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Pathogenese der akuten gastroduodenalen Läsion („Streßulcus“)

  • W. Lorenz
  • H.-J. Reimann
  • M. Fischer
Conference paper
Part of the Interdisziplinäre Gastroenterologie book series (GASTROENTEROLOG)

Zusammenfassung

Nach Hensel [15] ist ein Stressor ein äußerer oder innerer Faktor, der langfristig kontinuierlich oder diskontinuierlich auf den Organismus einwirkt, wobei dieser mit Adaptaten reagiert, die dem Effekt des Stressors entgegenwirken. Dadurch kommt es zur Kompensation einer zunächst unter der Wirkung des Stressors abgewichenen physiologischen Größe (Abb. 1) [15]. Oft erfolgt die Kompensation nicht aperiodisch, sondern in Form einer gedämpften Schwingung. Diese wird durch das Ausmaß der sogenannten unspezifischen Begleitreaktionen im Vorgang der Adaptation entscheidend mitbestimmt.

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Literatur

  1. 1.
    Bonfils, S., Lambling, A.: Psychological factors and psychopharmacological actions in the restraint-induced gastric ulcer. In: Pathophysiology of peptic ulcer. Skoryna, St. C., Bockus, H. L. (eds.), p. 153. Philadelphia: Lippincott 1963Google Scholar
  2. 2.
    Braun, S.A., Samson, R.H., Norton, L., Eiseman, B.: Bile reflux in experimental stress ulcer. Surgery 73, 521 (1973)PubMedGoogle Scholar
  3. 3.
    Brodie, D.A., Hanson, H.M.: A study of the factors involved in the production of gastric ulcer by the restraint technic. Gastroenterology 38, 353 (1960)PubMedGoogle Scholar
  4. 4.
    Cooke, A. R.: Role of adrenocortical steroids in the regulation of gastric secretion. Gastroenterology 52, 272 (1967)PubMedGoogle Scholar
  5. 5.
    Desbaillets, L., Menguy, R.: Inhibition of gastric mucosa secretion by ACTH. Amer. J. dig. Dis. 12, 582(1967)PubMedCrossRefGoogle Scholar
  6. 6.
    Djahanguiri, B., Hemmati, S., Sadeghi, D., Firouzabadi, A.: The prevention of acute gastric ulcer in the rat by a-methyldopa. Med. Pharmacol. Exp.11, 421 (1967)Google Scholar
  7. 7.
    Emäs, S.: Gastric acid secretion in sympathectomized gastric fistula cats, before and after reserpine treatment, and in gastric fistula cats during guanethidine treatment. Acta physiol. scand. 60, 57 (1964)CrossRefGoogle Scholar
  8. 8.
    Feifel, G., Lorenz, W., Huhnd, A., Zboralski, B.: Die Bedeutung von Histamin bei der Pathogenese akuter Erosionen im Rattenmagen. Res. ges. exp. Med. 157, 206–207 (1972)CrossRefGoogle Scholar
  9. 9.
    Feifel, G.: Gastro-duodenale Ulzera und Erosionen. In: Chirurgie der Gegenwart, Bd. II, S. 1–84.1976Google Scholar
  10. 10.
    Fielding, L. P., Raute, M., Curwain, B. P.: Effect of salbumatol on acute gastric ulceration induced by indomethacin in the rat. Europ. surg. Res. 9,252–257 (1977)CrossRefGoogle Scholar
  11. 11.
    Fischer, M., Lorenz, W., Reimann, H.-J., Troidl, H., Rohde, H., Schwarz, B., Hamelmann, H.: Cimetidine prophylaxis of acute gastroduodenal lesions in patients at risk. Amsterdam: Excerpta Medica, pp. 280–289 (1978)Google Scholar
  12. 12.
    Gerard, A.: Histochemical studies of the fundic mucosa of the stomacid in dogs treated by ulcerogenic drugs. C.R. Soc. Biol. (Paris) 159, 1473 (1965)Google Scholar
  13. 13.
    Gottschalk, A.: Sialic acids: their molecular structure and biological function in mucoproteins. Bull. Soc. Chim. biol. (Paris) 42, 1387 (1960)Google Scholar
