Skip to main content

Klinische Krankheitsbilder bei Störungen der Bildung gastrointestinaler Hormone

  • Chapter
Endokrinologie des Kindes- und Jugendalters
  • 33 Accesses

Zusammenfassung

Unabhängig von den hormonproduzierenden Tumoren zeigen verschiedene gastrointestinale Hormone bei einigen Krankheitsbildern ein verändertes Verhalten, dessen pathologische Bedeutung bisher aber nur unvollkommen bekannt ist. In Tabelle 20.1 ist eine Übersicht gegeben (Übersicht bei [31,85]).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Arnold R, Fuchs K, Siewert R, Peiper HJ, Creutzfeldt W (1970) Zur Morphologie, Klinik, Diagnostik und Therapie des Zollinger-Ellison-Syndroms. Dtsch Med Wochenschr 99:607–616

    Article  Google Scholar 

  2. Becker V, Schneider HH (1968) Das Wermer-Syndrom: hereditäre endokrine Polyadenomatose. Dtsch Med Wochenschr 93:935–940

    Article  PubMed  CAS  Google Scholar 

  3. Besterman HS, Sarson DL, Johnston DI etal. (1978) Gut hormone profile in coeliac disease. Lancet I:785

    Google Scholar 

  4. Bleicher MA, Shandling B, Zingg W, Karl HWA, Track NS (1978) Increased serum immunoreactive gastrin levels in idiopathic hypertrophic stenosis. Gut 19:794

    Article  PubMed  CAS  Google Scholar 

  5. Bloom SR (1972) An enteroglucagon tumor. Gut 13:520

    Article  PubMed  CAS  Google Scholar 

  6. Bloom SR (ed) (1978) Gut hormones. Churchill Livingstone, Edinburgh

    Google Scholar 

  7. Bloom SR (1978) Vasoactive intestinal peptide, the major mediator of the WDHA (pancreatic cholera) syndrome: Value of measurement in diagnosis and treatment. Dig Dis 23:373–376

    Article  CAS  Google Scholar 

  8. Bloom SR (1978) VIP and watery diarrhoea VI. In: Bloom SR (ed) Gut hormones. Churclli Livingstone, Edinburgh, pp 583–588

    Google Scholar 

  9. Bloom SR, Polak JM (1976) VIP measurement in distinguishing Verner-Morrison syndrome and pseudo Verner Morrison syndrome. Clin Endocrinol (Oxf) 5:223–228

    Article  Google Scholar 

  10. Bloom SR, Polak JM (1980) Alimentary endocrine system. In: Sircus VU, Smith AN (eds) Sciendfic foundations of gastroenterology. Heinemann, London, pp 101–122

    Google Scholar 

  11. Bloom SR, Polak JM, Pearse AGE (1973) Vasoactive intestinal peptide and watery-diar-rhoea syndrome. Lancet II: 14–16

    Google Scholar 

  12. Bonfils S, Mignon M, Hervoir P, Letonturier P (1980) Long term follow-up in 92 cases of Zollinger-Ellison-Syndrome. Gastroenterology 78:1144

    Google Scholar 

  13. Br Med J (1978) Surgical approaches and drug treatment in the carcinoid syndrome. 1572–1573

    Google Scholar 

  14. Burcharth F, Stage JG, Stadil F, Jensen LJ, Fischerman K (1979) Localization of gastrinomas by transhepatic portal catheterization and gastrin assay. Gastroenterology 77:444–450

    PubMed  CAS  Google Scholar 

  15. Carney JA, Go VLW, Gordon H, Northcutt RC, Pearse AGE, Sheps SG (1980) Familial pheochromocytoma and islet cell tumour of the pancreas. Am J Med 68:515–521

    Article  PubMed  CAS  Google Scholar 

  16. Creutzfeldt W, Arnold R, Creutzfeldt C, Track NS (1975) Pathomorphologie, biochemical and diagnosdc aspects of gastrinomas (Zolhnger-Elhson syndrome). Hum Pathol 6:47–76

