Abstract
Proerythroblasts, also called pronormoblasts or rubriblasts, are the earliest precursors of erythropoiesis. They do not yet contain any hemoglobin. Their size ranges from 15 to 22 µm. The dark basophil, frequently lightly shaded cytoplasm is characteristic. The nucleus reveals a dense, fine honeycombed chromatin structure. As a rule, several, up to 5, pale blue nucleoli are present, which are difficult to define, however, and disappear on further maturation of the cell. In conjunction with all erythropoietic cells, proerythroblasts tend to produce multinucleated forms, but less so than plasma cells. A light area in the cytoplasm near the nucleus is typical which appears as finely granular by phase contrast microscopy. Hemoglobinization also commences at the nucleus: at first there is a lighter perinuclear zone (cells 1, 3, 8, 9), that eventually occupies the whole cell and directly passes to the polychromatic forms (cells 7–10). Simultaneously, the nucleus undergoes a characteristic change in structure: the nucleoli disappear. The chromatin stroma becomes coarser and transforms to the typical erythroblast nucleus.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bessis, M.: Living blood cells and their ultrastructure. Berlin-Heidelberg-New York: Springer-Verlag 1973
Huhn, D., Stich, W.: Fine structure of blood and bone marrow. Munich: J.F. Lehmann 1969
Ruzicka, F.: Elektronenmikroskopische Hämatologie. Vienna-New York: Springer-Verlag 1976
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1979 Springer-Verlag Berlin-Heidelberg
About this chapter
Cite this chapter
Begemann, H., Rastetter, J. (1979). Blood and Bone Marrow. In: Atlas of Clinical Hematology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96527-2_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-96527-2_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-96529-6
Online ISBN: 978-3-642-96527-2
eBook Packages: Springer Book Archive