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The Hypothalamus

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Clinical Endocrinology
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Abstract

The hypothalamus has a diameter of only 2.5 cm and makes up 1/300th of the weight of the brain. Nevertheless, this tiny organ coordinates and regulates most of the vital processes of life. Modulations are effected through neural and neuro-endocrine routes. The schema of Harris (Fig. 1) shows how the humoral substances secreted by neurons can affect the endorgans, with or without intervention of the endocrine system. The physiologic and clinical aspects of the hypothalamus will only be discussed in relation to their influence on the endocrine system, as befits a textbook of endocrinology.

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References

Review Articles

  • Bajusz, E.: Modern trends in neuroendocrinology with special reference to clinical problems. In: Bajusz, Clinical neuroendocrinology. Basel-New York: Karger 1967.

    Google Scholar 

  • — Jassmin, G.: Major problems in neuroendocrinology. Basel-New York: Karger 1964.

    Google Scholar 

  • Bargmann, W., Scharrer, B. (Editors): Aspects of Neuroendocrinology. Berlin-Heidelberg-New York: Springer 1970.

    Google Scholar 

  • Bauer, H.G.: Introduction. In: Bajusz, Clinical neuroendocrinology. Basel-New York: Karger 1967.

    Google Scholar 

  • Editorial: Hypothalamic releasing hormones. Brit. med. J. 1972 I, 65.

    Google Scholar 

  • Ganong, W. F., Martini, L.: Frontiers in neuroendocrinology. New York: Oxford University Press 1969.

    Google Scholar 

  • Guillemin, R.: Hypothalamic control of the secretion of adenohypophysial hormones. Adv. metabol. Disorders 5, 1 (1971).

    CAS  Google Scholar 

  • Hess, W.R.: Das Zwischenhirn. Basel: Schwabe 1949, 1954.

    Google Scholar 

  • Levine, R. : Endocrines and the central nervous system. Baltimore: Williams & Wilkins 1966.

    Google Scholar 

  • Locke, W., Schally, A. V. (eds.): The hypothalamus and pituitary in health and disease. Springfield, Ill.: Thomas 1972.

    Google Scholar 

  • Martini, L., Ganong, W.F.: Neuroendocrinology. New York and London: Academic Press 1966.

    Google Scholar 

  • — Meites, J. (eds.): Neurochemical aspects of hypothalamic function. New York: Academic Press 1970.

    Google Scholar 

  • — Motta, M., Fraschini, F. (eds.): The hypothalamus. New York and London: Academic Press 1970.

    Google Scholar 

  • Nalbandov, A.V. (Editor): Advances in neuroendocrinology. Urbana: Univ. of Illinois Press 1963.

    Google Scholar 

  • Reichlin, S.: Neuroendocrinology. New Engl. J. Med. 260, 1182, 1246, 1296 (1963).

    Article  Google Scholar 

  • — Function of the hypothalamus. Amer. J. Med. 43, 477 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Scharrer, E., Scharrer, B.: Neuroendocrinology. Columbia: Univ. Press 1963.

    Google Scholar 

  • Stutinsky, F. : Neurosecretion. Berlin-Heidelberg-New York: Springer 1967.

    Google Scholar 

  • Szentagothai, J., Flerko, B., Mess, B., Halasz, B.: Hypothalamic control of the anterior pituitary. An experimental-morphological study. 3rd (second english) edit. Budapest: Akadémiai Kiado 1968.

    Google Scholar 

Embryology and Anatomy

  • Bargmann, W.: Das Zwischenhirn-Hypophysensystem. Berlin-Göttingen-Heidelberg: Springer 1954.

    Book  Google Scholar 

  • — Neurohypophysis. Structure and function. In: Handbuch der experimentellen Pharmakologie, vol. XXIII, ed. by B. Berde. Berlin-Heidelberg-New York: Springer 1968.

