An inborn error of vitamin D metabohsm involving defective conversion of 25-hydroxyvitamin D to 1 alpha 25 dihydroxyvitamin D. N Engl J Med 289:817PubMedCrossRefGoogle Scholar
  122. 122.
    Fanconi G, Girardet P (1951) Famihärer persistierender Phosphatdiabetes mit Vitamin D resistenter Rachitis, Helv Paediatr Acta 7:14–41Google Scholar
  123. 123.
    Krohn HP, Brandis M, Brodehl J, Offner G (1976) Vhamin D resistente Rachitis: Ergebnis einer zwölfmonatigen kombinierten Therapie mit Vitamin D und Phosphat. Monatsschr Kinderheilkd 124:417–418Google Scholar
  124. 124.
    Winters RW, Graham JB, Wilhams TF, McFalls VW, Burnett CH (1958) A genetic study of famihal hypophosphatemia and vitamin D resistant rickets with a review of the hterature. Medicine (Baltimore) 37:97CrossRefGoogle Scholar
  125. 125.
    Krohn HP (1980) Die famihäre Hypophosphatämie mit Vitamin D resistenter Rachitis. Habihtationsschrift, Universität, HannoverGoogle Scholar
  126. 126.
    McMair S, Stickler GB (1969) Growth in famihal hypophosphatemic vitamin D resistant rickets. N Engl J Med 281:511–516CrossRefGoogle Scholar
  127. 127.
    Scriver CR, Reade TM, DeLuca HF, Hamstra AJ (1978) Serum 1,25 dihydroxy-vitamin- D levels in normal subjects and in patients with hereditary rickets or bone disease. N Engl J Med 299:976–979PubMedCrossRefGoogle Scholar
  128. 128.
    Krohn HP, Brandis M, Brodehl J, Offner G (1974) Tubulärer Phosphattransport bei der Vitamin D resistenten Rachitis. Monatsschr Kinderheilkd 122:583–585PubMedGoogle Scholar
  129. 129.
    Krohn HP, Brandis M, Brodehl J, Offermann G (1976) The effect of hyperparathyroidism on tubular reabsorption of amino acids in vitamin D resistant rickets. Pediatr Res 10:875CrossRefGoogle Scholar
  130. 130.
    Glorieux FH, Scriver CR, Reade TM, Goldman A, Roseborough A (1972) Use of phosphate and vitamin D to prevent dwarfism and rickets in x-linked hypophosphatemia. N Engl J Med 287:481–487PubMedCrossRefGoogle Scholar
  131. 131.
    Hesch RD, Hehrmann R (1979) Renale Osteopathie. Thieme, StuttgartGoogle Scholar
  132. 132.
    Brodehl J (1978) The Fanconi Syndrome, In: Edelman CM Jr (ed) Pediatric Kidney disease. Little Brown, Boston, pp 955–986Google Scholar
  133. 133.
    Compston JE, Thompson RPH (1977) Intestinal absorption of 25-hydroxyvitamin D and osteomalacia in primary bihary cirrhosis. Lancet II: 721–724CrossRefGoogle Scholar
  134. 134.
    Wagonfeld JP, Nemchausky BA, Boh M (1976) Copmarison of vitamin D and 25 hydroxy vitamin D in the therapy of primary bihary cirrhosis. Lancet 11:391–394CrossRefGoogle Scholar
  135. 135.
    Hahn TJ, Birge SJ, Scharp CR, Avioh LV (1972) Phénobarbital induced alterations in vitamin D metabolism. J Clin Invest 91:741CrossRefGoogle Scholar
  136. 136.
    Schäfer U, Flury WH, Herrath D von, Kraft D, Schweingruber R (1972) Vitamin- D-Stoffwechsel und Antiepileptika. Schweiz Med Wochenschr 102:785Google Scholar
  137. 137.
    Brooks M, Bell NH, Love L etal. (1978) Vitamin-D-dependent rickets type II. N Engl J Med 298:996–999PubMedCrossRefGoogle Scholar
  138. 138.
    Salassa RM, Jowey J, Arnaud CD (1970) Hypophosphatemic osteomalecia associated with „nonendocrine“ tumors. N Engl J Med 283:65PubMedCrossRefGoogle Scholar
  139. 139.
    Royer P, Habib R, Mathieu H (1967) Nephrologie im Kindesalter. Thieme, Stuttgart, S 218Google Scholar
  140. 140.
    Palsan S, Garabedian M, Sorgniard R, Hohck MF, DeLuca HF (1975) 1,25 dihydroxyvi- tamin D3 and 1 a-hydroxyvitamin D3 in children. Pediatr Res 9:586–593Google Scholar
  141. 141.
    Chesney BW, Mazess RP, Rose P, Hamstra AJ, DeLuca HF (1980) Supranormal 25-hydroxyvitamin D and subnormal 1–25 dihydroxyvitamin D. Am J Dis Child 134:140–143PubMedGoogle Scholar
  142. 142.
    Stickler GB, Beabout JW, Riggs BL (1970) Chnical experience with 41 typical famihal hypophosphatemic patients and 2 atypical nonfamihal cases. Mayo Chn Proc 45:197Google Scholar
  143. 143.
    Moncrieff MW, Chance GW (1969) Nephrotoxic-effect of vitamin D therapy in vitamin D infractory rickets. Arch Dis Child 44:571–579PubMedCrossRefGoogle Scholar
  144. 144.
    Panier L, Kooh SW, Conen PF, Gibson AAM, Eraser D (1968) Renal function and histology after long-term vitamin D therapy of vitamin D infractory rickets. J Pediatr 73:833–844CrossRefGoogle Scholar
  145. 145.
    Walton RJ, Bijvoet OLM (1975) Nomogram for derivation of renal threshold phosphate concentration. Lancet 11:309–310CrossRefGoogle Scholar
  146. 146.
    Hesch RD (1978) Arbeitsgruppe Parathormon. Endokrinol Inf 3:109Google Scholar
  147. 147.
    Hesch RD, Offermann G, Wood G, Ziegler R (1980) Expertengruppe Parathormon und Calcitonin. Endokrinol 3:85–88Google Scholar
  148. 148.
    Lihenfeld-Toal H von, Hüfner M, Hesch RD, Mcintosh C (1974) The excretion of cAMP in renal insufficiency and primary hyperparathyroidism after stimulation with parathyroid hormone. Horm Metab Res 6:314–318CrossRefGoogle Scholar
  149. 149.
    McDonald KM (1972) Responsiveness of bone to parathyroid extract in sibhngs with pseudohypoparathyroidism. Metabolism 21:521–531PubMedCrossRefGoogle Scholar
  150. 150.
    Kaiser W, Ponsold W (1959) Über eine Möglichkeit zur Diagnose der relativen Neben- schilddrüseninsuffizienz durch Infusion von Äthylendiamintetraazetat (ÄDTA). Khn Wochenschr 37:1183–1185CrossRefGoogle Scholar
  151. 151.
    Parfitt AM (1967) Delayed recognition of postoperative hypoparathyroidism. Med J Aust 1:702–708PubMedGoogle Scholar
  152. 152.
    Hesch RD, Hehrmann R, Jüppner H (1978) Biokybernetische Aspekte der Parathormonsekretion unter Berücksichtigung des Vitamin-D Stoffwechsels. In: Oeff K, Schmidt HAE (Hrsg) Nuklearmedizin, Bd I.Medico, Berlin,S210–222Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • R.-D. Hesch
  • H.-P. Krohn

There are no affiliations available

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