Immobilized Hepatic Enzymes as a Tool in Extracorporeal Detoxification
Of the proteins, enzymes are one of the most important and specialized classes. They act as the essential catalyst of a wide number of chemical reactions linked to the intermediate metabolism of cells. In the last 10 years, the knowledge and technology of enzyme isolation have progressed significantly and a better understanding of the working mechanisms of enzymes has been achieved (Luisi 1979). Many kinds of enzymes have been widely used in the medical (Wolf and Rosenberger 1977), food (Reed 1975) and synthetic chemical industries (Jones et al. 1974).
KeywordsToxicity Albumin Urea Carbohydrate EDTA
Unable to display preview. Download preview PDF.
- Chibata I, Tosa T, Mori T (1977) Immobilised enzymes for therapeutic applications and for large-scale production of biologically active compounds. In: Chang TMS (ed) Biomedical applications of immobilized enzymes and proteins, vol 1. Plenum Press, New York, pp 257–280Google Scholar
- Habing WH, Pabst MJ, Jakoby WB (1974) Glutathionine-S-transferase. J Biol Chem 249:7130–7139Google Scholar
- Jones JB, Sih CJ, Perlman D (eds) (1974) Application of biochemical system in organic chemistry, vols 1, 2. Wiley, New YorkGoogle Scholar
- Mulder GJ (1979) Detoxification or toxification? Modification of the toxicity of foreign compounds by conjugation in the liver. TIBS 86–90Google Scholar
- Reed G (ed) (1975) Enzymes in food processing. Academic Press, New YorkGoogle Scholar
- Siu Chong ED, Chang TMS (1977) L-Asparaginase as a model for enzyme therapy of substrate-dependent tumors. In: Chang TMS (ed) Biomédical applications of immobilized enzymes and proteins, vol 1. pp 105–120Google Scholar
- Wolf M, Rosenberger K (1977) Enzyme therapy. Regent House, Los AngelesGoogle Scholar