    Google Scholar 

  • Diepen, R.: Der Hypothalamus. In: Handbuch der mikroskopischen Anatomie des Menschen. Hrsg. W. Bargmann, Bd.IV/7. Berlin-Göttingen-Heidelberg: Springer 1962.

    Google Scholar 

  • Engelhardt, Fr.: Morphologische Grundlagen der Beziehungen zwischen Hypophyse und Hypothalamus. In: Handbuch der Neurochirurgie, Bd. I/2. Hrsg. H. Olivecrona und W. Tönnis. Berlin-Göttingen-Heidelberg: Springer 1968.

    Google Scholar 

  • Scharrer, E., Scharrer, B.: Neurosekretion. In: W. Von Möllendorf U. W. Bargmann’s Handbuch der mikroskopischen Anatomie des Menschen, Bd. VI/5. Berlin-Göttingen-Heidelberg: Springer 1954.

    Google Scholar 

  • Starck, D.: Embryologie. Stuttgart: Thieme 1965.

    Google Scholar 

Biochemistry and Physiology

  • Akert, K.: Physiologie und Pathophysiologic des Hypothalamus. In: Schaltenbrand Und Bailey, Einführung in die stereotaktischen Operationen. I. Stuttgart: Thieme 1959.

    Google Scholar 

  • Baba, Y., Matsuo, H., Schally, V.: Structure of the porcine LH- and FSH-releasing hormone. II. Confirmation of the proposed structure by conventional sequential analyses. Biochem. biophys. Res. Commun. 44, 459 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Blanco, S., Schalch, D.S., Reichlin, S.: Control of Growth Hormonal-secretion by glucoreceptors in the hypothalamic-pituitary unit. Fed. Proc. 25, 191 (1966).

    Google Scholar 

  • Bøler, J., Enzmann, F., Folkers, K., Bowers, C. Y., Schally, A.V.: The identity of chemical and hormonal properties of the thyrotropin releasing hormone and pyro- glutamyl-histidyl-proline-amide. Biochem. biophys. Res. Commun. 37, 705 (1969).

    Article  PubMed  Google Scholar 

  • Burgus, R., Donn, Th.F., Desiderio, D. M., Ward, D.N., Vale, W., Guillemin, R., Felix, P.M., Gillessen, D., Studer, R. O.: Biological activity of synthetic polypeptide derivatives related to the structure of hypothalamic Trf. Endocrinology 86, 573 (1970).

    Article  PubMed  CAS  Google Scholar 

  • De Groot, J.: Limbic and other neural pathways that regulate endocrine function. In: Neuroendocrinology, ed. by Martini and Ganong. New York and London: Academic Press 1966.

    Google Scholar 

  • Enoch, D.M., Kerr, F.W.L.: Hypothalamic vasopressor and vesicopressor pathways. Arch. Neurol. (Chic.) 16, 290 (1967).

    Article  CAS  Google Scholar 

  • Frohman, L. A.: Clinical neuropharmacology of hypothalamic releasing factors. New Engl. J. Med. 286, 1391 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Geschwind, I.I.: Mechanism of action of releasing factors. In: Frontiers in neuroendocrinology, ed. Ganong, W.F., Martini, L. New York: Oxford University Press 1969.

    Google Scholar 

  • Gillessen, D., Felix, A.M., Lergier, W., Studer, R.O.: Synthese des Thyrotropin releasing-Hormons (TRH) (Schaf) und verwandter Peptide. Helv. chim. Acta 53, 63 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Hall, R., Amos, J., Garry, R., Buxton, R.L.: Thyroidstimulating hormone response to synthetic thyrotrophin releasing hormone in men. Brit. med. J. 1970/II, 274.

    Article  Google Scholar 

  • Hammerschlag, R., Leeman, S.E.: Induction of salivation by a bovine hypothalamic factor. Fed. Proc. 25, 192 (1966).

