Surface Redox Potential and Vitality of an Extracorporeal Liver During Hemoperfusion
Since 1963 when Eiseman et al. used extracorporeal pig liver hemoperfusion for the treatment of acute hepatic failure (Eiseman et al. 1965), many investigators have tried to find criteria for the vitality of the extracorporeally perfused liver. In 1978, Green et al. measured the surface and outflow redox potential of rabbit kidneys to determine successfully the degree of damage caused by warm ischemia (Green et al. 1978). We therefore examined the surface redox potential of pig livers which were perfused extracorporeally, and compared it with the ability of the livers to detoxify ammonia. We also determined the total concentration of free phenols as possible products of liver decay in the perfusate.
KeywordsAmmonia Level Liver Perfusion Warm Ischemia Rabbit Kidney Acute Hepatic Failure
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