Augmented Solute Reduction in Diseases Treated by Extracorporeal Detoxification Systems: X-Effect Hypothesis
As early as 20 years ago (Mito et al. 1960), changes in circulating blood cellular elements were noted during extracorporeal circulation, particularly at the onset. In these early studies with extracorporeal membrane devices, decreases in leukocytes in the first 15–30 min of perfusion were noted and related to changes in their body distribution. Increases mainly in the lung capillaries were noted with related pulmonary functional changes. Serum taken from an animal on extracorporeal circulation, injected into a healthy animal, gave decreases in circulatory polymorphs. A humoral factor was thus implicated in those changes seen with extracorporeal circulation.
KeywordsBile Acid Primary Biliary Cirrhosis Extracorporeal Circulation Anion Exchange Resin Membrane Plasma
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