    Google Scholar 

  • Harris, G.W.: Humors and hormones. J. Endocr. 53, II (1972).

    Google Scholar 

  • Hess, W.R.: Die funktionelle Organisation des vegetativen Nervensystems. Basel: Benno Schwabe 1948.

    Google Scholar 

  • Mccann, S.M., Porter, J.C.: Hypothalamic pituitary stimulating and inhibiting hormones. Physiol. Rev. 49, 240 (1969).

    PubMed  CAS  Google Scholar 

  • Meites, J.: Hypophysiotropic hormones of the hypothalamus: Assay and chemistry. Baltimore: Williams & Wilkins Co. 1970.

    Google Scholar 

  • Nair, R. M. G., Barrett, J.F., Bowers, C. Y., Schally, A.V.: Structure of porcine thyrotropin releasing hormone. Biochemistry 9, 1103 (1970).

    Article  PubMed  CAS  Google Scholar 

  • — Kastin, A.J., Schally, A. V.: Isolation and structure of hypothalamic MSH release-inhibiting hormone. Biochem. biophys. Res. Commun. 43, 1376 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Nauta, W. J. H.: Central nervous organization and the endocrine motor system in Nalbandov, A. V.: Advances in Neuroendocrinology. Urbana: Univ. Illinois Press 1963.

    Google Scholar 

  • Raisman, G.: Neural connections of the hypothalamus. Brit. med. Bull. 22, 197 (1966).

    PubMed  CAS  Google Scholar 

  • Reichlin, S.: Functions of the median-eminence gland. New Engl. J. Med. 275, 600 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Rothballer, A. B.: Some endocrine manifestations of central nervous system disease. An approach to clinical neuroendocrinology. Bull. N.Y. Acad. Med. 4, 257 (1966).

    Google Scholar 

  • Ruf, K., Steiner, F. A.: Steroid-sensitive single neurons in rat hypothalamus and midbrain: Identification by microelectrophoresis. Science 156, 667 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Schally, A.V., Arimura, A., Bowers, C.Y., Kastin, A. J., Sawano, S., Redding, T.W.: Hypothalamic neurohormones regulating anterior pituitary function. Recent Progr. Hormone Res. 24, 497 (1968).

    PubMed  CAS  Google Scholar 

  • — Baba, V., Bennett, C.D.: The amino acid sequence of a peptide with growth hormone-releasing activity isolated from porcine hypothalamus. J. biol. Chem. 246, 6647 (1971).

    PubMed  CAS  Google Scholar 

  • Schaltenbrand, G., Bailey, P.: Einführung in die stereotaktischen Operationen mit einem Atlas des menschüchen Gehirns. Stuttgart: Thieme 1959.

    Google Scholar 

  • Scharrer, E.: Principles of neuroendocrine integration. In: Levine, R., Endocrines and the central nervous system. Baltimore: Wilhams & Wilkins 1966.

    Google Scholar 

  • — Scharrer, B.: Hormones produced by neurosecretory cells. Recent Progr. Hormone Res. 10, 183 (1954).

    CAS  Google Scholar 

  • Spatz, H.: Das Hypothalamus-Hypophysen-System in Hinsicht auf die zentrale Steuerung der Sexualfunktionen. Beriin-Göttingen-Heidelberg: Springer 1955.

    Google Scholar 

  • Studer, R., Werner, I.: Thyrotropin-releasing factor (TRF). Schweiz. med. Wschr. 100, 1086 (1970).

    PubMed  CAS  Google Scholar 

  • Szentagothai, J., Flesko, B., Mess, B., Halasz, B.: Hypothalamic control of the anterior pituitary, 3rd ed. Budapest: Publ. House Hung. Acad. Sci. 1968.

    Google Scholar 

  • Vale, W., Burgus, R., Dunn, TH.F., Guillemin, R.: Release of TSH by oral administration of synthetic peptide derivatives with TRF activity. J. din. Endocr. 30, 148 (1970).