    Google Scholar 

  17. Creutzfeldt W, Ebert R, Arnold R, Frerichs H, Brown JC (1976) Gastric inhibitory polypepdde (GIP), gastrin, and insulin: Response to test meal in coeliac disease and after duo-deno-pancreatectomy. Diabetologia 12:279

    Google Scholar 

  18. DiMagno EP, Go VLW, Summerskill WHJ (1972) Impaired cholecystokinin-pancreozy- min-secretion, intraluminal dilution and maldigestion of fat in sprue. Gastroenterology 63:25

    PubMed  CAS  Google Scholar 

  19. Domschke S, Domschke W (1979) Gastrinbestimmung. In: Domschke W, Koch H (Hrsg) Diagnostik in der Gastroenterologie. Thieme, Stuttgart, S 322–323

    Google Scholar 

  20. Domschke S, Domschke W (1979) Bestimmung von vasoaktivem intestinalen Peptid (VIP). In: Domschke W, Koch H (Hrsg) Diagnostik in der Gastroenterologie. Thieme, Stuttgart, S 323–324

    Google Scholar 

  21. Dobroschke J, Schwemmle K, Feustel H, Steckenmesser R (1979) Erfahrungen in der Diagnostik und Therapie hormonaktiver Pankreastumoren. Med Welt 30:689–694

    PubMed  CAS  Google Scholar 

  22. Ebert R, Frerichs H, Creutzfeldt W (1976) Serum gastric inhibitory polypeptide (GIP) response in patients with maturity onset diabetes and in juvenile diabetes. Diabetologia 12:388

    Google Scholar 

  23. Ellison EH, Wilson SD (1964) The Zollinger-Ellison syndrome: Reappraisal and evaluation of 260 registered cases. Ann Surg 160:512–528

    Article  PubMed  CAS  Google Scholar 

  24. Fahrenkrug J (1980) Vasoactive intestinal polypeptide. Clin Gastroenterol 9:633–643

    PubMed  CAS  Google Scholar 

  25. Femppel J, Domschke W (1979) Pathophysiologie gastrointestinaler Hormone. Intern Welt 6:208

    Google Scholar 

  26. Fox PS, Hoffmann JW, Wilson SD, DeCosse JJ (1974) Surgical management of the Zollin- ger-Ellison syndrome. Surg Clin North Am 54:395–407

    PubMed  CAS  Google Scholar 

  27. Frerichs H, Track NS (1974) Pharmacotherapy of hormone-secreting tumours. Clin Gastroenterol 3:721–732

    Google Scholar 

  28. Fritsch WP, Hausamen TU, Scholten T (1977) Gastrointestinale Hormone. I. Hormone der Gastringruppe. Z Gastroenterol 15:264

    Google Scholar 

  29. Gagel RF, Costanza ME, DeLellis RA etal. (1976) Streptozotocin-treated Verner-Morri- son syndrome. Arch Intern Med 136:1429–1435

    Article  PubMed  CAS  Google Scholar 

  30. Ganda OP, Weir GC, Soeldner JS etal. (1977) Somatostatinoma. A somatostatin-con- taining tumor of the endocrine pancreas. N Engl J Med 296:963–967

    Article  PubMed  CAS  Google Scholar 

  31. Gardner JD (1978) Plasma VIP in patients with watery diarrhea syndrome. Dig Dis 23:370–373

    CAS  Google Scholar 

  32. Giercksky KE, Halse J, Mathisen W, Gjone E, Flatmark A (1980) Endocrine tumors of the pancreas. Scand J Gastroenterol 15:129–135

    Article  PubMed  CAS  Google Scholar 

  33. Gillett DJ, Smith RC (1974) Treatment of the carcinoid syndrome by hemihepatectomy and radical excision of the primary lesion. Am J Surg 128:95–99

    Article  PubMed  CAS  Google Scholar 

  34. Glass GBJ (ed) Gastrointestinal hormones. Raven, New York

    Google Scholar 

  35. Graham-Smith DG (1974) Natural history and diagnosis of the carcinoid syndrome. Clin Gastroenterol 3:575–594

    Google Scholar 

  36. Gregory RA, Tracy HJ (1964) A note on the nature of the gastrin-like stimulant present in Zollinger-Ellison tumours. Gut 5:115–117

