Acne pp 58-107 | Cite as

The Dynamics of Primary Comedo Formation

  • Gerd Plewig
  • Albert M. Kligman


Two tactics have been of inestimable value for observing anatomical changes of the evolving disease: These are (1) serial sectioning and (2) biopsying apparently uninvolved areas of acne-bearing skin. Without the latter the earliest changes would not have been seen. Without serial sections many changes would have remained concealed; one section of the same specimen may look normal while elsewhere there may be startling alterations. Asymmetry is quite characteristic of acne lesions.


Stratum Corneum Granular Layer Sebaceous Follicle Horny Layer Acne Lesion 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1975

Authors and Affiliations

  • Gerd Plewig
    • 1
  • Albert M. Kligman
    • 2
  1. 1.Department of DermatologyUniversity of MunichMunich 2Germany
  2. 2.School of Medicine, Duhring LaboratoriesUniversity of PennsylvaniaPhiladelphiaUSA

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