Liver Regeneration Following Hepatic Resection Without Portal Blood
Surgical resection of liver tissue rarely runs the risk of provoking hepatocellular failure. The vigorous capacity of the liver to regenerate requires a mass of only 15%–20% of the original liver to sustain life-supporting function (Pack et al. 1962; McDermott et al. 1963). Normally, portal blood is available for the liver remainder following hepatic resection and seems to be the main nutrient for promoting liver regeneration (Rous and Larimore 1920; Weinbren 1955). Extensive studies have been performed to elucidate the mechanism whereby portal blood influences regenerative response after hepatectomy (Weinbren 1959;Starzl et al. 1975). Several mechanisms have been discussed, such as a humoral factor originating in a resected hepatic parenchyma (Sigel 1969 ; Levi and Zeppa 1971), the supply of hepatotrophic factors from a gastrointestinal source (Starzl et al. 1975,1978; Bucher and Swaffield 1975; Broelsch et al. 1974) and/or increased hepatic blood flow and augmented sinusoidal pressure (Grindlay and Bollman 1952; Child et al. 1953).
KeywordsHepatic Resection Liver Regeneration Portal Blood Hepatic Regeneration Portacaval Shunt
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