    Article  PubMed  CAS  Google Scholar 

  37. Hajdu SJ, Winawer SJ, Myers WPL (1974) Carcinoid tumors. A study of 204 cases. Am J Clin Pathol 61:521–528

    CAS  Google Scholar 

  38. Harvey RF, Dowsett L, Hartog M, Read AE (1973) A radioimmunoassay for cholecystoki-nin-pancreozymine. Lancet 11:826

    Article  Google Scholar 

  39. Holst JJ (1978) Glucagonomas. In: Bloom SR (ed) Gut hormones. Churchill Livingstone, Edinburgh

    Google Scholar 

  40. Holst JJ (1979) Gut endocrine tumor syndromes. Clin Endocrinol Metab 413–432

    Google Scholar 

  41. Holst JJ (1979) Possible entries to the diagnosis of a glucagon-producing tumour. Scand J Gastroenterol [Suppl 53] 14:53–56

    Google Scholar 

  42. Ingemannson S, Holst JJ, Larsson LI, Lunderquist A (1977) Localization of glucagonomas by catheterization of the pancreatic veins and with glucagon assay. Surg Gynecol Obstet 145:504–508

    Google Scholar 

  43. Isenberg JI, Walsh JH, Passaro E, Moore EW, Grossman MI (1972) Unusual effect of secretin on serum gastrin, serum calcium, and gastric acid secretion in a patient with suspected Zollinger-Ellison syndrome. Gastroenterology 62:626–631

    PubMed  CAS  Google Scholar 

  44. Isler P, Hedinger C (1953) Metastasierendes Dünndarmcarzinoid mit schweren, vorwiegend das rechte Herz betreffenden Klappenfehlern und Pulmonalstenose – ein eigenartiger Symptomenkomplex? Schweiz Med Wochenschr 83:4–7

    PubMed  CAS  Google Scholar 

  45. Jaffe BM, Condon S (1976) Prostaglandins E and F in endocrine diarrheagenic syndromes. Ann Surg 184:516–524

    CAS  Google Scholar 

  46. Jaffe BM, Kopen DF, DeSchryver-Kecskemeti K, Gingerich RL, Greider M (1977) Indo-methacin-responsive pancreatic cholera. N Engl J Med 297:817–821

    Article  PubMed  CAS  Google Scholar 

  47. Kahn CR, Levy AG, Gardner JD, Miller JV, Gordon P, Schein PS (1975) Pancreatic cholera: Beneficial effects of treatment with streptozotocin. N Engl J Med 292:941–945

    Article  PubMed  CAS  Google Scholar 

  48. Kather H, Simon B (1980) Gastrointesdnale Hormone in der Pathogenese der Fettsucht. Dtsch Med Wochenschr 105:143

    Article  PubMed  CAS  Google Scholar 

  49. Kidd GS, Donowitz M, O’Dorisio T, Cataland S, Newman F (1979) Mild chronic watery diarrhea-hypokalemia syndrome associated with pancreadc islet cell hyperplasia. Am J Med 66:883–888

    Article  CAS  Google Scholar 

  50. Klöppel G, Seifert G, Heitz P (1979) Endokrine Pankreastumoren. Morphologie und Syndrome. Dtsch Med Wochenschr 104:1571–1577

    Article  PubMed  Google Scholar 

  51. Kowlessar OD (1978) The carcinoid syndrome. In: Sleisinger MH, Fordtran JS (eds) Gastrointesdnal disease. Saunders, Philadelphia

    Google Scholar 

  52. Kreis GJ, Orci L, Conlon M etal. (1979) Somatostatinoma syndroma. Biochemical, morphological and clinical features. N Engl J Med 301:285–292

    Article  Google Scholar 

  53. Lamers CBHW, Froeling PGAM (1979) Clinical significance of hyperparathyroidism in familial multiple endocrine adenomatosis type I (MEA I). Am J Med 66:422–424

