Abstract
The hypothalamus has a diameter of only 2.5 cm and makes up 1/300th of the weight of the brain. Nevertheless, this tiny organ coordinates and regulates most of the vital processes of life. Modulations are effected through neural and neuro-endocrine routes. The schema of Harris (Fig. 1) shows how the humoral substances secreted by neurons can affect the endorgans, with or without intervention of the endocrine system. The physiologic and clinical aspects of the hypothalamus will only be discussed in relation to their influence on the endocrine system, as befits a textbook of endocrinology.
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References
Review Articles
Bajusz, E.: Modern trends in neuroendocrinology with special reference to clinical problems. In: Bajusz, Clinical neuroendocrinology. Basel-New York: Karger 1967.
— Jassmin, G.: Major problems in neuroendocrinology. Basel-New York: Karger 1964.
Bargmann, W., Scharrer, B. (Editors): Aspects of Neuroendocrinology. Berlin-Heidelberg-New York: Springer 1970.
Bauer, H.G.: Introduction. In: Bajusz, Clinical neuroendocrinology. Basel-New York: Karger 1967.
Editorial: Hypothalamic releasing hormones. Brit. med. J. 1972 I, 65.
Ganong, W. F., Martini, L.: Frontiers in neuroendocrinology. New York: Oxford University Press 1969.
Guillemin, R.: Hypothalamic control of the secretion of adenohypophysial hormones. Adv. metabol. Disorders 5, 1 (1971).
Hess, W.R.: Das Zwischenhirn. Basel: Schwabe 1949, 1954.
Levine, R. : Endocrines and the central nervous system. Baltimore: Williams & Wilkins 1966.
Locke, W., Schally, A. V. (eds.): The hypothalamus and pituitary in health and disease. Springfield, Ill.: Thomas 1972.
Martini, L., Ganong, W.F.: Neuroendocrinology. New York and London: Academic Press 1966.
— Meites, J. (eds.): Neurochemical aspects of hypothalamic function. New York: Academic Press 1970.
— Motta, M., Fraschini, F. (eds.): The hypothalamus. New York and London: Academic Press 1970.
Nalbandov, A.V. (Editor): Advances in neuroendocrinology. Urbana: Univ. of Illinois Press 1963.
Reichlin, S.: Neuroendocrinology. New Engl. J. Med. 260, 1182, 1246, 1296 (1963).
— Function of the hypothalamus. Amer. J. Med. 43, 477 (1967).
Scharrer, E., Scharrer, B.: Neuroendocrinology. Columbia: Univ. Press 1963.
Stutinsky, F. : Neurosecretion. Berlin-Heidelberg-New York: Springer 1967.
Szentagothai, J., Flerko, B., Mess, B., Halasz, B.: Hypothalamic control of the anterior pituitary. An experimental-morphological study. 3rd (second english) edit. Budapest: Akadémiai Kiado 1968.
Embryology and Anatomy
Bargmann, W.: Das Zwischenhirn-Hypophysensystem. Berlin-Göttingen-Heidelberg: Springer 1954.
— Neurohypophysis. Structure and function. In: Handbuch der experimentellen Pharmakologie, vol. XXIII, ed. by B. Berde. Berlin-Heidelberg-New York: Springer 1968.
Diepen, R.: Der Hypothalamus. In: Handbuch der mikroskopischen Anatomie des Menschen. Hrsg. W. Bargmann, Bd.IV/7. Berlin-Göttingen-Heidelberg: Springer 1962.
Engelhardt, Fr.: Morphologische Grundlagen der Beziehungen zwischen Hypophyse und Hypothalamus. In: Handbuch der Neurochirurgie, Bd. I/2. Hrsg. H. Olivecrona und W. Tönnis. Berlin-Göttingen-Heidelberg: Springer 1968.
Scharrer, E., Scharrer, B.: Neurosekretion. In: W. Von Möllendorf U. W. Bargmann’s Handbuch der mikroskopischen Anatomie des Menschen, Bd. VI/5. Berlin-Göttingen-Heidelberg: Springer 1954.
Starck, D.: Embryologie. Stuttgart: Thieme 1965.