    Article  CAS  Google Scholar 

  • Veber, D.F., Bennett, C. D., Milkowski, J. D., Gal, G., Denkewalter, R.G., Hirschmann, R.: Synthesis of a proposed growth hormone releasing factor. Biochem. biophys. Res. Commun. 45, 235 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Yates, F.E., Russell, S.M., Maran, J.W.: Brain-adenohypophysial communication in mammals. Ann. Rev. Physiol. 33, 393 (1971).

    Article  CAS  Google Scholar 

Pathology and Clinics

  • Albright, F., Reifenstein, E. C.: The parathyroid glands and metabolic bone disease. Baltimore: Williams & Wilkins Company 1948.

    Google Scholar 

  • Bauer, H.C.: Endocrine and other clinical manifestations of hypothalamic disease. A survey of 60 cases with autopsies. J. din. Endocr. 14, 13 (1954).

    Article  CAS  Google Scholar 

  • — Endocrine and metabolic conditions related to pathology in the hypothalamus: a review. J. nerv. ment. Dis. 128, 323 (1959).

    PubMed  CAS  Google Scholar 

  • Betghe, H., Irmscher, K., Zimmermann, H.: Das Verhalten der Corticosteroide im Plasma während der Insulinhypoglykämie und unter Lysin-Vasopressin als Funktionsprüfung des Hypothalamus-Hypophysen-Nebennierenrinden-Systems. Acta endocr. (Kbh.) 55, 622 (1967).

    Google Scholar 

  • Bierich, J. R., Braun, W.: Endokrine Störungen bei Zwischenhirnerkrankungen. Verh. dtsch. Ges. inn. Med. 71, 282 (1965).

    PubMed  CAS  Google Scholar 

  • Courvoisier, B., Fasel, J., Vernet, A., Berthoud, E.: Tuberculose atypique avec syndrome hypothalamo-hypophysaire progressif aboutissant à un panhypopituitarisme. Schweiz. med. Wschr. 90, 870 (1960).

    PubMed  CAS  Google Scholar 

  • Eik-Nes, K., Clark, L.D.: Diurnal variation of plasma 17-hydroxycorticosteroids in subjects suffering from severe brain damage. J. din. Endocr. 18, 764 (1958).

    Article  CAS  Google Scholar 

  • Hall, R., Warrick, CH.: Hypersecretion of hypothalamic releasing hormones: A possible explanation of the endocrine manifestations of polyostotic fibrous dysplasia (Albright’s syndrome). Lancet 1972 I, 1313.

    Article  Google Scholar 

  • Hedinger, Chr., Hürzeler, D.: Hypopituitarismus bei Dystopie des Hypophysenhinterlappens. Acta endocr. (Kbh.) 14, 170 (1953).

    CAS  Google Scholar 

  • Hokfelt, B., Luft, R.: The effect of suprasellar tumours on the regulation of adrenocortical function. Acta endocr. (Kbh.) 32, 177 (1959).

    CAS  Google Scholar 

  • Kahana, L., Kahana, S., Mcpherson, H.T.: Endocrine manifestations of intracranial extrasellar lesions. In: Bajusz, Clinical neuroendocrinology. Basel-New York: Karger 1967.

    Google Scholar 

  • — Lebovitz, H., Lusk, W., Mcpherson, H.T., Davidson, E.T., Oppenheimer, J. H., Engel, F.L., Woodhall, B., Odom, G.: Endocrine manifestations of intracranial extrasellar lesions. J. din. Endocr. 22, 304 (1962).

    Article  Google Scholar 

  • Krayenbühl, H., Zollinger, H. U.: Malignes metastasierendes Pinealocytom mit dem khnischen Bild der Dystrophia adiposo-genitalis. Schweiz. Arch. Neurol. 51, 77(1943).