  14. 14.
    Guilbert, J., Bonnous, G., Gurd, F.N.: Role of the intestinal chyme in the pathogenesis of gastric ulceration following experimental hemorrhagic shock. J. Trauma 9, 723 (1969)PubMedCrossRefGoogle Scholar
  15. 15.
    Hensel, H.: Grundbegriffe und neuere Aspekte der physiologischen Adaptation. In: Kolloquien des Sonderforschungsbereiches Adaptation und Rehabilitation (SFB 122), Bd. II, S. 1–8.1974Google Scholar
  16. 16.
    Katz, D., Siegel, H.J.: Erosive gastritis and acute gastrointestinal mucosal lesions. Progr. Gastroent. 7, 67 (1968)Google Scholar
  17. 17.
    Kim, Y.S., Kerr, R., Lipkin, M.: Cell proliferation during the development of stress erosions in mouse stomach. Nature 215, 1180 (1967)PubMedCrossRefGoogle Scholar
  18. 18.
    Kirksey, C.Th., Moncrief, J.A., Pruitt, B.A., O’Neill, J.A.: Gastrointestinal complications in burns. Amer. J. Surg. 116, 627 (196)Google Scholar
  19. 19.
    Kusche, J., Richter, H., Schmidt, J., Hesterberg, R., Friedrich, A., Lorenz, W.: Diamine oxidase in rabbit small intestine: separation from a soluble monoamine oxidase, properties, and pathophysiological significance in intestinal ischemia. Agents and Actions 5, 431 (1975)PubMedCrossRefGoogle Scholar
  20. 20.
    Kusche, J., Stahlknecht, C.-D., Lorenz, W., Reichert, G., Richter, H.: Diamine oxidase activity and histamine release in dogs following acute mesenteric artery occlusion. Agents and Actions 7, 81–84 (1977)PubMedCrossRefGoogle Scholar
  21. 21.
    Kusche, J., Stahlknecht, C.-D., Lorenz, W., Jostarndt, L., Dietz, W.: Involvement of the histamine-diamine oxidase system in acute intestinal ischemia. Fed. Proc.37, 392 (1978)Google Scholar
  22. 22.
    Levine, R. J., Senay, E. C.: Histamine in the pathogenesis of stress ulcer in the rat. Amer. J. Physiol. 214, 892(1968)PubMedGoogle Scholar
  23. 23.
    Lorenz, W., Feifel, G.: Neue Gesichtspunkte zur Pathogenese des Streß- und Steroidulkus. Dtsch. med. Wschr. 95, 1848–1850 (1970)PubMedCrossRefGoogle Scholar
  24. 24.
    Lorenz, W., Benesch, L., Barth, H., Matejka, E., Meyer, R., Kusche, J., Hutzel, M., Werle, E.: Fluorometric assay of histamine in tissues and body fluids: Choice of the purification procedure and identification in the monogram range. Z. analyt. Chem. 252, 94–98 (1970)CrossRefGoogle Scholar
  25. 25.
    Lorenz, W., Barth, H., Kusche, J., Reimann, H.-J., Schmal, A., Matejka, E., Mathias, Ch., Hutzel, M., Werle, E.: Histamine in the pig. Determination, distribution, release and pharmacological actions. Europ. J. Pharmacol. 14, 155–175 (1971)CrossRefGoogle Scholar
  26. 26.
    Lorenz, W., Hell, E., Boeckl, O., Reimann, H.-J., Zimmermann, G., Seidel, W., Laszcz, M., Uhlig, R.: Hitamine release during orthotopic homologous liver transplantation in pigs. Europ. Surg. Res. 5, 11–20 (1973)CrossRefGoogle Scholar
  27. 27.
    Lorenz, W., Boeckl, O., Struck, E., Hell, E., Zimmermann, G., Reimann, H.-J., Tauber, R., Scheffer, B.: Significance and causes of histamine release during orthotopic homologous liver transplantation in the pig. Agents and Actions 3, 2–11 (1973)PubMedCrossRefGoogle Scholar
  28. 28.
    Lorenz, W., Seidel, W., Doenicke, A., Tauber, R., Reimann, H.-J., Uhlig, R., Mann, G., Dormann, P., Schmal, A., Häfner, G., Hamelmann, H.: Elevated plasma histamine concentrations in surgery: Causes and clinical significance. Klin. Wschr. 52, 419–425 (1974)PubMedCrossRefGoogle Scholar
