Large-Pore Hemodialysis in Fulminant Hepatic Failure

  • P. Opolon


In 50% of cases of fulminant hepatitis, brain death occurs (Nusinovici et al. 1977). Therefore maintenance of cerebral function is one of the main goals of an extracorporeal liver assist. Previous work in this laboratory showed that hemodialysis with high permeability polyacrylonitrile membrane (AN 69, Rhone Poulenc, Paris, France) allowed neurological and electroencephalogram (EEG) enhancement in 60% of comatose animals after acute liver ischemia (Opolon et al. 1976 a). Comparative hemodialysis with low-permeability Cuprophan membrane was followed by faster neurological and EEG deterioration and shorter survival (Opolon et al. 1976 a). These results led to simultaneous development of: (a) an experimental program to investigate brain neurotransmitters and amino acid transfer under such conditions; (b) a clinical trial of AN 69 hemodialysis for the treatment of liver coma in patients with fulminant hepatitis. Preliminary results have been published (Opolon et al. 1976 b) and the experimental part of this work has also been completed and published (Bloch et al. 1978).


Brain Death Fulminant Hepatic Failure Fulminant Hepatitis Hepatic Coma Liver Coma 
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  1. Bloch P, Delorme ML, Rapin JR, Granger A, Boschat M, Opolon P (1978) Reversible modifications of brain neuro-transmitters in experimental acute hepatic coma. Surg Gynecol Obstet 146:551–558PubMedGoogle Scholar
  2. Denis J, Opolon P, Nusinovici V, Granger A, Darnis F (1978) Treatment of encephalopathy during fulminant hepatic failure by hemodialysis with high permeability membrane. Gut 19:787–793PubMedCrossRefGoogle Scholar
  3. Faguer P (1979) Recherches sur les facteurs métaboliques du coma hépatique aigu expérimental. Medical dissertation, University of ParisGoogle Scholar
  4. Nusinovici V, Crubille C, Opolon P, Touboul JP, Darnis F, Caroli J (1977) Hépatites fulminantes avec coma. Complications, évolution et pronostic. Revue de 137 cas. Gastroenterol Clin Biol 1:861–886PubMedGoogle Scholar
  5. Opolon P, Lavallard MC, Huguet C, Bidallier M, Granger A, Gallot D, Bloch P (1976a) Hemodialysis versus cross-hemodialysis in experimental liver coma. Surg Gynecol Obstet 142:845–854PubMedGoogle Scholar
  6. Opolon P, Rapin JR, Huguet C, Granger A, Delorme ML, Boschat M, Sausse A (1976 b) Hepatic failure coma (HFC) treated by polyacrylonitrile membrane (PAN) hemodialysis (HD). Trans Am Soc Artif Intern Organs 22:701–708PubMedGoogle Scholar
  7. Scotto J, Opolon P, Eteve J, Vergoz D, Thomas M, Caroli J (1973) Liver biopsy and prognosis in acute liver failure. Gut 14:927–933PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • P. Opolon
    • 1
  1. 1.CHU Saint-AntoineParisFrance

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