Immunologie: II Antikörper-vermittelte und Zellvermittelte Überempfindlichkeits- und Immunitätsreaktionen

  • Ernest Jawetz
  • Joseph L. Melnick
  • Edward A. Adelberg

Zusammenfassung

Bei der Mehrzahl der Antikörper-vermittelten Überempfindlichkeitsreaktionen besteht der wichtigste Mechanismus darin, daß sich Antikörper mit Antigenen zu Komplexen verbindet, die in der Lage sind, gewisse Zellen zur Freisetzung einer Vielzahl von Mediatoren zu veranlassen. Die wichtigsten Reaktionen sind die Anaphylaxie und die Serumkrankheit. Wechselwirkungen zwischen Antikörpern und Erythrocyten- oder Thrombocyten-Antigenen führen gewöhnlich nicht zur Freisetzung von Mediatoren.

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Literatur

  1. Austen, K. F.: Systemic anaphylaxis in the human being. New Engl. J. Med. 29, 661 (1974).Google Scholar
  2. Biggar, W. D., et al.: Immunologie reconsthution. Ann. Rev. Med. 24, 135 (1973).PubMedCrossRefGoogle Scholar
  3. Bloom, B. R., Glade, P. R.: In Vitro Methods in Cell-Mediated Immunity. New York: Academic Press 1971.Google Scholar
  4. Catalona, W. J., et al.:Dinitrochlorobenzene contact sensitization. New Engl. J. Med. 286, 399 (1972).PubMedCrossRefGoogle Scholar
  5. Collins, R. M.: Vaccines and cell-mediated immunity. Bact. Rev. 38, 371 (1974).PubMedGoogle Scholar
  6. Committee on Drugs of the American Academy of Pediatrics: Anaphylaxis. Pediatrics 51, 136 (1973).Google Scholar
  7. Dale, D. C., Petersdorf, R. G.: Corticosteroids and infectious diseases. Med. Clin. N. Amer. 57, 1277 (1973).PubMedGoogle Scholar
  8. Danilevicus, Z.: HL-A antigens: Markers of many diseases (Editorial). J. Amer. med. Ass. 231, 965 (1975).CrossRefGoogle Scholar
  9. David, J. R.: Lymphocyte mediators and cellular hypersenshivity. New Engl. J. Med. 288, 143 (1973).PubMedCrossRefGoogle Scholar
  10. Ellis, E. F.: Immunologic mechanisms in allergic disease. Pediat. Clin. N. Amer. 19, 373 (1972).PubMedGoogle Scholar
  11. Flax, M. H.: Drug-induced autoimmunity. New Engl. J.Med. 291, 414 (1974).PubMedCrossRefGoogle Scholar
  12. Flick, A. J.: Human reagins: The antibody of immediate type hypersenshivity. Bact. Rev. 36, 311 (1972).PubMedGoogle Scholar
  13. Freda, V. J., et al.: Prevention of Rh hemolytic diseases. New Engl. J. Med. 292, 1014 (1975).PubMedCrossRefGoogle Scholar
  14. Garraty, G., Petz, L. D.: Drug-induced hemolytic anemia. Amer. J. Med. 58, 398 (1975).CrossRefGoogle Scholar
  15. Hellström, K. E., Hellström, I.: Tumor immunity. Advanc. Cancer Res. 12, 167 (1969).CrossRefGoogle Scholar
  16. Kaliner, M., et al.: Immunologic release of chemical mediators from human nasal polyps. New Engl. J. Med. 289, 277 (1973).PubMedCrossRefGoogle Scholar
  17. Kaplan, S. R., Calabresi, P.: Immunosuppressive agents. New Engl. J. Med. 289, 952 (1973).PubMedCrossRefGoogle Scholar
  18. Leskowitz, S.: Tolerance. Ann. Rev. Microbiol. 21, 157 (1967).CrossRefGoogle Scholar
  19. Levin, A. S., et al.: Transfer factor therapy in immune deficiency states. Ann. Rev. Med. 24, 175 (1973).PubMedCrossRefGoogle Scholar
  20. McCluskey, R. T., Klasser, J.: Immunologically mediated renal disease. New Engl. J. Med. 288, 564 (1973).PubMedCrossRefGoogle Scholar
  21. McCombs, R. P.: Diseases due to immunologic reactions in the lungs. New Engl. J. Med. 286, 1186 (1972).PubMedCrossRefGoogle Scholar
  22. Najarian, J. S.: The clinical use of antilymphocyte globulin. New Engl. J. Med. 285, 158 (1971).PubMedCrossRefGoogle Scholar
  23. Palmer, D. L., Reed, W. P.: Delayed hypersensitivity skin teshng (2 parts) J. infect. Dis. 130, 132, 138 (1973)Google Scholar
  24. Parker, C. W.: Drug allergy. (2 parts) New Engl. J. Med. 292, 511, 732 (1975).PubMedCrossRefGoogle Scholar
  25. Paterson, R. Y.: Immune processes and infection factors in CNS disease. Ann. Rev. Med. 20, 75 (1969).PubMedCrossRefGoogle Scholar
  26. Stiller, C. R. et al.: Autoimmunity. Ann. intern. Med. 82, 405 (1975).PubMedGoogle Scholar
  27. Stossel, T. P.: Phagocytosis (3 parts). New Engl. J. Med. 290, 717, 774, 833 (1974).PubMedCrossRefGoogle Scholar
  28. Thomas, E. D., et al.: Bone marrow transplantation (2 parts). New Engl. J. Med. 292, 832, 895 (1975).PubMedCrossRefGoogle Scholar
  29. Tripodi, D., et al.: Drug-induced restoration of delayed type hypersensitivity. New Engl. J. Med. 289, 354 (1973).PubMedCrossRefGoogle Scholar
  30. Weiss, D. W., et al.: Current aspects of tumor immunology. Israel J. med. Sci. 9, 205 (1973).PubMedGoogle Scholar
  31. Wood, W. C., Morton, D. M.: Host immune response to cell-surface antigen in human sacromas. New Engl. J.Med. 284, 569 (1971).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1977

Authors and Affiliations

  • Ernest Jawetz
    • 1
  • Joseph L. Melnick
    • 2
  • Edward A. Adelberg
    • 3
  1. 1.Department of MicrobiologyUniversity of California School of MedicineSan FranciscoUSA
  2. 2.Baylor University College of MedicineHoustonUSA
  3. 3.Department of MicrobiologyYale University School of MedicineNew HavenUSA

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