Biochemistry and Physiology
Akert, K.: Physiologie und Pathophysiologic des Hypothalamus. In: Schaltenbrand Und Bailey, Einführung in die stereotaktischen Operationen. I. Stuttgart: Thieme 1959.
Baba, Y., Matsuo, H., Schally, V.: Structure of the porcine LH- and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses. Biochem. biophys. Res. Commun. 44, 459 (1971).
Blanco, S., Schalch, D.S., Reichlin, S.: Control of Growth Hormonal-secretion by glucoreceptors in the hypothalamic-pituitary unit. Fed. Proc. 25, 191 (1966).
Bøler, J., Enzmann, F., Folkers, K., Bowers, C. Y., Schally, A.V.: The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyro- glutamyl-histidyl-proline-amide. Biochem. biophys. Res. Commun. 37, 705 (1969).
Burgus, R., Donn, Th.F., Desiderio, D. M., Ward, D.N., Vale, W., Guillemin, R., Felix, P.M., Gillessen, D., Studer, R. O.: Biological activity of synthetic polypeptide derivatives related to the structure of hypothalamic Trf. Endocrinology 86, 573 (1970).
De Groot, J.: Limbic and other neural pathways that regulate endocrine function. In: Neuroendocrinology, ed. by Martini and Ganong. New York and London: Academic Press 1966.
Enoch, D.M., Kerr, F.W.L.: Hypothalamic vasopressor and vesicopressor pathways. Arch. Neurol. (Chic.) 16, 290 (1967).
Frohman, L. A.: Clinical neuropharmacology of hypothalamic releasing factors. New Engl. J. Med. 286, 1391 (1972).
Geschwind, I.I.: Mechanism of action of releasing factors. In: Frontiers in neuroendocrinology, ed. Ganong, W.F., Martini, L. New York: Oxford University Press 1969.
Gillessen, D., Felix, A.M., Lergier, W., Studer, R.O.: Synthese des Thyrotropin releasing-Hormons (TRH) (Schaf) und verwandter Peptide. Helv. chim. Acta 53, 63 (1970).
Hall, R., Amos, J., Garry, R., Buxton, R.L.: Thyroidstimulating hormone response to synthetic thyrotrophin releasing hormone in men. Brit. med. J. 1970/II, 274.
Hammerschlag, R., Leeman, S.E.: Induction of salivation by a bovine hypothalamic factor. Fed. Proc. 25, 192 (1966).
Harris, G.W.: Humors and hormones. J. Endocr. 53, II (1972).
Hess, W.R.: Die funktionelle Organisation des vegetativen Nervensystems. Basel: Benno Schwabe 1948.
Mccann, S.M., Porter, J.C.: Hypothalamic pituitary stimulating and inhibiting hormones. Physiol. Rev. 49, 240 (1969).
Meites, J.: Hypophysiotropic hormones of the hypothalamus: Assay and chemistry. Baltimore: Williams & Wilkins Co. 1970.
Nair, R. M. G., Barrett, J.F., Bowers, C. Y., Schally, A.V.: Structure of porcine thyrotropin releasing hormone. Biochemistry 9, 1103 (1970).
— Kastin, A.J., Schally, A. V.: Isolation and structure of hypothalamic MSH release-inhibiting hormone. Biochem. biophys. Res. Commun. 43, 1376 (1971).
Nauta, W. J. H.: Central nervous organization and the endocrine motor system in Nalbandov, A. V.: Advances in Neuroendocrinology. Urbana: Univ. Illinois Press 1963.
Raisman, G.: Neural connections of the hypothalamus. Brit. med. Bull. 22, 197 (1966).
Reichlin, S.: Functions of the median-eminence gland. New Engl. J. Med. 275, 600 (1966).
Rothballer, A. B.: Some endocrine manifestations of central nervous system disease. An approach to clinical neuroendocrinology. Bull. N.Y. Acad. Med. 4, 257 (1966).
Ruf, K., Steiner, F. A.: Steroid-sensitive single neurons in rat hypothalamus and midbrain: Identification by microelectrophoresis. Science 156, 667 (1967).
Schally, A.V., Arimura, A., Bowers, C.Y., Kastin, A. J., Sawano, S., Redding, T.W.: Hypothalamic neurohormones regulating anterior pituitary function. Recent Progr. Hormone Res. 24, 497 (1968).
