Abstract
Radiation therapy depends for its success in curing patients upon certain relationships between the sensitivity of tumours and normal tissues to radiation. For successful treatment a tumour must be killed by a lower dose of radiation than would be needed to destroy the surrounding normal tissues. This is true whether we are dealing with children or adults. This relationship between tumour and normal tissues is known as the “Therapeutic Ratio” and should always be less than one if tumour lethal dose is put over the normal tissue tolerance dose [39]. Certain normal organs are more sensitive to radiation than others and care must be taken to recognize these differences so as not to exceed the doses leading to irreparable damage.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barendsen, G. W.: Responses of cultured cells, tumors and normal tissues to radiations of different linear energy transfer. In: Current Topics in Radiation Research (eds. M. Ebert, A. Howard) vol. 4, pp. 295. Amsterdam: North-Holland 1968.
Beaumont, H.M.: The radiosensitivity of germ cells at varions stages of ovarian development. Int. J. Radial. Biol. 4, 581 (1961).
Bewley, D. K.: Radiobiological research with fast neutrons and the implications for radiotherapy. Radiology 86, 251 (1966).
Bloedorn, F.G.: Radiation and surgery. In: Textbook of Radiotherapy (ed. G.J. Fletcher) pp. 99. London: Kimpton 1966.
Bolande, R.P., Brough, A.J., Izant, R.J.: Congenital mesoblastic n6phroma of infancy. A report of 8 cases and the relationship to Wilms’ tumor. Pediatrics 40, 272 (1967).
Broder, L.E., Carter, S.K.: Meningeal leukemia. New York-London: Plenum Press 1972.
D’Angio, G.J.: Pediatric cancer in perspective: Cure is not enough. Cancer 35, 866 (1975).
D’Angio, G.J., et al.: The National Wilms’ Tumor Study: a progress report. Proc. Natl. Cancer Conf. 7, 627 (1973).
D’Angio, G. J.: The use of combined actinomycin D and radiotherapy in children with Wilms’ tumor. In: Front. Radiation Ther. Onc. (ed. J.M. Vaeth) vol. 4, pp. 174. Basel-New York: S. Karger 1969.
D’Angio, G.J., Evans, A.E.: Wilms’ tumor can be cured. Annales de Radiologie 14,211 (1971).
D’Angio, G.J., Mitus, A., Evans, A.E.: The superior mediastinal syndrome in children with cancer. Amer. J. Roentgenol. 93, 537 (1965).
D’Angio, G.J., Farber, S., Maddock, C.L.: Potentiation of X-ray effects by actinomycin D. Radiology 73, 175 (1959).
D’Angio, G.J., Lawrence, J.H.: Medical research with high-energy heavy particles. Nucleonics 21, 56 (1963).
D’Angio, G.J., Nisce, L.Z.: Problems withirradiation of children and pregnant patients. J. Amer. Med. Ass. 233, 171 (1973).
Deeley, T. J.: Modern radiotherapy and oncology, malignant diseases in children. London: Butterworths 1974.
Ellis, F.: Dose, time and fractionation; a clinical hypothesis. Clin. Radiol. 20, 1 (1969).
Evans, A.E., D’Angio, G.J., Randolph, J.: A proposed staging for children with neuroblastoma, Children’s Cancer Study Group A. Cancer 27, 374 (1971).
Fowler, P. H., Perkins, D. H.: The possibility of therapeutic applications of beams of negative pi mesons. Nature 189, 524 (1961).
Glatstein, E., et al.: The value of laparotomy and splenectomy in the staging of Hodgkin’s disease. Cancer 24,709 (1969).
Grosfeld, J.L., Clatworthy, H. W., Newton, W.A.: Combined therapy in childhood rhabdomyosarcoma: an analysis of 42 cases. J. Pediat. Surg. 4, 637 (1969).
Hempelmann, L. H., et al.: Neoplasms in persons treated with X-rays in infancy for thymic enlargement. A report of the third follow-up survey. J. Nat. Cancer Inst. 38, 317 (1967).
Hilaris, B.: Techniques of interstitial and intracavitary radiation. Cancer 22, 745 (1968).
Hutchison, G.: Late neoplastic changes following medical irradiation. Radiology 105, 645 (1972).
Jaffe, N., et al.: Rhabdomyosarcoma in children—improved outlook with a multidisciplinary approach. Amer. J. Surg. 125,482 (1973).
Kaplan, H. S.: Hodgkin’s disease. Cambridge: Harvard University Press 1971.
Knudson, A.G.: Mutation in cancer: statistical study of retinoblastoma. Proc. Nat. Acad. Sci., Wash. 68, 820 (1971).
Knudson, A.G., Strong, L.C.: Mutation and cancer: a model for Wilms’ tumor of the kidney. J. Nat. Cancer Inst. 48, 313 (1972).
Koop, C.E., Johnson, D.G.: Neuroblastoma. An assessment of therapy in reference to staging. J. Pediat. Surg. 6, 595 (1971).
Kramer, S., Southard, M. E., Mansfield, C. M.: Radiation effects and tolerance of the central nervous system. In: Front. Radiation Ther. Onc. (ed. J. M. Vaeth) vol. 6, pp. 332. Baltimore-London-Tokyo: University Park Press 1972.
Laughlin, J. S.: Physical aspects of high energy electron therapy. Amer. J. Roentgenol. 99, 915 (1967).
Li, F.P., Fraumeni, J.P.: Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndrome. J. nat. Cancer Inst. 43,1365 (1969).
Marsden, H.B., Steward, J.K.: Recent Results in Cancer Research Vol. 13 Tumours in Children. Berlin, Heidelberg, New York: Springer 1968.
