Skip to main content
SpringerLink
Log in

Histiocytosis

  • Chapter
Cancer in Children

Abstract

Histiocytosis is a general term used to indicate pathological disorders of the reticuloendothelial system [1]. Cells of this system have recently been classified as the mononuclear phagocytic system (MPS) because of their common origin and function [19]. They behave as highly phagocytic cells and constitute an important defence system in the body against infections and foreign particulate matter as well as being an important cellular component of the afferent limb of the immune response. All of the cells originate from the promonocyte in the bone marrow. They then give rise to the peripheral monocyte which, in turn, gives rise to the tissue macrophage (histiocyte). The following tissue macrophages can be included in this system: connective tissue macrophages, Kupffer cells of the liver, alveolar and peritoneal macrophages, free and fixed macrophages of the spleen and bone marrow, sinusoidal lining cells of the spleen and bone marrow as well as osteoclasts and nervous system microglial cells. This new classification excludes the endothelial cells, fibroblasts, lymphocytes and muscle cells which in the past were included in the reticulo-endothelial system.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aschoff, L: Das reticulo-endotheliale System, Ergeb. Inn. Med. und Kinderheilk. 26,1 (1924).

    Google Scholar 

  2. Balfour, H.: Juvenile xanthogranuloma associated with cytomegalovirus infection, Amer. J. Med. 50, 380 (1971).

    Article  PubMed  Google Scholar 

  3. Claman, H.N., Suvatte, V., Githens, J., Hathaway, W.: Histiocytic reaction in dysgammaglobulinemia and congenital rubella. Pediatrics 46, 89 (1970).

    PubMed  CAS  Google Scholar 

  4. Clawson, C.C., Rodey, G.E., Good, R.A.: Ultrastructure of familial lipochrome histiocytosis. Laboratory Investigation 22, 294 (1970).

    PubMed  CAS  Google Scholar 

  5. Crocker, A.: The Histiocytosis Syndromes. In: Current Pediatric Therapy (ed. S.S. Gellis, B.M. Kagan) p. 372. Philadelphia-London-Toronto: W.B. Saunders Company 1971.

    Google Scholar 

  6. Farqubar, J. W., McGregor, A., Richmond, J.: Familial haemophagocytic reticulosis. Brit. Med. J. 1958 II, 1561.

    Article  Google Scholar 

  7. Finberg, F.B., Ester, R.J.: Roentgen examination of the gastrointestinal tract as an aid in the diagnosis in acute and subacute reticuloendotheliosis. Radiology 71, 525 (1958).

    Google Scholar 

  8. Finberg, S.B., Langer, L.O.: Roentgen findings of increased intracranial pressure and communicating hydrocephalus as insidious manifestations of chronic histiocytosis X. Radiology 95, 41 (1965).

    Google Scholar 

  9. Freud, P.: Treatment of reticuloendotheliosis. J. Amer. Med. Ass. 175, 82 (1961).

    Article  CAS  Google Scholar 

  10. Friedman, R., Steigbigel, N.: Histiocytic medullary reticulosis. Amer. J. Med. 38,130 (1965).

    Article  PubMed  CAS  Google Scholar 

  11. Gajl-Peczalska, K.J., Lim, S.D., Jacobson, R.R., Good, R.A.: B lymphocytes in lepromatous leprosy. New Engl. J. Med. 288,1033 (1973).

    Article  PubMed  CAS  Google Scholar 

  12. Githens, J.H., Muschenheim, F., Fulginiti, V.A., Robinson, K., Kay, H.E.: Thymic alymphoplasia with XX/XY lymphoid chimerism secondary to probable maternal-fetal transfusion. J. Ped. 75, 87 (1969).

    Article  CAS  Google Scholar 

  13. Hathaway, W.E., Brangle, R.W., Nelson, T.L., Roeckel, I. E.: Aplastic anemia and alymphocytosis in an infant with hypogammaglobulinemia: Graft-versus-host reaction? J. Ped. 68, 713 (1966).

    Article  CAS  Google Scholar 

  14. Helbock, H., Krivit, W., Nesbit, M.: Patterns of antidiuretic function in diabetes insipidus caused by histiocytosis X. J. Clin. Lab. Med. 78, 194 (1971).

    CAS  Google Scholar 

  15. Holm, J.E., Teilum, G., Christensen, E.: Eosinophilic granuloma of bone: SchUller-Christian disease. Acta Med. Scand. 118,292 (1944).

    Article  Google Scholar 

  16. Holman, G.: Familial reticulosis with eosinophilia. New Engl. J. Med. 273, 427 (1965).

    Article  Google Scholar 

  17. Kempe, C.H.: Aplastic anemia, histiocytosis and erythrodermia in immunologically deficient children — probably human runt disease. New Engl. J. Med. 273, 953 (1965).

    Article  PubMed  Google Scholar 

  18. Lahey, M.E.: Comparison of three regimens in histiocytosis X in children. Proc. 10th Int. Canc. Congr. 764 (1970).

    Google Scholar 

  19. Langevoort, H.L., Cohn, Z.A., Hirsh, J.G., Humphrey, J.H., Spector, W.J., van Furth, R.: The nomenclature of mononuclear phagocytic cells: Proposal for a new classification in mononuclear phagocytes (ed. R. van Furth), p. 1. Oxford and Edinburgh, England: Blackwell Scientific Publications Ltd. 1970

    Google Scholar 

  20. Lieberman, P.H., Jones, C.R., Dargeon, H.W., Berg, C. S.: A reappraisal of eosinophilic granuloma of bone, Hand-Schüller-Christian syndrome and Letterer-Siwe syndrome. Medicine 48, 375 (1969).