    Article  PubMed  CAS  Google Scholar 

  54. Larsson LI, Holst JJ, Kühl C etal. (1977) Pancreatic somatostatinoma. Clinical features and physiological implications. Lancet 1:666–668

    Article  PubMed  CAS  Google Scholar 

  55. Lembeck F (1953) 5-Hydroxytryptamine in a carcinoid tumour. Nature 172:910–911

    Article  CAS  Google Scholar 

  56. Lomsky R, Langer F, Vortel V (1967) Demonstration of glucagon in islet cell adenomas of the pancreas by immunofluorescent technique. Am J Clin Pathol 51:245–250

    Google Scholar 

  57. Low-Beer TS, Harvey RF, Davies ER, Read AE (1975) Abnormalities of serum cholecystokinin and gallbladder emptying in celiac disease. N Engl J Med 292:961

    Article  PubMed  CAS  Google Scholar 

  58. Lundqvist G, Krause U, Larsson LL etal. (1978) A pancreatic-polypeptide producing tumour associated with the WDHA syndrome. Scand J Gastroenterol 13:715–718

    Article  PubMed  CAS  Google Scholar 

  59. Mallinson CN, Bloom SR, Warin AP, Salmon PR, Cox B (1974) A glucagonoma syndrome. Lancet II: 1–4

    Google Scholar 

  60. Mallinson CN, Adrian TE, Hanley J, Bryant M, Bloom SR (1977) Metabolic and clinical responses in patients with pancreatic glucagonomas. Ir J Med Sci 146:3–7

    Google Scholar 

  61. Marks IN, Bank S, Louw JH (1967) Islet cell tumor of the pancreas with reversible watery diarrhea and achlorhydria. Gastroenterology 52:695–708

    PubMed  CAS  Google Scholar 

  62. Mason RA, Steane PA (1976) Carcinoid syndrome: Its relevance to the anaesthetist. Anaesthesia 31:228–242

    Google Scholar 

  63. McCarthy DM (1980) The place of surgery in the Zollinger-Ellison syndrome. N Engl J Med 302:1344–1347

    Article  PubMed  CAS  Google Scholar 

  64. McFarland RJ (1979) GI-hormones and gastrointesdnal disease. Clin Endocrinol 8/ 2:331–348

    Google Scholar 

  65. McGarran MH, Unger RH, Recant L, Polk HC, Kilo C, Levin M (1966) A glucagonsecreting alpha-cell carcinoma of the pancreas. N Engl J Med 274:1408–1413

    Article  Google Scholar 

  66. McGuigan JE (1978) The Zollinger-Ellison-syndrome. In: Sleisinger MH, Fordtran JS (eds) Gastrointestinal disease. Saunders, Philadelphia, pp 860–875

    Google Scholar 

  67. McGuigan JE, Wolfe MM (1980) Secretin injection test in the diagnosis of gastrinoma. Gastroenterology 79:1324–1331

    PubMed  CAS  Google Scholar 

  68. Melmon KL (1974) The endocrinologic manifestadons of the carcinoid tumor. In: Williams RH (ed) Textbook of endocrinology. Saunders, Philadelphia, pp 1084–1104

    Google Scholar 

  69. Modlin IM, Bloom SR, Mitchell SJ (1978) Experimental evidence for vasoactive intestinal peptide as the cause of the watery diarrhoea syndrome. Gastroenterology 75:1051–1054

    PubMed  CAS  Google Scholar 

  70. Morgan JG, Marks C, Hearn D (1974) Carcinoid tumors of the gastrointestinal tract. Ann Surg 180:720–727

    Article  PubMed  CAS  Google Scholar 

  71. Nathan DM, Daniels GH, Ridgway EC (1980) Gastrinoma and phaeochromocytoma: Is there a mixed multiple endocrine adenoma syndrome? Acta Endocrinol (Copenh) 93:91–93

    CAS  Google Scholar 

  72. De Nutte N, Somers G, Gepts W, Jacobs M, Pipeleers D (1978) Pancreatic hormone release in tumour-associated hypersomatostatinemia. Diabetologia 14:227

