Bilirubin Removal by Sorbent Hemoperfusion from Jaundiced Blood
Experimental and theoretical studies suggest the utilization of a biocompatible macro-porous resin (MR) for selective removal of protein-bound components, such as bilirubin, from the blood. The MR resin removed 70% of the unconjugated bilirubin (UCB) in both in vitro and in vivo hemoperfusion (HP) tests in 3-h runs.
A simulated computer model incorporating an HP column model with a 3-compartmental body model has been developed. The model is capable of predicting the effects of HP treatment on the bilirubin concentration in the plasma, liver and extravascular compartments. In the absence of pharmacokinetic data for infants, the intercompartmental rate constants were estimated from data for an adult. Various clinical situations of jaundiced newborns are simulated and discussed.
KeywordsBlood Flow Rate Exchange Transfusion Bilirubin Concentration Macroporous Resin Unconjugated Bilirubin
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