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Augmented Solute Reduction in Diseases Treated by Extracorporeal Detoxification Systems: X-Effect Hypothesis

  • Yukihiko Nosé
  • Paul S. Malchesky
  • Yoshihiro Asanuma

Abstract

As early as 20 years ago (Mito et al. 1960), changes in circulating blood cellular elements were noted during extracorporeal circulation, particularly at the onset. In these early studies with extracorporeal membrane devices, decreases in leukocytes in the first 15–30 min of perfusion were noted and related to changes in their body distribution. Increases mainly in the lung capillaries were noted with related pulmonary functional changes. Serum taken from an animal on extracorporeal circulation, injected into a healthy animal, gave decreases in circulatory polymorphs. A humoral factor was thus implicated in those changes seen with extracorporeal circulation.

Keywords

Bile Acid Primary Biliary Cirrhosis Extracorporeal Circulation Anion Exchange Resin Membrane Plasma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Asanuma Y, Malchesky PS, Zawicki I, Smith JW, Carey WD, Ferguson DR, Hermann RE, Nosé Y (1980) Clinical hepatic support by on-line plasma treatment with multiple sorbents. Trans Am Soc Artif Intern Organs 26:400–405PubMedGoogle Scholar
  2. Hakin R, McCarthy J, Lowrie E (1980) Effect of dialyzer reuse on leukopenia, hypoxemia and total hemolytic complement system (THC). Trans Am Soc Artif Intern Organs 26:159–164Google Scholar
  3. Lockwood CM, Worlledge S, Nicholas A, Cotton C, Peters DK (1979) Reversal of impaired splenic function in patients with nephritis or vasculitis (or both) by plasma exchange. N Engl J Med 300:524PubMedCrossRefGoogle Scholar
  4. Malchesky PS, Asanuma Y, Nosé Y (1980) Complement removal by sorbents in membrane plasma-pheresis with on-line plasma treatment. Trans Am Soc Artif Intern Organs 26:541–545PubMedGoogle Scholar
  5. Malchesky PS, Zawicki I, Asanuma Y, Calabrese L, Nosé Y (1980) On-line separation of macro-molecules by membrane filtration with cryogelation. International Symposium on Plasma Exchange, Cologne, FRG, June 6–7. Schattauer, Stuttgart, pp 133–139Google Scholar
  6. Mito M, Nishimura A, Sumiyoshi S, Kawai M, Nosé Y, Kawamura T, Yoshimoto C (1960) On ex-tracorporeal circulation of membrane artificial organs (liver and kidney) (in Japanese). Sogoigaku 7:538Google Scholar
  7. Nosé Y, Malchesky PS, Asanuma Y, Smith JW, Carey WD, Ferguson DR, Hermann RE (1980) Procedures and methodology of hemoperfusion as hepatic assist. International Symposium on Hemoperfusion, Haifa, Israel, August 25–26, 1979Google Scholar
  8. Nusbacher J, Scher ML, MacPherson JL (1977) Plateletpheresis using the haemonetics Model 30 cell separator. Vox Sang 33:9PubMedCrossRefGoogle Scholar
  9. Samtleben W, Blumenstein M, Liebl L, Gurland HJ (1980) Membrane plasma separation for treatment of immunological mediated diseases. Trans Soc Artif Intern Organs 26:12–16Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • Yukihiko Nosé
    • 1
  • Paul S. Malchesky
    • 1
  • Yoshihiro Asanuma
    • 1
  1. 1.Department of Artificial OrgansCleveland ClinicClevelandUSA

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