  29. 29.
    Lorenz, W., Reimann, H.-J., Kusche, J., Barth, H., Schmal, A., Nusime, H., Schülle, G., Froelich, R., Schmidt, J., Raabe, R.: Effects of (+)-catechin on several enzymes of histamine metabolism and on stress ulcer formation in the female rat. Naunyn-Schmiedebergs Arch. Pharmacol. Suppl. 287, 62 (1976)Google Scholar
  30. 30.
    Lorenz, W.: Histamin H2-Rezeptorantagonisten. Dtsch. Ärztebl. 75, 173 (1978)Google Scholar
  31. 31.
    Lorenz, W., Doenicke, A.: Histamine release in clinical conditions. M. Sinai J. Med. 45, 357–386 (1978)Google Scholar
  32. 32.
    Ludwig, W.M., Lipkin, M.: Biochemical and cytological alterations in gastric mucosa of guinea pigs under restraint stress. Gastroenterology 56, 895 (1969)PubMedGoogle Scholar
  33. 33.
    Menguy, R., Masters, Y.F.: Effect of cortisone on mucoprotein secretion by gastric antrum of dogs: pathogenesis of steroid ulcer. Surgery 54, 19 (1963)PubMedGoogle Scholar
  34. 34.
    Reimann, H.-J., Lorenz, W., Fischer, M., Frölich, R., Meyer, H.-J., Schmal, A.: Histamine and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress ulcer formation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro. Agents and Actions 7, 69–73 (1977)PubMedCrossRefGoogle Scholar
  35. 35.
    Reimann, H.-J., Meyer, H.-J., Schmal, A., Fischer, M., Lorenz, W.: Adaptation und Kreuzadaptation an Kälte und Restraint zur Vermeidung von Streßulkusbildung bei der weiblichen Ratte. Z. phys. Med. 6, 22–23 (1977)Google Scholar
  36. 36.
    Rosenberg, A.: Production of gastric lesions in rats by combined cold and electrostress. Amer. J. dig. Dis. 12, 1140(1967)PubMedCrossRefGoogle Scholar
  37. 37.
    Schauer, A., Kunze, E., Feifel, G., Permanetter, W., Fraps, P.: Increased histidine and dopa decarboxylase activity in the rat stomach during restraint ulcer formation. Digestion 11, 12 (1974)PubMedCrossRefGoogle Scholar
  38. 38.
    Schumpelick, V., Rauchenberger, B.: Duodenogastraler Reflux und Streßulkus. Dtsch. med. Wschr. 101, 1647–1649 (1976)PubMedCrossRefGoogle Scholar
  39. 39.
    Seidel, W., Lorenz, W., Doenicke, A., Mann, G., Uhlig, R., Rohde, H.: Histaminfreisetzung beim Menschen und Streßulcuspathogenese. Z. Gastroent. 11, 297–300 (1973)Google Scholar
  40. 40.
    Selye, H.: The alarm reaction and the diseases of adaptation. Ann. intern. Med. 29, 403 (1948)PubMedGoogle Scholar
  41. 41.
    Thermann, M., Lorenz, W., Jostarndt, L.: Anaesthesist (in Vorbereitung)Google Scholar
  42. 42.
    Weber, E., Akovbiantz, A., Landolt, M., Koeltz, H.R., Nussbaumer, U., Peter, P., Blum, A.L.: Prospektive Studien über die postoperative Streßblutung. I. Epidemiologie. Dtsch. med. Wschr. 102, 152–155 (1977)PubMedCrossRefGoogle Scholar
  43. 43.
    Weiner, R., Altura, B.M.: Serotonin-bradykinin synergism in the mammalian capillary bed. Proc. Soc. exp. Biol. Med. (N.Y.) 124, 494 (1967)Google Scholar
  44. 44.
    Zweifach, B.W.: The behavior of the vascular barrier during tissue injury. Bibl. anat. (Basel) 4, 21(1964)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • W. Lorenz
  • H.-J. Reimann
  • M. Fischer

There are no affiliations available

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