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Mechanism of Liver Cell Destruction in Fulminant Hepatic Failure

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Abstract

The mechanism of hepatocellular death remains a challenging problem. It is well understood only when sudden interruption of cellular respiration, for instance by cyanide, results in instantaneous death without any morphologic alterations. Otherwise, cell death causes recognizable changes implying necrosis (Trump et al. 1974). It is then a step-like process of degeneration of the organelles. Therefore, the possibility of identifying these various steps offers one of the most promising avenues of basic research in hepatology to be applied to the management of acute and chronic liver disease.

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Author information

Authors and Affiliations

  1. Stratton Laboratory for the Study of Liver Diseases, Mount Sinai School of Medicine of the City University of New York, One Gustave L. Levy Place, New York, New York, 10029, USA

    Hans Popper

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  1. Hans Popper
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Editor information

Editors and Affiliations

  1. Abteilung für Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Krankenhaus Oststadt, Podbielskistr. 380, 3000, Hannover 51, Germany

    Gorig Brunner

  2. Abteilung für Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover, Karl-Wiechert-Allee 9, 3000, Hannover 61, Germany

    Friedrich Werner Schmidt

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© 1981 Springer-Verlag Berlin Heidelberg

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Popper, H. (1981). Mechanism of Liver Cell Destruction in Fulminant Hepatic Failure. In: Brunner, G., Schmidt, F.W. (eds) Artificial Liver Support. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96629-3_1

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  • DOI: https://doi.org/10.1007/978-3-642-96629-3_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-96631-6

  • Online ISBN: 978-3-642-96629-3

  • eBook Packages: Springer Book Archive

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