— Baba, V., Bennett, C.D.: The amino acid sequence of a peptide with growth hormone-releasing activity isolated from porcine hypothalamus. J. biol. Chem. 246, 6647 (1971).
Schaltenbrand, G., Bailey, P.: Einführung in die stereotaktischen Operationen mit einem Atlas des menschüchen Gehirns. Stuttgart: Thieme 1959.
Scharrer, E.: Principles of neuroendocrine integration. In: Levine, R., Endocrines and the central nervous system. Baltimore: Wilhams & Wilkins 1966.
— Scharrer, B.: Hormones produced by neurosecretory cells. Recent Progr. Hormone Res. 10, 183 (1954).
Spatz, H.: Das Hypothalamus-Hypophysen-System in Hinsicht auf die zentrale Steuerung der Sexualfunktionen. Beriin-Göttingen-Heidelberg: Springer 1955.
Studer, R., Werner, I.: Thyrotropin-releasing factor (TRF). Schweiz. med. Wschr. 100, 1086 (1970).
Szentagothai, J., Flesko, B., Mess, B., Halasz, B.: Hypothalamic control of the anterior pituitary, 3rd ed. Budapest: Publ. House Hung. Acad. Sci. 1968.
Vale, W., Burgus, R., Dunn, TH.F., Guillemin, R.: Release of TSH by oral administration of synthetic peptide derivatives with TRF activity. J. din. Endocr. 30, 148 (1970).
Veber, D.F., Bennett, C. D., Milkowski, J. D., Gal, G., Denkewalter, R.G., Hirschmann, R.: Synthesis of a proposed growth hormone releasing factor. Biochem. biophys. Res. Commun. 45, 235 (1971).
Yates, F.E., Russell, S.M., Maran, J.W.: Brain-adenohypophysial communication in mammals. Ann. Rev. Physiol. 33, 393 (1971).
Pathology and Clinics
Albright, F., Reifenstein, E. C.: The parathyroid glands and metabolic bone disease. Baltimore: Williams & Wilkins Company 1948.
Bauer, H.C.: Endocrine and other clinical manifestations of hypothalamic disease. A survey of 60 cases with autopsies. J. din. Endocr. 14, 13 (1954).
— Endocrine and metabolic conditions related to pathology in the hypothalamus: a review. J. nerv. ment. Dis. 128, 323 (1959).
Betghe, H., Irmscher, K., Zimmermann, H.: Das Verhalten der Corticosteroide im Plasma während der Insulinhypoglykämie und unter Lysin-Vasopressin als Funktionsprüfung des Hypothalamus-Hypophysen-Nebennierenrinden-Systems. Acta endocr. (Kbh.) 55, 622 (1967).
Bierich, J. R., Braun, W.: Endokrine Störungen bei Zwischenhirnerkrankungen. Verh. dtsch. Ges. inn. Med. 71, 282 (1965).
Courvoisier, B., Fasel, J., Vernet, A., Berthoud, E.: Tuberculose atypique avec syndrome hypothalamo-hypophysaire progressif aboutissant à un panhypopituitarisme. Schweiz. med. Wschr. 90, 870 (1960).
Eik-Nes, K., Clark, L.D.: Diurnal variation of plasma 17-hydroxycorticosteroids in subjects suffering from severe brain damage. J. din. Endocr. 18, 764 (1958).
Hall, R., Warrick, CH.: Hypersecretion of hypothalamic releasing hormones: A possible explanation of the endocrine manifestations of polyostotic fibrous dysplasia (Albright’s syndrome). Lancet 1972 I, 1313.
Hedinger, Chr., Hürzeler, D.: Hypopituitarismus bei Dystopie des Hypophysenhinterlappens. Acta endocr. (Kbh.) 14, 170 (1953).
Hokfelt, B., Luft, R.: The effect of suprasellar tumours on the regulation of adrenocortical function. Acta endocr. (Kbh.) 32, 177 (1959).
Kahana, L., Kahana, S., Mcpherson, H.T.: Endocrine manifestations of intracranial extrasellar lesions. In: Bajusz, Clinical neuroendocrinology. Basel-New York: Karger 1967.
