Surface Redox Potential and Vitality of an Extracorporeal Liver During Hemoperfusion

  • B. R. Kim
  • K.-J. Gundermann
  • K. Kimura
  • U. Grünn
  • T. S. Lie

Abstract

Since 1963 when Eiseman et al. used extracorporeal pig liver hemoperfusion for the treatment of acute hepatic failure (Eiseman et al. 1965), many investigators have tried to find criteria for the vitality of the extracorporeally perfused liver. In 1978, Green et al. measured the surface and outflow redox potential of rabbit kidneys to determine successfully the degree of damage caused by warm ischemia (Green et al. 1978). We therefore examined the surface redox potential of pig livers which were perfused extracorporeally, and compared it with the ability of the livers to detoxify ammonia. We also determined the total concentration of free phenols as possible products of liver decay in the perfusate.

Keywords

Phenol Ischemia Titration Penicillin Travenol 

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References

  1. Eiseman B, Liem DS, Raffuci F (1965) Heterologous liver perfusion in treatment of hepatic failure. Ann Surg 162:329–345PubMedCrossRefGoogle Scholar
  2. Green RD, Halasz NA, Collins GM (1978) Effluent redox potential: a rapid method for assaying warm ischemic injury. J Surg Res 25:222–225PubMedCrossRefGoogle Scholar
  3. Lie TS (1971) Orthotope Allotransplantation der Schweineleber. Bruns Beitr Klin Chir 218:728–735PubMedGoogle Scholar
  4. Müting D, Keller HE, Kraus W (1970) Quantitative colorimetric determination of free phenols in serum and urine of healthy adults using modified diazoreactions. Clin Chim Acta 27:117–181CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • B. R. Kim
    • 1
  • K.-J. Gundermann
    • 1
  • K. Kimura
    • 1
  • U. Grünn
    • 1
  • T. S. Lie
    • 1
  1. 1.Surgical University ClinicsBonnGermany

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