Meadows, A. T. et al.: Oncogenesis and other late effects of cancer treatment in children: report of a single hospital study. Radiology 114, 175 (1975).
Meadows, A. et al.: The influence of chemotherapy on second malignant neoplasms in irradiated children. Proceedings of the AACR 15, 175 (1974) (abstract).
Merrian, G.R., Szechter, A., Focht, E.F.: The effects of ionizing radiations on the eye. In: Front. Radiation Ther. Onc. (ed. J. M. Vaeth) vol. 6, pp. 346–385. Baltimore-London-Tokyo: University Park Press 1972.
Moroson, H. L., Quintiliani, M.: Radiation protection and sensitization. Proceedings, 2nd International Symposium on Radiosensitizing and Radioprotective Drugs. Rome: Taylor & Francis 1969.
Neuhauser, E.B.D., et al.: Irradiation effects of roentgen therapy on the growing spine. Radiology 59, 637 (1952).
O’Malley, B., D’Angio, G.J., Vawter, G.F.: Late effects of roentgen therapy given in infancy. Amer. J. Roentgenol. 89, 1067 (1963).
Paterson, R.: The treatment of malignant diseases by radium and X-rays. Baltimore: Williams & Wilkins 1963.
Pearson, D.: Malignant disease in children: Marie Curie Symposium Proceedings (In press).
Pearson, D.: Tumours of the central nervous system. In: Modern Radiotherapy and Oncology, Malignant Diseases in Children (ed. T.J. Deeley) pp. 98. London: Butterworths 1974.
Pearson, D., Duncan, W., Pointon, R.S.: Wilms’ tumours — a review of 96 consecutive cases. Brit. J. Radiol. 37,154 (1964).
Perez, C.: Basic concepts and clinical implications of radiation therapy. In: Clinical Pediatric Oncology (eds. W.W. Sutow, T.J. Vietti, D.J. Fernbach) pp. 28. St. Louis: C. V. Mosby Co. 1973.
Proceedings, 1st National Conference on Pediatric Oncology. Dallas, 1974 Cancer 35, 3 (1975).
Proimos, B. S.: Shaping the dose distribution through a tumor model. Radiology 92, 130 (1969).
Roberts, S., et al.: Technique and results of isolation of cancer cells from the circulating blood. Amer. Med. Assoc. Arch. Surg. 76, 333 (1958).
Rosen, G., et al.: Disease-free survival in children with Ewing’s sarcoma treated with radiation therapy and adjuvant four-drug sequential chemotherapy. Cancer 33, 384 (1974).
Roswit, B., Malsky, S.J., Reid, C.B.: Severe radiation injuries of the stomach, small intestine, colon, and rectum. Amer. J. Roentgenol. 114, 460 (1972).
Rubin, P., Casarett, G.W.: Clinical radiation pathology. Philadelphia-London-Toronto: W. B. Saunders 1968.
Sagerman, R. H., et al.: Radiation induced neoplasia following external beam therapy for children with retinoblastoma. Amer. J. Roentgenol. 105, 529 (1969).
Silver, H.K.: Wilms’ tumor (embryoma of the kidney). J. Pediat. 31, 643 (1947).
Sinclair, W. K.: Cyclic X-ray responses in mammalian cells in vitro. Radiat. Res. 33, 620 (1968).
Spar, I. L.: Genetic effects of radiation. Med. Clin. N. Amer. 53, 965 (1969).
Stallard, H. B.: Retinoblastoma. St. Bartholomew’s Hospital Journal 68, 1 (1964).
Sweetnam, R.D., Knowelden, J., Seddon, H.: Bone sarcoma: treatment by irradiation, amputation or a combination of the two. Brit. Med. J. 2, 363 (1971).
Tefft, M.: Radiation effect on growing bone and cartilage. In: Front. Radiation Ther. Onc. (ed. J.M. Vaeth) vol. 6, pp. 289. Basel-New York: S. Karger 1972.
Tefft, M., Vawter, G.F., Mitus, A.: Second primary neoplasms in children. Amer. J. Roentgenol. 103,800 (1968).
The National Wilms’ Tumor Study — Unpublished observations.
Thoday, J.M., Read, J.: Effects of oxygen on the frequency of chromosome aberrations produced by alpha rays. Nature 163, 133 (1949).
Upton, A. C.: Radiation carcinogenesis. In: Front. Radiation Ther. Onc. (ed. J.M. Vaeth) vol. 6, pp. 470. Baltimore-London-Tokyo: University Park Press 1972.
Vaeth, J.M.: Frontiers of radiation therapy and oncology. The interrelationship of chemotherapeutic agents and radiation therapy in the treatment of cancer. Vol. 4. Basel-New York: S. Karger 1969.
Van den Brenk, H.A.S., Madigan, J.P., Kerr, R.C.: Experience with megavoltage irradiation of advanced malignant disease using high pressure oxygen. In: Clinical Application of Hyperbaric Oxygen (ed. I. Boersma) p. 144. Amsterdam: Elsevier 1964.
Whitmore, W.F., Hilaris, B., Grabstald, D.: Retropubic implantation of Iodine 125 in the treatment of prostatic cancer. Trans. amer. Ass. gen.-urin. Surg. 64, 55 (1972).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1975 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Pearson, D., D’Angio, G.J. (1975). Radiation Therapy. In: Bloom, H.J.G., Lemerle, J., Neidhardt, M.K., Voûte, P.A. (eds) Cancer in Children. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96258-5_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-96258-5_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-07261-4
Online ISBN: 978-3-642-96258-5
eBook Packages: Springer Book Archive