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Microtubule Poisons

  • Chapter
Microtubules

Abstract

A small number of chemicals, principally colchicine, colchicine derivatives and the Vinca (Catharanthus) alkaloids, are capable of binding specifically to tubulin, preventing its assembly into MT. It is now indispensable to give further details about the action of these drugs, and of other chemicals which may have, under various conditions, similar effects. In the next chapters, colchicine and other poisons will often be mentioned, in relation to cell movements, secretion, and mitosis; their applications in various fields of medicine will be studied in Chapter 11. Here, the specific mechanisms of tubulin binding of these poisons, and the ways in which they alter MT functions will be analyzed. However, great care must be taken not to forget that some pharmacological effects of these drugs are unrelated to MT poisoning. As MT play such a diverse role in many cell functions, it is not always easy to find out which effect is mediated via changes in the MT. One approach to this, which has been followed by several authors, is to study the effects on a definite cell function of a series of chemically unrelated MT poisons: if they are similar, and can also be imitated by physical means, such as cold, high hydrostatic pressures, or by deuterium oxide, it can with some safety be concluded that the effects are mediated through MT poisoning and not by non-specific actions.

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    Prof. Dr. Pierre Dustin

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Dustin, P. (1978). Microtubule Poisons. In: Microtubules. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96436-7_7

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