Hormone Losses by Charcoal Hemoperfusion

  • O. Bartels
  • M. Neidhardt
  • H. Schellberger


Clinical manifestations of hepatic coma in patients with either fulminant hepatic failure or cirrhosis result from an accumulation of toxic substances and from lack of substances which are necessary for cerebral function (Williams 1972). It seemed obvious that detoxification by charcoal hemoperfusion may aggravate deficiency of physiological substances, e.g., hormones responsible for augmented endocrine changes in hepatic coma (Bartels et al. 1977). Chang has demonstrated experimentally the effective removal of substances in the middle molecular weight range including polypeptides using hemoperfusion with the ACAC microcapsule (Chang and Migchelsen 1973). Therefore, we started in vitro and in vivo studies on the development of hemoperfusion through coated charcoal for the removal of hormones within the range of 300–6000 MW.


Thyroid Hormone Liver Failure Fulminant Hepatic Failure Hepatic Coma Artificial Liver Support 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • O. Bartels
    • 1
  • M. Neidhardt
    • 1
  • H. Schellberger
    • 1
  1. 1.Medizinische UniversitätsklinikErlangenGermany

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