Advertisement

Bilirubin Removal by Sorbent Hemoperfusion from Jaundiced Blood

  • S. Sideman
  • L. Mor
  • L. S. Fishler
  • I. Thaler
  • J. M. Brandes

Abstract

Experimental and theoretical studies suggest the utilization of a biocompatible macro-porous resin (MR) for selective removal of protein-bound components, such as bilirubin, from the blood. The MR resin removed 70% of the unconjugated bilirubin (UCB) in both in vitro and in vivo hemoperfusion (HP) tests in 3-h runs.

A simulated computer model incorporating an HP column model with a 3-compartmental body model has been developed. The model is capable of predicting the effects of HP treatment on the bilirubin concentration in the plasma, liver and extravascular compartments. In the absence of pharmacokinetic data for infants, the intercompartmental rate constants were estimated from data for an adult. Various clinical situations of jaundiced newborns are simulated and discussed.

Keywords

Blood Flow Rate Exchange Transfusion Bilirubin Concentration Macroporous Resin Unconjugated Bilirubin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aylward TD, Schowengerdt CG, Bove K (1973) Experimental hyperbilirubinemia: Effect on glomerular filtration. J Surg Res 15:1–3PubMedCrossRefGoogle Scholar
  2. Berk PD (1977) A computer simulation study relating to the treatment of fulminant hepatic failure by hemoperfusion. Proc Soc Eng Bio Med 155:535–539Google Scholar
  3. Berk PD, Howe RB, Bloomer JR, Berlin ND (1969) Studies of bilirubin kinetics in normal adults. J Clin Invest 48:2176–2190PubMedCrossRefGoogle Scholar
  4. Brown AK (1976) Bilirubin metabolism in the fetus and newborn. In: Smith CA, Nelson NM (eds) The physiology of the newborn infant. Thomas, Springfield, p 312Google Scholar
  5. Fishier LS, Sideman S, Brandes JM (in press) A mathematical study of the removal of bilirubin by hemoperfusion from adults. Med Biol. Eng Comp. ModelingGoogle Scholar
  6. Lee KJ, Gartner LM, Eidelman AI, Ezhutthachan S (1977) Unconjugated hyperbilirubinaemia in very low birth weight infants. Clin Perinatol 4:305–320PubMedGoogle Scholar
  7. Mor L, Mor LA, Sideman S, Brandes JM (1980a) Time dependent packed bed adsorption of a chemically bound adsorbate. Chem Eng Sci 35:725CrossRefGoogle Scholar
  8. Mor LA, Sideman S, Mor L, Brandes JM (1980b) Analysis of hemoperfusion columns: Selective removal of protein-bound metabolites. In: Sideman S, Chang TMS (eds) Hemoperfusion: Kidney and liver supports and detoxification. Hemisphere, New YorkGoogle Scholar
  9. Sideman S, Mor L, Rousseau I, Brandes JM, Ben Arie D (1977) Removal of bilirubin from the blood of jaundiced infants. In: Kenedi RM, Courtney JM, Gaylor JDS, Gilchrist T (eds) Artificial organs. Macmillan, London, pp 413–424Google Scholar
  10. Sideman S, Hoffer E, Mor L, Brandes JM, Rousseau I, Better O, Ben Arie D, Lupovitch S (1978) Biocompatibility studies of hemoperfusion systems for liver and kidney support. In: Chang TMS (ed) Artificial kidney, artificial liver and artificial cells. Plenum, New York, pp 173–182Google Scholar
  11. Sideman S, Mor L, Brandes JM (1979) Removal of bilirubin by hemoperfusion with ion exchange resins. Trans Am Soc Artif Intern Organs 25:497–501PubMedCrossRefGoogle Scholar
  12. Sideman S, Mor L, Brandes JM (1980) Sorption of bilirubin by ion exchangerresins in vitro. Trans Amer. Soc. Artif. Intern. Organs 25:497Google Scholar
  13. Valaes T (1963) Bilirubin distribution and dynamics of bilirubin removal by exchange transfusion. Acta Paediatri [Suppl 149]: 1–117Google Scholar
  14. Weber AP, Schalm L (1962) Quantitative separation and determination of bilirubin and conjugated bilirubin in human serum. Clin Chem Acta 7:805–810CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • S. Sideman
    • 1
  • L. Mor
    • 1
  • L. S. Fishler
    • 2
  • I. Thaler
    • 1
  • J. M. Brandes
    • 1
  1. 1.Department of Chemical Engineering and School of MedicineTechnion-Israel Institute of TechnologyHaifaIsrael
  2. 2.Department of Chemical EngineeringOklahoma State UniversityStillwaterUSA

Personalised recommendations