— Lebovitz, H., Lusk, W., Mcpherson, H.T., Davidson, E.T., Oppenheimer, J. H., Engel, F.L., Woodhall, B., Odom, G.: Endocrine manifestations of intracranial extrasellar lesions. J. din. Endocr. 22, 304 (1962).
Krayenbühl, H., Zollinger, H. U.: Malignes metastasierendes Pinealocytom mit dem khnischen Bild der Dystrophia adiposo-genitalis. Schweiz. Arch. Neurol. 51, 77(1943).
Krieger, D.T., Krieger, H. P.: Effects of organic brain lesions on adrenal cortical activity. In: Levine, R., Endocrines and the central nervous system. Baltimore: Williams & Wilkins 1966.
Landon, J., Greenwood, F. C., Stamp, T. C. G., Wynn, V.: The plasma sugar, free fatty acid, Cortisol and growth hormone response to insulin and the comparison of this procedure with other tests of pituitary and adrenal function. II. In Patients with hypothalamic or pituitary dysfunction or anorexia nervosa. J. din. Invest. 45, 437 (1966).
Lange-Cosack, H.: Zur Frage der hypothalamischen Pubertas praecox. In: Zentrale Steuerung der Sexualfunktionen. Berlin-Heidelberg-New York: Springer 1966.
Linquette, M., Laine, E., Fossati, P., Lefebvre, J.: Pinéalome ectopique avec insuffisance hypophysaire antérieure, adipsie et hypernatrémie neurogene. Ann. Endocr. (Paris) 28, 39 (1967).
Lipsett, M. B., Dreifuss, F. E., Thomas, L. B.: Hypothalamic syndrome following varicella. Amer. J. Med. 32, 471 (1962).
Martin, L.G., Martul, P., Connor, T. B., Wiswell, J.G.: Hypothalamic origin of idopathic hypopituitarism. Metabolism 21, 143 (1972).
Morgan, T., Coupland, W. G., Vanderfield, G. K., Church, D.: Hypothalamic-pituitary sarcoidosis. Aust. Ann. Med. 14, 250 (1965).
Nowakowski, H.: Ãœber die endokrine Symptomatik bei Erkrankungen des Hypothalamus. Verh. dtsch. Ges. inn. Med. 61, 49 (1955).
Oppenheimer, J. H., Fisher, L. V., Jailer, J. W.: Disturbance of the pituitary-adrenal interrelationship in diseases of the central nervous system. J. din. Endocr. 21, 1023 (1961).
Orthner, H.: Pathologische Anatomie und Physiologie der hypophysär-hypothalamischen Krankheiten. In: Handbuch der speziellen pathologischen Anatomie und Histologie, O. Lubarsch, F. Henke, R. Rössle, Bd. XIII, Nervensystem, Teil 5, S. 543–939. Berlin-Göttingen-Heidelberg: Springer 1955.
Rothballer, A. B.: Some endocrine manifestations of central nervous system disease. Bull. N.Y. Acad. Med. 42, 257 (1966).
Wolff, S. M., Adler, R. C., Buskirk, E. R., Thompson, R. H.: A syndrome of periodic hypothalamic discharge. Amer. J. Med. 36, 956 (1964).
Wyk, J. J. Van, Dugger, G. S., Newsome, J. F., Thomas, P. Z.: The effect of pituitary stalk section on the adrenal function of women with cancer of the breast. J. din. Endocr. 20, 157 (1960).
Added in Proofs
Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J., Guillemin, R.: Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 179, 77 (1973).
Gual, C., Rosemberg, E. (eds.): Hypothalamic hypophysiotropic hormones; physiological and clinical studies. Excerpta med. (Amst.) (1973).
Schally, A. V., Arimura, A., Kastin, A. J.: Hypothalamic regulatory hormones. Science 179, 341 (1973).
Wilber, J.F.: Thyrotropin releasing hormone: secretion and actions. Ann. Rev. Med. 24, 353 (1973).
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Labhart, A. (1974). The Hypothalamus. In: Clinical Endocrinology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96158-8_2
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DOI: https://doi.org/10.1007/978-3-642-96158-8_2
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