    Google Scholar 

  • Krieger, D.T., Krieger, H. P.: Effects of organic brain lesions on adrenal cortical activity. In: Levine, R., Endocrines and the central nervous system. Baltimore: Williams & Wilkins 1966.

    Google Scholar 

  • Landon, J., Greenwood, F. C., Stamp, T. C. G., Wynn, V.: The plasma sugar, free fatty acid, Cortisol and growth hormone response to insulin and the comparison of this procedure with other tests of pituitary and adrenal function. II. In Patients with hypothalamic or pituitary dysfunction or anorexia nervosa. J. din. Invest. 45, 437 (1966).

    CAS  Google Scholar 

  • Lange-Cosack, H.: Zur Frage der hypothalamischen Pubertas praecox. In: Zentrale Steuerung der Sexualfunktionen. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  • Linquette, M., Laine, E., Fossati, P., Lefebvre, J.: Pinéalome ectopique avec insuffisance hypophysaire antérieure, adipsie et hypernatrémie neurogene. Ann. Endocr. (Paris) 28, 39 (1967).

    CAS  Google Scholar 

  • Lipsett, M. B., Dreifuss, F. E., Thomas, L. B.: Hypothalamic syndrome following varicella. Amer. J. Med. 32, 471 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Martin, L.G., Martul, P., Connor, T. B., Wiswell, J.G.: Hypothalamic origin of idopathic hypopituitarism. Metabolism 21, 143 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Morgan, T., Coupland, W. G., Vanderfield, G. K., Church, D.: Hypothalamic-pituitary sarcoidosis. Aust. Ann. Med. 14, 250 (1965).

    PubMed  CAS  Google Scholar 

  • Nowakowski, H.: Ãœber die endokrine Symptomatik bei Erkrankungen des Hypothalamus. Verh. dtsch. Ges. inn. Med. 61, 49 (1955).

    Google Scholar 

  • Oppenheimer, J. H., Fisher, L. V., Jailer, J. W.: Disturbance of the pituitary-adrenal interrelationship in diseases of the central nervous system. J. din. Endocr. 21, 1023 (1961).

    Article  CAS  Google Scholar 

  • Orthner, H.: Pathologische Anatomie und Physiologie der hypophysär-hypothalamischen Krankheiten. In: Handbuch der speziellen pathologischen Anatomie und Histologie, O. Lubarsch, F. Henke, R. Rössle, Bd. XIII, Nervensystem, Teil 5, S. 543–939. Berlin-Göttingen-Heidelberg: Springer 1955.

    Google Scholar 

  • Rothballer, A. B.: Some endocrine manifestations of central nervous system disease. Bull. N.Y. Acad. Med. 42, 257 (1966).

    PubMed  CAS  Google Scholar 

  • Wolff, S. M., Adler, R. C., Buskirk, E. R., Thompson, R. H.: A syndrome of periodic hypothalamic discharge. Amer. J. Med. 36, 956 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Wyk, J. J. Van, Dugger, G. S., Newsome, J. F., Thomas, P. Z.: The effect of pituitary stalk section on the adrenal function of women with cancer of the breast. J. din. Endocr. 20, 157 (1960).

    Article  Google Scholar 

Added in Proofs

  • Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J., Guillemin, R.: Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 179, 77 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Gual, C., Rosemberg, E. (eds.): Hypothalamic hypophysiotropic hormones; physiological and clinical studies. Excerpta med. (Amst.) (1973).

    Google Scholar 

  • Schally, A. V., Arimura, A., Kastin, A. J.: Hypothalamic regulatory hormones. Science 179, 341 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Wilber, J.F.: Thyrotropin releasing hormone: secretion and actions. Ann. Rev. Med. 24, 353 (1973).

    Article  PubMed  CAS  Google Scholar 

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Labhart, A. (1974). The Hypothalamus. In: Clinical Endocrinology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96158-8_2

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  • DOI: https://doi.org/10.1007/978-3-642-96158-8_2

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