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Hemoperfusion, Exchange Transfusion, Cross Circulation, Liver Perfusion, Hormones and Immobilized Enzymes

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Artificial Liver Support

Abstract

The present artificial liver support systems are mostly aimed at the possibility of removing toxic substances and waste metabolites. However, the liver also carries out important metabolic and synthetic functions and it may be more reasonable to look at combined approaches of detoxification and supplementation. This paper summarizes our work in this area of research.

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References

  • Amano I, Kano H, Takahira H, Yamamoto Y, Itoh K, Iwatsuki S, Maeda K, Ohta K (1978) Hepatic assist system using bead-type charcoal. In: Chang TMS (ed) Artificial kidney, artificial liver, and artificial cells. Plenum, New York, p 89

    Google Scholar 

  • Chang TMS (1964) Semipermeable microcapsules. Science 146:524–525

    Article  PubMed  CAS  Google Scholar 

  • Chang TMS (1966) Semipermeable aqueous microcapsules (artificial cells): with emphasis on experiments in an extracorporeal shunt system. Trans Am Soc Artif Intern Organs 12:13–19

    PubMed  CAS  Google Scholar 

  • Chang TMS (1969) Removal of endogenous and exogenous toxins by a microencapsulated absorbent. Can J Physiol Pharmacol 47/12:1043–1045

    Article  PubMed  CAS  Google Scholar 

  • Chang TMS (1972) Hemoperfusion over microencapsulated adsorbent in a patient with hepatic coma. Lancet 2:1371–1372

    Article  PubMed  CAS  Google Scholar 

  • Chang TMS (1976) Hemoperfusion alone and in series with ultrafiltration or dialysis for uremia, poisoning and liver failure. Kidney Int 10:S305–S311

    Google Scholar 

  • Chang TMS (1977) Biomédical applications of immobilized enzymes and proteins, vols 1,2. Plenum, New York

    Google Scholar 

  • Chang TMS (to be published) Adsorbent hemoperfusion in blood detoxification. Trans Soc Artif Intern Organs

    Google Scholar 

  • Chang TMS, Lister C (1980) Analysis of possible toxins in hepatic coma including the removal of mercaptan by albumin-collodion charcoal. Int J Artif Organs 3:108–112

    PubMed  CAS  Google Scholar 

  • Chang TMS, Malouf C (1978) Artificial cells microencapsulated multienzyme system for converting urea and ammonia to amino acid using α-ketoglutarate and glucose as substrate. Trans Am Soc Artif Intern Organs 24:18–20

    PubMed  CAS  Google Scholar 

  • Chang TMS, Migchelsen M (1973) Characterization of possible ‚toxic‘ metabolites in uremia and hepatic coma based on the clearance spectrum for larger molecules by the ACAC microcapsule artificial kidney. Trans Am Soc Artif Intern Organs 19:314–319

    Article  PubMed  CAS  Google Scholar 

  • Chang TMS, Lister C, Chirito E, O’Keefe P, Resurreccion E (1978) Effects of hemoperfusion rate and time of initiation of ACAC charcoal hemoperfusion on the survival of fulminant hepatic failure rats. Trans Am Soc Artif Intern Organs 24:243–245

    PubMed  CAS  Google Scholar 

  • Chirito E, Reiter B, Lister C, Chang TMS (1977) Artificial liver: the effect of ACAC microencapsulated charcoal haemoperfusion on fulminant hepatic failure. Artif Organs 1:76–83

    Article  PubMed  CAS  Google Scholar 

  • Chirito E, Lister C, Chang TMS (1979) Biochemical, hematological and histological changes in a fulminant hepatic failure rat model for artificial liver assessment. Artif Organs J 3/1:42–46

    Article  CAS  Google Scholar 

  • Gazzard BG, Weston MY, Murray-Lyon IM, Flax H, Record CO, Portmann B, Langley PG, Dunlop EH, Mellon PJ, Ward MB, Williams R (1974) Charcoal haemoperfusion in the treatment of fulminant hepatic failure. Lancet 1:1301–1306