    Article  PubMed  CAS  Google Scholar 

  21. Lichtenstein, L.: Histiocytosis X. Integration of eosinophilic granuloma of bone, “Letterer-Siwe disease” and “Schüller-Christian disease” as related manifestations of a single nosologic entity. Arch. Path. 56, 84 (1953).

    CAS  Google Scholar 

  22. Nesbit, M.E., Kieffer, S., D’Angio, G.J.: Reconstitution of vertebral height in histiocytosis X: a long term follow-up. J. Bone Joint Surg. 51A, 1360 (1969).

    Google Scholar 

  23. Newton, W.A., Hamoudi, A.B.: Histiocytosis: A histologic classification with clinical correlation (ed. H.S. Rosenberg and R.P. Bolande), p. 251. Chicago: Year Book Medical Publishers, Inc. 1973

    Google Scholar 

  24. Rosai, J., Dorfman, R. F.: Sinus histiocytosis with massive lymphadenopathy. Arch. Path. 87, 63 (1969).

    PubMed  CAS  Google Scholar 

  25. Rywlin, A.M., Hoffman, E.P., Ortega, R.F.: Eosinophilic fibrohistiocytic lesion of bone marrow: A distinctive new morphological fmding, probably related to drug hypersensitivity. Blood 40,464 (1972).

    PubMed  CAS  Google Scholar 

  26. Smith, D.G., Nesbit, M.E., D’Angio, G.J., Levitt, S. H.: Histiocytosis X. Role of radiation therapy in management with special reference to dose levels employed. Radiology 106, 419 (1973).

    PubMed  CAS  Google Scholar 

  27. Starling, K.A.: Therapy of histiocytosis X with vincristine, vinblastine and cyclophosphamide. Amer. J. Dis. Child. 123, 105 (1972).

    PubMed  CAS  Google Scholar 

  28. Starling, K.A., Fernbach, D.J.: Histiocytosis. In: Clinical Pediatric Oncology (ed. W. W. Sutow, T.J. Vietti, D.J. Fernbach) p. 337. Saint Louis: The C. V. Mosby Company 1973.

    Google Scholar 

Recommended Reading

  1. Dargeon, H.: Reticuloendotheliosis in childhood. Springfield: C.C. Thomas 1966.

    Google Scholar 

  2. Lahey, M.E.: Prognosis in reticuloendotheliosis in children. J. Ped. 60, 664 (1972).

    Article  Google Scholar 

  3. Lieberman, P. H., Jones, C. R., Dargeon, H. W., Berg, C. S.: A reappraisal of eosinophilic granuloma of bone, Hand-Schüller-Christian Syndrome and Letterer-Siwe Syndrome. Medicine 48,375 (1969).

    Article  PubMed  CAS  Google Scholar 

  4. Nesbit, M. E., Sharp, H. L., Krivit, W.: Histiocytosis X. In: Practice of Pediatrics (ed. J. Brennemann, V.C. Kelly) Vol. III, p. 1. Hagerstown, Maryland: Harper & Row 1966.

    Google Scholar 

  5. Vogel, J.M., Vogel, P.: Idiopathic histiocytosis: A discussion of eosinophilic granuloma, Hand-Schüller-Christian Syndrome and Letterer-Siwe Syndrome. Sem. Hematol. 9, 349 (1972).

    CAS  Google Scholar 

Download references

Authors
  1. M. E. Nesbit Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Krivit
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiotherapy, Royal Marsden Hospital and Institute of Cancer Research, London and Surrey, UK

    H. Julian G. Bloom (Vice-Chairman, Consultant Radiotherapist, Hon. Consultant Radiotherapist (Neurosurgery) (Vice-Chairman, Consultant Radiotherapist, Hon. Consultant Radiotherapist (Neurosurgery)

  2. Queen Mary’s Hospital for Children, Carshalton, Surrey, UK

    H. Julian G. Bloom (Vice-Chairman, Consultant Radiotherapist, Hon. Consultant Radiotherapist (Neurosurgery) (Vice-Chairman, Consultant Radiotherapist, Hon. Consultant Radiotherapist (Neurosurgery)

  3. St.Peter’s Group of Urological Hospitals, London, UK

    H. Julian G. Bloom (Vice-Chairman, Consultant Radiotherapist, Hon. Consultant Radiotherapist (Neurosurgery) (Vice-Chairman, Consultant Radiotherapist, Hon. Consultant Radiotherapist (Neurosurgery)

  4. St. George’s Hospital, London, England

    H. Julian G. Bloom (Vice-Chairman, Consultant Radiotherapist, Hon. Consultant Radiotherapist (Neurosurgery) (Vice-Chairman, Consultant Radiotherapist, Hon. Consultant Radiotherapist (Neurosurgery)

  5. Department of Paediatrics, Institut Gustave-Roussy, Villejuif, France

    Jean Lemerle

  6. First Paediatric Hospital, Augsburg, Federal Republic of Germany

    Malte K. Neidhardt (Chief) (Chief)

  7. Department of Paediatric Oncology, Emmakinderziekenhuis and Netherlands Cancer Institute, Amsterdam, The Netherlands

    Paul A. Voûte

Rights and permissions

Reprints and permissions

Copyright information

© 1975 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Nesbit, M.E., Krivit, W. (1975). Histiocytosis. In: Bloom, H.J.G., Lemerle, J., Neidhardt, M.K., Voûte, P.A. (eds) Cancer in Children. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96258-5_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-96258-5_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-07261-4

  • Online ISBN: 978-3-642-96258-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation