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Secretion, Exo- and Endocytosis

  • Chapter
Microtubules

Abstract

The first mention of the word “microtubules” was made by Slautterback [103] in a description of secretory cells. However, it was only seven years later that Lacy et al. [53] suggested that MT play a role in the secretory activity of the B-cells of the Lan-gerhans islets. They showed that several agents known to modify MT (colchicine, VLB, VCR, and deuterium oxide) inhibited the release of insulin by these cells when stimulated by glucose. Similar findings concerning the thyroid gland were made in 1970 by two groups working independently [79, 122]. As a matter of fact, interest in colchicine and MT was revived in our laboratory by the research in these two fields carried on in Brussels [69, 78]. Since then, a large number of contributions have shown relations between MT and various modes of cell secretion, and have demonstrated that the integrity of MT is necessary for the cell activities related to the release of secretory granules.

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  1. Laboratoires d’Anatomie Pathologique et de Microscopie Electronique, Université Libre de Bruxelles, rue aux Laines 97, Bruxelles, B-1000, Belgium

    Prof. Dr. Pierre Dustin

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Dustin, P. (1978). Secretion, Exo- and Endocytosis. In: Microtubules. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96436-7_10

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  • DOI: https://doi.org/10.1007/978-3-642-96436-7_10

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