    Article  PubMed  CAS  Google Scholar 

  • Gelfand MC, Winchester JF, Knepshield JH, Cohan SL, Schreiner GE (1978) Biochemistral correlates of reversal of hepatic coma with coated charcoal hemoperfusion. Trans Am Soc Artif Intern Organs 24:239–242

    PubMed  CAS  Google Scholar 

  • Hughes R, Cochrane MAG, Thomson AD, Murray-Lyon IM, Williams R (1975) Plasma inhibition factor. In: Williams R, Murray-Lyon IM (eds) Artificial liver support. Pitman Medical, London, p 263

    Google Scholar 

  • Kaziuka EN, Chang TMS (1979) In-vitro assessment of the removal of phenols by ACAC hemoperfusion. Int J artif Organs 2/4:215–221

    PubMed  CAS  Google Scholar 

  • Krumlowsky FA, del Greco F, Nieferman M (1978) Prolonged hemoperfusion and hemodialysis in management of hepatic failure and hepatorenal syndrome. Trans Am Soc Artif Intern Organs 24: 235–238

    Google Scholar 

  • Mohsini K, Lister C, Chang TMS (to be published) The effects of homologous cross-circulation and in situ liver perfusion on galactosamine induced fulminant hepatic failure rats. Artif Organs J

    Google Scholar 

  • Odaka M, Tabata Y, Kobayaski H, Nomura Y, Soma H, Hirasawa H, Sata H (1978) Clinical experience of bead-shaped charcoal hemoperfusion in chronic renal failure and fulminant hepatic failure. In: Chang TMS (ed) Artificial kidney, artificial liver, and artificial cells. Plenum, New York, p 79

    Google Scholar 

  • Opolon P, Huguet C, Nusinovici V, Lavallard MC, Crubille C, Gallot P, Bloch P, Granger A (1975) Effects of middle molecules removal on encephalopathy during acute liver failure. Trans Eur Soc Artif Organs 2:228–231

    Google Scholar 

  • Plotz PH, Berk PD, Scharschmidt BF (1974) Removing substances from blood by affinity chromatography: (I) removing bilirubin and other albumin-bound substances from plasma and blood with albumin conjugated agarose beads. J Clin Invest 53:778–782

    Article  PubMed  CAS  Google Scholar 

  • Shu C-D, Chang TMS (1980) Tyrosinase immobilized within artificial cells for detoxification in liver failure: I. Preparation and in vivo studies. Int J Artif Organs 3:287–292

    PubMed  CAS  Google Scholar 

  • Silk DBA, Williams R (1978) Treatment of fulminant hepatic failure by charcoal hemoperfusion. In: Chang TMS (ed) Artificial kidney, artificial liver, and artificial cells. Plenum, New York, p 125

    Google Scholar 

  • Tabata Y, Chang TMS (to be published) Comparisons of six artificial liver support regimes in fulminant hepatic coma rats. Trans Am Soc Artif Intern Organs

    Google Scholar 

  • Ton HY, Hughes RD, Silk DBA, Williams R (1979) Albumin coated Amberlite XAD-7 resin for hemoperfusion in acute liver failure. Int J Artif Organs 3:20–24

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Artificial Cells and Organs Research Centre Faculty of Medicine, McGill University, 3655 Drummond St., H3G 1Y6, Montreal, P.Q., Canada

    Thomas Ming Swi Chang

Authors
  1. Thomas Ming Swi Chang
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Editor information

Editors and Affiliations

  1. Abteilung für Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Krankenhaus Oststadt, Podbielskistr. 380, 3000, Hannover 51, Germany

    Gorig Brunner

  2. Abteilung für Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Karl-Wiechert-Allee 9, 3000, Hannover 61, Germany

    Friedrich Werner Schmidt

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© 1981 Springer-Verlag Berlin Heidelberg

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Chang, T.M.S. (1981). Hemoperfusion, Exchange Transfusion, Cross Circulation, Liver Perfusion, Hormones and Immobilized Enzymes. In: Brunner, G., Schmidt, F.W. (eds) Artificial Liver Support. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96629-3_19

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  • DOI: https://doi.org/10.1007/978-3-642-96629-3_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-96631-6

  • Online ISBN: 978-3-642-96629-3

  • eBook Packages: Springer Book Archive

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