    Google Scholar 

  73. Oberndorfer S (1907) Karzinoide: Tumoren des Dünndarms. Frankfurt Z Pathol 1:426–429

    Google Scholar 

  74. Pearse AGE, Polak JM (1978) The diffuse neuroendocrine system and the APUD concept. In: Bloom SR (ed) Gut hormones. Churchill Livingstone, Edinburgh London, pp 33–39

    Google Scholar 

  75. Pearse AGE, Polak JM, Bloom SR (1977) The newer gut hormones: Cellular sources, physiology, pathology and clinical aspects. Gastroenterology 72:746–761

    Google Scholar 

  76. Peiper HJ, Creutzfeldt W (1975) Endokrine Tumoren des Gastrointestinaltraktes. Diagnostik und Therapie. Chirurg 46:194–203

    Google Scholar 

  77. Polak JM, Bloom SR, Adrian IB, Heitz P, Bryand MG, Pearse AGE (1976) Pancreatic polypeptide insulinomas gastroinomas VIPomas and glucagonomas. Lancet L 328–330

    Google Scholar 

  78. Powell D, Cannon D, Skrabanek P, Kirrane J (1978) The pathophysiology of substance P in man. In: Bloom SR (ed) Gut hormones. Churchill Livingstone, Edinburgh, pp 524–529

    Google Scholar 

  79. Richardson CT, Feldman M, McClelland R, Dickerman RM, Kumpuris D, Fordtran JS (1979) Effect of vagotomy in Zollinger-Ellison syndrome. Gastroenterology 77:682–686

    PubMed  CAS  Google Scholar 

  80. Said SI, Faloona GR (1975) Elevated plasma and tissue levels of vasoactive intestinal polypeptide in the watery-diarrhea syndrome due to pancreatic, bronchogenic and other tumors. N Engl J Med 293:155–160

    Article  PubMed  CAS  Google Scholar 

  81. Stadil F (1980) Gastrinomas. In: Glass GBJ (ed) Gastrointestinal hormones. Raven, New York, 729–739

    Google Scholar 

  82. Stadil F, Stage JG (1979) The Zollinger-Ellison syndrome. Clin Endocrinol Metab 433–446

    Google Scholar 

  83. Tilson MD (1974) Carcinoid syndrome. Surg Clin North Am 54:409–423

    CAS  Google Scholar 

  84. Verner JV, Morrison AB (1958) Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia. Am J Med 25:374–380

    Article  PubMed  CAS  Google Scholar 

  85. Verner JV, Morrison AB (1974) Non-B islet tumors and the syndrome of watery diarrhoea, hypokalemia and hypochlorhydria. Clin Gastroenterol 3:595–608

    Google Scholar 

  86. Walsh JH (1978) Gastrointestinal peptide hormones and other biologically active peptides. In: Sleisenger MH, Fordtran JS (eds) Gastrointestinal disease, 2nd edn. Saunders, Phila-delphia, pp 107–195

    Google Scholar 

  87. Walsh JH (1978) Pancreatic cholera and related syndromes. In: Sleisinger MH, Fordtran JS (eds) Gastrointestinal disease. Saunders, Philadelphia, pp 1496–1504

    Google Scholar 

  88. Welch JP, Malt RA (1977) Management of carcinoid tumors of the gastrointestinal tract. Surg Gynecol Obstet 145:223–227

    PubMed  CAS  Google Scholar 

  89. Wermer P (1954) Genetic aspects of adenomatosis of endocrine glands. Am J Med 16:363–371

    Article  PubMed  CAS  Google Scholar 

  90. Wermer P (1974) Multiple endocrine adenomatosis: Multiple hormone-producing tumours, a familial syndrome. Clin Gastroenterol 3:671–684

    Google Scholar 

  91. Zollinger RM, Ellison EH (1955) Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg 142:709–723

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Goebell, H., Eysselein, V. (1982). Klinische Krankheitsbilder bei Störungen der Bildung gastrointestinaler Hormone. In: Stolecke, H. (eds) Endokrinologie des Kindes- und Jugendalters. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96694-1_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-96694-1_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-96695-8

  • Online ISBN: 978-3-642-96694-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics